Protein Alignment CG42685 and Pkd1l3

DIOPT Version :10

• Sequence 1: NP_609717.5
• Gene: CG42685 / 34854
• FlyBaseID: FBgn0261571
• Length: 1609
• Species: Drosophila melanogaster
• Sequence 2: XP_017168310.1
• Gene: Pkd1l3 / 244646
• MGIID: 2664670
• Length: 2206
• Species: Mus musculus
• Alignment Length: 912
• Identity: 181/912 - (19%)
• Similarity: 300/912 - (32%)
• Gaps: 236/912 - (25%)

  Fly   809 IAAITFIETSIDGDEFYSYLTGLVASTGSQMEQITTLSSHMLIRLHP-VDFRGATVMAEMFSHLG 872
            |..:|..|::|......:.:|       |:.::.:.|.   :|..|| :.|:.:|....:....|
Mouse   608 ITEVTRPESTIPAGRSLANIT-------SKAQEDSPLG---VISTHPQMSFQSSTSQQALDETAG 662

  Fly   873 DSFSAI--VQEHEWLHREGYYSLTAMHMFFMSILGKKTE----SHSNAMCSLHNPACMNLQIIDL 931
            :....|  .|.|....:.            .:||.:..:    |.::|..|:.|      .:|||
Mouse   663 ERVPTIPDFQAHSEFQKA------------CAILQRLRDFLPTSPTSAQVSVAN------LLIDL 709

  Fly   932 -EKPFVIKFDPLILVRINSWLMSTWFLYRCIYFLGVIAT------------QRHHPYD---DALT 980
             |:..|:.|.     :.|||...|..:......||.:.|            ...||.|   :|..
Mouse   710 SEQLLVLPFQ-----KNNSWSSQTPAVSCPFQPLGRLTTTEKSSHQMAQQDMEQHPMDGAHNAFG 769

  Fly   981 IHKSGIAYQINVT-----EVTENTKDIQVKTIDHIH----------------------------- 1011
            |...|...|.::.     || |:..:..:..:..||
Mouse   770 ISAGGSEIQSDIQLRSEFEV-EDMLETSLMALGEIHRAFCQQSLCPQSAVTLASPSATLMLSSQN 833

  Fly  1012 --VIKLSTKLLYE-------------LQRRLN-HSSILLQIISQQNFHNIYWWYPDPFPSKTSVL 1060
              .:.|||..|.|             |:..|| |..:.||:.....         :||.:.....
Mouse   834 VSTLPLSTYTLGEPAPLTLGFPSAEALKELLNKHPGVNLQVTGLAF---------NPFKTLDDKN 889

  Fly  1061 IVHAYSPVQFFRSAKEFQLTNPLVYKTNITHFNDASFNQYMTNNSIQNSTEVHIYSVMLNHKAML 1125
            ||.:...|| ..||.:....:.|:....|..:.:||.....|  |:..||: | :::.:|..::.
Mouse   890 IVGSIGNVQ-LSSAYQSIRVHDLIEDIEIMLWRNASMETQPT--SLNTSTD-H-FTISVNITSLE 949

  Fly  1126 AVRIVNCSELMYIKMRLHRWPTLG---QIRQHACRITPDMQGKRIWIANSCERSPAYVAIHKPGE 1187
            ...||.......:.|.||    ||   |:......:...:...::|     ::...|..:..|..
Mouse   950 KTLIVTIEPESPLLMTLH----LGFQDQLAHTHFYLNISLPRDQVW-----QKDEEYTWVLTPEN 1005

  Fly  1188 IRYKTEDKDQLSARGRKKGNRTHDGSETPEVRQKADFIDYDNEDIVEEVLPLNYSILLEIYQCNI 1252
            :.|.|.....::...:......|                          .|:..|::..:.||..
Mouse  1006 LWYGTGTYYIMAVENKSTEAAQH--------------------------TPVLVSVVTAVTQCYF 1044

  Fly  1253 WK--NRSLDPGWSEDHCTTSFEHSRGSSVQCTCHTLGALSSRIFPISSQLFVEHIPVPIFTFNMI 1315
            |.  ||:    |..|.|... ..|.....||.|..|...||..|.:...:.||:      |..::
Mouse  1045 WDRYNRT----WKSDGCQVG-PKSTILKTQCLCDHLTFFSSDFFIVPRTVDVEN------TIKLL 1098

  Fly  1316 LMIF-----FALLFLLLVFKFLLHLNIISAYLKNPEFRLQCDASVGKSDQSFVSGSEILLVIVTG 1375
            |.:.     .:||..||.|..||   .:.|..|:.|...:...:| .:|....|.|..|:.:.||
Mouse  1099 LHVTNNPVGVSLLSSLLGFYILL---AMWASRKDREDMQKVKVTV-LADNDPSSASHYLIQVYTG 1159

  Fly  1376 GQEFAGTTSNVKFYLKSPHRQQTSYQITQDPGHPKLLRNSTIKIMVPRGHIYIPTRLALRL--VP 1438
            .:..|.||:.|...|.........:.:. ||......|.:....::..|. ::.....|||  ..
Mouse  1160 YRRRAATTAKVVITLYGSEGHSEPHHLC-DPEKTVFERGALDVFLLSTGS-WLGDLHGLRLWHDN 1222

  Fly  1439 NGRYPSWYCRSITVVDLKLKVQQLFLVESWIEGGSHIQFMRSKYFTYGNYSRYPKYTWCKRFRSR 1503
            :|..||||...:.|.|:..:.:..|....|:.            ...||..|...:|...|....
Mouse  1223 SGDSPSWYVSQVIVSDMTTRKKWHFQCNCWLA------------VDLGNCERDRVFTPASRSELS 1275

  Fly  1504 AEQLYFSWYLINAIT-----------GPSQSKVGGIIMNQFERTCVWICKTAITLA--FVTLYFG 1555
            :.:..||..::...|           .|         .|||.|.....|..|:.|.  .:.:.|.
Mouse  1276 SFRHLFSSTIVEKFTQDYLWLSVATRHP---------WNQFTRVQRLSCCMALLLCDMVINIMFW 1331

  Fly  1556 KHTVSSIQEETRENVDNSLKVHLVVML-----GFFAFLIGLAIHVLFEVI----------ILRWL 1605
            |...::.:..|.:.  ..|.|.|..:|     ....|.|.|....||::|          .::..
Mouse  1332 KMGGTTAKRGTEQL--GPLAVTLSELLVSIQTSIILFPIHLIFGRLFQLIHPPEALPQLPFIQAA 1394

  Fly  1606 WP 1607
            ||
Mouse  1395 WP 1396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..>728	CDD:366875
		PLAT	1367..1480	CDD:238061	24/114 (21%)
Pkd1l3	XP_017168310.1	CLECT	37..142	CDD:153057
		PHA03307	147..>513	CDD:223039
		Herpes_BLLF1	<347..705	CDD:282904	22/124 (18%)
		GPS	1041..1079	CDD:460350	13/42 (31%)
		PLAT_polycystin	1151..1269	CDD:238850	28/131 (21%)
		Polycystin_dom	1729..1914	CDD:466668
		PKD_channel	1919..2139	CDD:462341