Protein Alignment CG42685 and ALOX5

DIOPT Version :10

• Sequence 1: NP_609717.5
• Gene: CG42685 / 34854
• FlyBaseID: FBgn0261571
• Length: 1609
• Species: Drosophila melanogaster
• Sequence 2: NP_000689.1
• Gene: ALOX5 / 240
• HGNCID: 435
• Length: 674
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 112/588 - (19%)
• Similarity: 190/588 - (32%)
• Gaps: 159/588 - (27%)

  Fly    40 ESPEGGPTSHP---WRSAEAGKISFSERTRFTK-----MLSRKRHKIIRRTIPEEEERRIERLWD 96
            ::|.|.....|   |.:.:...:....|.:..:     :|.:.|.|.:...  :::.|.:|  |:
Human    89 KTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETR--QKQYRWME--WN 149

  Fly    97 PVLNKSYDFSSFEEYNTTTKTYPTIPSE-KFGLE---DAARTYKNISEQKPGENSTHLFNDEDYS 157
            |....|.|          .|.:..:|.: :|..|   |....|....|........|:|..   |
Human   150 PGFPLSID----------AKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQS---S 201

  Fly   158 WS----------SVNTEISYGYENQTYENGIEGSKSQNG-NVSFSLADFPLVDEYPIYNQSSTCI 211
            |:          .::..||....|...|:.:.|.:..|| |.........|.::.|:..:...|.
Human   202 WNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECS 266

  Fly   212 --NNSSTEYQNQTVN------------DYNFAVPC----LAPNVNGRTSSVKNQQLLGQKGPLKV 258
              ...|.|.:.|..|            |.|...||    ||..:     .:..:.|..:..|:.:
Human   267 LERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPI-----CLLYKNLANKIVPIAI 326

  Fly   259 YLFMNRNPVYGEEYSVFTTMPSLGKKNFAVNLTVDTNDYLIDEIHSDWKYTKNLRKLMRKWGIRS 323
            .|    |.:.|:|..:|  :||..|                    .||        |:.|..:||
Human   327 QL----NQIPGDENPIF--LPSDAK--------------------YDW--------LLAKIWVRS 357

  Fly   324 KRIVYNRCYFHRCTARFYNTKHKYIVAKVSSLNDRR---------KLLAHVVRFKIKVRKPPNVS 379
            ...     :.|:.......|   ::|::|..:...|         |||...|||.|.:    |..
Human   358 SDF-----HVHQTITHLLRT---HLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAI----NTK 410

  Fly   380 CLPALELEFCKNPEKPVYFSPMGHLEFFASISDACSTVEYDKITWQLCDITENKIIARLKNATGL 444
            ....|..| |...:|.......||::.   :..|...:.|.    .||       ......|.|:
Human   411 AREQLICE-CGLFDKANATGGGGHVQM---VQRAMKDLTYA----SLC-------FPEAIKARGM 460

  Fly   445 VVKL-LPYKVHILNEPDRRKVFLLRGKAVINGVTTVARCYMKYKPPPIEPLIKGNERRLVDVRKP 508
            ..|. :||..:       |...||..:|:......|...|  |:...:..    .:..|.|....
Human   461 ESKEDIPYYFY-------RDDGLLVWEAIRTFTAEVVDIY--YEGDQVVE----EDPELQDFVND 512

  Fly   509 IIIDGSSSKDRLKIRESIKSKQ--------FLWTCISLDDPFN----NYCKKYMSKSPTLRLPPY 561
            :.:.|...:......:|:||::        .::|..:.....|    ::|....:..||:|.||.
Human   513 VYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPP 577

  Fly   562 ALK 564
            ..|
Human   578 TAK 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..>728	CDD:366875	31/167 (19%)
		PLAT	1367..1480	CDD:238061
ALOX5	NP_000689.1	PLAT_LOX	2..115	CDD:238851	4/25 (16%)
		Lipoxygenase	<227..665	CDD:459754	84/433 (19%)