DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42685 and Pkd1

DIOPT Version :9

Sequence 1:NP_609717.5 Gene:CG42685 / 34854 FlyBaseID:FBgn0261571 Length:1609 Species:Drosophila melanogaster
Sequence 2:NP_001244281.1 Gene:Pkd1 / 24650 RGDID:3333 Length:4292 Species:Rattus norvegicus


Alignment Length:1991 Identity:338/1991 - (16%)
Similarity:600/1991 - (30%) Gaps:683/1991 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFLYFMTISMSLVLIMENSGTPL---------MSLLDGTFLEAYNRSTESPEGGPTSHPWRSAEA 56
            :|:|.:.:...|.::..:.|...         .::.|||.: :|: .|...:||||     ...:
  Rat  1617 IFIYVLQLIEGLQVVGGDGGCCFPTNYTLQLQAAVRDGTNI-SYS-WTAQQDGGPT-----LISS 1674

  Fly    57 GKISFSERTRFTKMLSRKRHKIIRRTIPEEEERRIERLWDPVLNKSYDF--------SSFEEYNT 113
            || |||    .|.:.:...:..:|.|         ..|.....|::.||        .|......
  Rat  1675 GK-SFS----LTALKASTYYVHLRAT---------NMLGSASANRTIDFVEPVESLILSASPNPA 1725

  Fly   114 TTKTYPTIPSEKFGLEDAARTY---KNISEQKPGENSTHLFNDEDYSWSSVNTEISYGYENQTYE 175
            ...|..|:.:|..|......|:   :.:|.:....::||.|.........|..|...|..|.|.|
  Rat  1726 AVNTSLTLGAELAGGSGVVYTWYLEEGLSRETSMPSTTHTFAAPGLHLVRVTAENQLGSVNATIE 1790

  Fly   176 NGIE---------------------------GSKSQNGNVS------------------------ 189
            ..::                           |..::..||:                        
  Rat  1791 VAVQAPVGGLSIRTSEPDSIFVAAGSTVPFWGQLAEGTNVTWCWTLPGGSKYSQYIDVRFPAAGH 1855

  Fly   190 FSL------------ADFPLVDEYPIYN----QSSTCI-------------NNSSTEYQNQT--- 222
            |||            |.:.|..|.||.|    .||..:             ..|:..::.|.   
  Rat  1856 FSLWLNASNAVSWVSAVYNLTVEEPIMNLVLWASSKVVAPGQPVHFQILLAAGSAVTFRLQVGGS 1920

  Fly   223 ----------------VNDYNFAVP---------------------------CLAPNVNGRTSSV 244
                            |.|:..:|.                           |..|.:  .|.:.
  Rat  1921 IPEVLPSLHFSHSFFRVGDHMVSVQAENHVSRAQAQVRILVLEAIVGLQVPNCCEPGM--ATGTE 1983

  Fly   245 KNQQLLGQKGPLKVYL-FMNRNPVYGEEYSVF-----TTMP--------------SLGKKNFAVN 289
            ||.....|:|....|. :.:...|.|:...:.     |..|              .||    .||
  Rat  1984 KNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGILEIHVRAFNELG----GVN 2044

  Fly   290 LTVDTNDYLIDEIHSDWKYTKNLRKLMRKWGIRSKRIVYNRCYFHRCTARF------------YN 342
            ||      |:.|:....:|.               .:...||:.:| :|||            |:
  Rat  2045 LT------LVVEVQDIIQYV---------------TLQSGRCFTNR-SARFEAATSPSPRRVTYH 2087

  Fly   343 ----------------TKHKYIVAKVSSLNDRRKLLAHVVRFKIKVRKPPNVSCLPA-----LEL 386
                            |.|.|:               |...::::|.....||...|     :::
  Rat  2088 WDFGDGTPVQETEESWTDHYYL---------------HPGDYRVEVNATNLVSFFVAQATVTVQV 2137

  Fly   387 EFCKNPEKPVYF--------SPMGHLEFFASISDACS-TVEYDKITWQLCDITENKIIARLKNAT 442
            ..|:.||..|..        |...:||....:.:..| ..||   .|::                
  Rat  2138 LACREPEVEVALPLQVLMRRSQRNYLEAHVDLRNCVSYQTEY---RWEV---------------- 2183

  Fly   443 GLVVKLLPYKVHILNEPDRRKVFLLRGKAVINGVTTVAR--------CY---MKYKPPPIE---- 492
                    |:......|.|....:|.|..|......|.|        |:   :.:...|:.    
  Rat  2184 --------YRTTSCQRPGRMTQMVLPGVDVSRPQLVVPRLALPVGHYCFVFVVSFGDTPLARSIQ 2240

  Fly   493 -----------PLIKGNERRLVDVRKPIIIDGSSSKDRLKIRESIKSK-QFLWTCISLDDPFNNY 545
                       |:|:|...|:....:.:::|||.|.|. .:.:..::. .|.|.|::........
  Rat  2241 ANVTVAAERLVPIIEGGSYRVWSDTQDLVLDGSKSYDP-NLEDGDQTPLNFHWACVASTQSETGG 2304

  Fly   546 CKKYMSK--SPTLRLPPYALKENAVYDFSLTVISRFDPRNRMTTTQTI---KGVAKTTFTPQILC 605
            |......  |..:.:|...|:....|.|:|.|...  .|....|.||:   .|.........:.|
  Rat  2305 CVLNFGPRGSSVVTIPLERLEAGVEYTFNLIVWKA--GRKEEATNQTVLIRSGRVPIVSLECVSC 2367

  Fly   606 RRNCALGVYAPLDS--IHLISKCDDCPGTVKRYEW--------WLLDTESQPTLESSHKYLI--- 657
            :   |..||....|  ::|...|.:|....|:..|        .|:..|:..:..|:..:|:   
  Rat  2368 K---AQAVYEVSRSSYVYLEGHCHNCSSGSKQGRWAARTFSNKTLMLNENTTSTGSTGMHLVVRP 2429

  Fly   658 --LHTLEPLVQIRLRVWVKGQGWADAFYTLRRNNGPQHGSCTIYPFLGVEGF-TMFEIDCPGF-- 717
              ||..|..:.....:...|:....|...|..|..|..|||.::|...|.|. |....:|.|:  
  Rat  2430 GALHDGEGYIFTLTVLGHSGEEEGCASIRLLPNRPPLGGSCRLFPLESVRGLTTKVHFECTGWRD 2494

  Fly   718 -ESPFPPITY---------RYMVSYGVVASNVPYSRIVLTLPAAETIMISICDAIDMCVEKRVEV 772
             |....|:.|         .|...:.:...::.....||. |..:.:.:.   ::.:.||.::..
  Rat  2495 AEDGGAPLVYALRLKRCHQNYCEDFCIYKGSLSTYGAVLP-PGFQPLFVV---SLTVVVEDQLGA 2555

  Fly   773 KVLSIDKSMLTGQKE---------------VMNYVPNFFKRGHWNRAYIMGIAAITFIETSIDGD 822
            .|:::::|:.....|               ..:.:|...::..........:|.||.:.......
  Rat  2556 SVVALNRSLTIVLPEPSGNPADLIPWLHSLTASVLPGLLRQADPQHVIEYSLALITVLNEYEQAP 2620

  Fly   823 EFYS------------------YLTGLVASTGSQMEQITTLSSHMLIRLHPVDFRGATVMAEMFS 869
            :..|                  .|..|..:|...::|||...:..::....:..|  :.:.:|..
  Rat  2621 DMVSEPNLEQQLRAQMRKNITETLISLRVNTVDDIQQITAALAQCMVSSRELMCR--SCLKKMLQ 2683

  Fly   870 HLGDSFSAIVQEHEWLHREGYYSLTAMHMFFMSILGKKTESHSNAMCSLHNPACMNLQIIDLEKP 934
            .| :....|:|...   .||..:.|.:....::|.|.                .::|..:|::.|
  Rat  2684 KL-EGMMRILQAET---TEGTLTPTTIADSILNITGD----------------LIHLASLDMQGP 2728

  Fly   935 FVIKF---DPLILVRINSWLMSTWFLYRCIYFLGVIATQRHHPYDDALTIHKSGIAYQINVTEVT 996
            ..::.   .|.::|...::.:|:..:  ||.....:..      ::.||                
  Rat  2729 QPLELGAEPPSLMVASKAYNLSSALM--CILMRSRVLN------EEPLT---------------- 2769

  Fly   997 ENTKDIQVKTIDHIHVIKLSTKLLYELQRRLNHSSILLQIISQQNFHNIYW--WYPDPFPSKTSV 1059
                              |:.:.:..|.:|.:..|:|           .|.  |.|.        
  Rat  2770 ------------------LAGEEIVALGKRADPLSLL-----------CYGKAWGPS-------- 2797

  Fly  1060 LIVHAYSPVQFFRSAKEFQLTNPLVYKTNITHFNDASFNQYMTNNSI-----QNSTEVHIYSVML 1119
              .|...|..|..:..:......|:...:...|.....:.|..:..:     |..|...|....|
  Rat  2798 --CHFSIPEAFSGALSDLSDVVQLILLVDSNPFPFGYISNYTVSTKVASMAFQTQTGTQIPIEQL 2860

  Fly  1120 NHKAMLAVRIVNCSELMYIKMRLHRWPTLGQIRQHA----------------CRITPDMQGKRIW 1168
            ..:..:.|::.|.|:............|:.|.|...                .|||..:...|..
  Rat  2861 AAERAITVKVPNNSDQAAQSSHSPVGSTIVQPRASVSAVVTADNSNPQAGLHLRITYTVLNARYL 2925

  Fly  1169 IANSCERSPAYVAIH-----KPGEIRYKTEDKDQLSARGRKKGNRTHDGSETPEVRQKADFIDYD 1228
               |.||.| |:|::     :|.|  |......::|.                ||.:.||...|.
  Rat  2926 ---SEEREP-YLAVYLHSVSQPNE--YNCSASRRISL----------------EVLEGADHRPYT 2968

  Fly  1229 ----------------------NEDIVEEVLPLNYSILLEIY--QCNIWKNRSLDPGWSEDHCTT 1269
                                  :...:|..:.| |:.|.:.:  :..:|:...:.|         
  Rat  2969 FFIAPGTGTLGRSYYLNLTSHFHWSALEVSVGL-YTSLCQYFSEEAMMWRTEGIVP--------- 3023

  Fly  1270 SFEHSRGSSVQCTCHTLGALSSRIF-PISSQLFVEHIPVPIFTFNMILMIFFALLFLLLVFKFLL 1333
             .|.:..|...|....|.|..:.:| |.|...|:  .|.|..:.|.|:::...:..:..|     
  Rat  3024 -LEETSPSQAVCLTRHLTAFGASLFVPPSHVQFI--FPEPSVSINYIVLLTCVICLVTYV----- 3080

  Fly  1334 HLNIISAYLKNPEFRLQCDASVGKSDQSFVSGSEIL------------LVIVTGGQEFAGTTSNV 1386
               |::..|:             |.||..||...::            :::.||....:|||::|
  Rat  3081 ---IMAMILR-------------KLDQLDVSRVRVIPFCGKGGRFKYEILVKTGWSRGSGTTAHV 3129

  Fly  1387 KFYL-----KSPHRQQTSYQITQDPGHPKLLRNS--TIKIMVPR--GHIYIPTRLALRLVPNGRY 1442
            ...|     :|.||..        .|.....|||  ..:|..|:  |.::   ::.:.....|..
  Rat  3130 GIMLYGEDNRSGHRHL--------DGDRAFHRNSLDIFQIATPQSLGSVW---KIRVWHDNKGLS 3183

  Fly  1443 PSWYCRSITVVDLKLKVQQLFLVESWI------EGG------------SHIQFMR---------- 1479
            |:|:.:.|.|.||:......|||..|:      .||            :..||.|          
  Rat  3184 PAWFLQHIIVRDLQSARSTFFLVNDWLSVETEANGGLVEKEVLAANEAALWQFQRLLVAELQRGF 3248

  Fly  1480 -SKYFTYGNYSRYPKYTWCKRFRSRAEQ---------LYFS----WYLINAITGPSQSKVGGIIM 1530
             .|:.....:.|.|:    .|| :|.::         |:.:    ||.:...|..|...|..::.
  Rat  3249 FDKHIWLSIWDRPPR----SRF-TRVQRVTCCVLLLCLFLAANAVWYGVVGDTTYSMGPVSSLMS 3308

  Fly  1531 NQFERTCVWICKTAIT----LAFVTLY-FGKHTVSSIQEET 1566
            ...:...:.:..:.:.    ||.:.|: ..:..||..|..|
  Rat  3309 PSVDTVAIGLVSSVVVYPVYLAVLFLFRMSRSKVSGDQNPT 3349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42685NP_609717.5 REJ 411..753 CDD:307914 77/402 (19%)
PLAT 1367..1480 CDD:238061 33/162 (20%)
Pkd1NP_001244281.1 LRRNT 32..71 CDD:214470
LRR_8 61..127 CDD:290566
leucine-rich repeat 70..92 CDD:275378
LRR_4 72..108 CDD:289563
leucine-rich repeat 93..116 CDD:275378
PCC 97..2722 CDD:188093 207/1227 (17%)
leucine-rich repeat 117..129 CDD:275378
LRRCT 125..177 CDD:214507
WSC 177..271 CDD:214616
PKD 277..344 CDD:279180
CLECT 406..530 CDD:214480
PKD 927..1007 CDD:214510
PKD 1017..1115 CDD:214510
PKD 1124..1195 CDD:279180
PKD 1214..1278 CDD:279180
PKD 1289..1370 CDD:214510
PKD 1378..1449 CDD:279180
PKD 1471..1538 CDD:214510
PKD 1546..1615 CDD:279180
PKD 1635..1703 CDD:279180 19/88 (22%)
PKD 1718..1787 CDD:279180 13/68 (19%)
PKD 1807..1871 CDD:279180 6/63 (10%)
PKD 1886..1955 CDD:279180 7/68 (10%)
PKD 1974..2045 CDD:279180 14/76 (18%)
PKD 2062..2129 CDD:279180 14/82 (17%)
GPS 3002..3051 CDD:197639 11/58 (19%)
PLAT_polycystin 3109..3228 CDD:238850 30/129 (23%)
PKD_channel 3700..4102 CDD:285288
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I10909
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1276906at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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