Protein Alignment CG42685 and Pkd1

DIOPT Version :10

• Sequence 1: NP_609717.5
• Gene: CG42685 / 34854
• FlyBaseID: FBgn0261571
• Length: 1609
• Species: Drosophila melanogaster
• Sequence 2: XP_036016298.1
• Gene: Pkd1 / 18763
• MGIID: 97603
• Length: 4316
• Species: Mus musculus
• Alignment Length: 1469
• Identity: 266/1469 - (18%)
• Similarity: 467/1469 - (31%)
• Gaps: 479/1469 - (32%)

  Fly   312 LRKLMRKWGIRSKRIVYNRCYFH----RCTARFYNTKHKYIVAKVSSLNDRRKLLAHVVRFKIKV 372
            |:.|||    ||:|   |....|    .|.:  |.|::::.:.:.:|. .|...:|.:|...:.|
Mouse  2155 LQVLMR----RSQR---NYLEAHVDLRNCVS--YQTEYRWEIYRTASC-QRPGRMAQMVLPGVDV 2209

  Fly   373 RKPPNVSCLPALELEFCKNPEKPVYFSPMGH--LEFFASISDACSTVEYDKITWQLCDITENKII 435
            .:|..|  :|.|.|             |:||  ..|..|..|
Mouse  2210 SRPQLV--VPRLAL-------------PVGHYCFVFVVSFGD----------------------- 2236

  Fly   436 ARLKNATGLVVKLLPYKVHILNEPDRRKVFLLRGKAVINGVTTVARCYMKYKPPPIEPLIKGNER 500
                  |.|                        .:::...||..|.        .:.|:|:|...
Mouse  2237 ------TPL------------------------ARSIQANVTVAAE--------RLVPIIEGGSY 2263

  Fly   501 RLVDVRKPIIIDGSSSKDRLKIRESIKSK-QFLWTCISLDDPFNNYCKKYMSK--SPTLRLPPYA 562
            |:....:.:::|||.|.|. .:.:..::. .|.|.|::........|......  |..:.:|...
Mouse  2264 RVWSDTQDLVLDGSKSYDP-NLEDGDQTPLNFHWACVASTQSETGGCVLNFGPRGSSVVTIPLER 2327

  Fly   563 LKENAVYDFSLTVISRFDPRNRMTTTQTI---KGVAKTTFTPQILCRRNCALGVYAPLDS--IHL 622
            |:....|.|:|.|...  .|....|.||:   .|.........:.|:   |..||....|  ::|
Mouse  2328 LEAGVEYTFNLIVWKA--GRKEEATNQTVLIRSGRVPIVSLECVSCK---AQAVYEVSRSSYVYL 2387

  Fly   623 ISKCDDCPGTVKRYEWWLLDTESQPTLESSHKYLILHTLEPLVQIRLRVWVKGQGW--------- 678
            ...|.:|....|: ..|...|.|..||..:.......:....:.:|......|:|:
Mouse  2388 EGHCHNCSRGYKQ-GCWAARTFSNKTLVLNETTTSTGSTGMNLVVRPGALRDGEGYIFTLTVLGH 2451

  Fly   679 -----ADAFYTLRRNNGPQHGSCTIYPFLGVEGF-TMFEIDCPGF---ESPFPPITYRYMV---- 730
                 ..|...|..|..|..|||.::|...|.|. |....:|.|:   |....|:.|..::
Mouse  2452 SGEEEGCASIRLSPNRPPLGGSCRLFPLDSVRGLTTKVHFECTGWRDAEDGGAPLVYALLLKRCR 2516

  Fly   731 ---------------SYG--------------------------VVASN--VPYSR---IVLTLP 749
                           :||                          |||.|  :|.||   |||..|
Mouse  2517 QSYCENFCIYKGSLSTYGAVLPPGFQPLFVVSLAVVVQDQLGAAVVALNSLLPLSRSLTIVLPEP 2581

  Fly   750 AAETIMISICDAIDMCVEKRVEVKVLSIDKSMLTGQKEVMNYVPNFFKRGHWNRAYIMGIAAITF 814
            :...     .|.:..         :.|:..|:|          |...|:..........:|.||.
Mouse  2582 SGNP-----ADLVPW---------LHSLTASVL----------PGLLKQADPQHVIEYSLALITV 2622

  Fly   815 I---ETSIDGDE--------------FYSYLTGLVASTGSQMEQITTLSSHMLIRLHPVDFRGAT 862
            :   |.:.|..|              ....|..|..:|...::|||...:..::....:..|  :
Mouse  2623 LNEYEQAPDVSEPNVEQQLRAQMRKNITETLISLRVNTVDDIQQITAALAQCMVSSRELMCR--S 2685

  Fly   863 VMAEMFSHLGDSFSAIVQEHEWLHREGYYSLTAMHMFFMSILGKKTESHSNAMCSLHNPACMNLQ 927
            .:.:|...| :....|:|...   .||..:.|.:....::|.|.                .::|.
Mouse  2686 CLKKMLQKL-EGMMRILQAET---TEGTLTPTTIADSILNITGD----------------LIHLA 2730

  Fly   928 IIDLEKPFVIKF---DPLILV-----RINSWLMSTWFLYRC------------IYFLGVIATQRH 972
            .:|::.|..::.   .|.::|     .::|.||......|.            |..||    :|.
Mouse  2731 SLDMQGPQPLELGVEPPSLMVASKAYNLSSALMRILMRSRVLNEEPLTLAGEEIVALG----KRS 2791

  Fly   973 HP-----YDDALTIHKSGIAYQINVTE----VTENTKDIQVKTI----------DHIHVIKLSTK 1018
            .|     |..||     |.:...::.|    ...|..|: |:.|          .:|....:|||
Mouse  2792 DPLSLLCYGKAL-----GPSCHFSIPEAFSGALSNLSDV-VQLIFLVDSNPFPFGYISNYTVSTK 2850

  Fly  1019 LLYELQRRLNHSSILLQIISQQNFHNIYWWYPDPFPSKTSVLIVHAYSPVQFFRSAKEFQLTNPL 1083
            :.....:....:.|.::.::.:....:      ..|:.:......:::||       ...:..|
Mouse  2851 VASMAFQTQTGTQIPIEQLAAERAITV------KVPNNSDQAAQSSHNPV-------GSTIVQP- 2901

  Fly  1084 VYKTNITHFNDASFNQYMTNNSIQNSTEVHIYSVMLNHKAMLAVRIVNCSELMYIKMRLHRWPTL 1148
              :|:::....|.      |::.|....:.|...:||.      |.::.....|:.:.||   ::
Mouse  2902 --QTSVSAVVTAD------NSNPQAGLHLRITYTVLNE------RYLSAEPEPYLAVYLH---SV 2949

  Fly  1149 GQIRQHAC----RITPDMQGKRIWIANSCERSPAYVAIHKPGEIRYKTEDKDQLSARGRKKGNRT 1209
            .|..::.|    ||:.::      :..:..|  .|.....||.   .|.|:....       |.|
Mouse  2950 SQPNEYNCSASRRISLEV------LEGADHR--LYTFFIAPGT---GTLDRSYYL-------NLT 2996

  Fly  1210 ---HDGSETPEVRQKADFIDYDNEDIVEEVLPLNYSILLEIYQCNIWKNRSLDPGWSEDHCTTSF 1271
               |..:....|........|.:|:::                  :|:...:.|          .
Mouse  2997 SHFHWSALEVSVGLYTSLCQYFSEEMM------------------MWRTEGIVP----------L 3033

  Fly  1272 EHSRGSSVQCTCHTLGALSSRIF-PISSQLFVEHIPVPIFTFNMILMIFFALLFLLLVFKFLLHL 1335
            |.:..|...|....|.|..:.:| |.|...|:  .|.|..:.|.|:::...:..:..|
Mouse  3034 EETSPSQAVCLTRHLTAFGASLFVPPSHVQFI--FPEPSASINYIVLLTCVICLVTYV------- 3089

  Fly  1336 NIISAYLKNPEFRLQCDASVGKSDQSFVSGSEIL------------LVIVTGGQEFAGTTSNVKF 1388
             :::..|:             |.||..||...::            :::.||....:|||::|..
Mouse  3090 -VMAMILR-------------KLDQLDVSRVRVIPFCGKGGRFKYEILVKTGWSRGSGTTAHVGI 3140

  Fly  1389 YL-----KSPHRQQTSYQITQDPGHPKLLRNS--TIKIMVPR--GHIYIPTRLALRLVPNGRYPS 1444
            .|     :|.||..        .|.....|||  ..:|..|.  |.::   ::.:.....|..|:
Mouse  3141 MLYGEDNRSGHRHL--------DGDRAFHRNSLDIFQIATPHSLGSVW---KIRVWHDNKGLSPA 3194

  Fly  1445 WYCRSITVVDLKLKVQQLFLVESWI------EGG------------SHIQFMR-----------S 1480
            |:.:.|.|.||:......|||..|:      .||            :..||.|           .
Mouse  3195 WFLQHIIVRDLQSARSTFFLVNDWLSVETEANGGLVEKEVLAANEAALWQFQRLLVAELQRGFFD 3259

  Fly  1481 KYFTYGNYSRYPKYTWCKRFRSRAEQ---------LYFS----WYLINAITGPSQSKVGGIIMNQ 1532
            |:.....:.|.|:    .|| :|.::         |:.:    ||.:...|..|...|..:|...
Mouse  3260 KHIWLSIWDRPPR----SRF-TRVQRVTCCVLLLCLFLAANAVWYGVVRDTTYSMGPVSSLISPG 3319

  Fly  1533 FERTCVWICKTAIT----LAFVTLY-FGKHTVSSIQEET 1566
            .:...:.:..:.:.    ||.:.|: ..:..||..|..|
Mouse  3320 VDTVAIGLVSSVVVYPVYLAVLFLFRMSRSKVSGDQNPT 3358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..>728	CDD:366875	64/342 (19%)
		PLAT	1367..1480	CDD:238061	33/162 (20%)
Pkd1	XP_036016298.1	LRRNT	32..71	CDD:214470
		LRR_8	61..127	CDD:404697
		leucine-rich repeat	70..92	CDD:275378
		leucine-rich repeat	93..116	CDD:275378
		PCC	97..2731	CDD:188093	133/714 (19%)
		leucine-rich repeat	117..129	CDD:275378
		GPS	3011..3060	CDD:470616	11/76 (14%)
		PLAT_polycystin	3118..3237	CDD:238850	30/129 (23%)
		Polycystin_dom	3726..3904	CDD:466668
		PKD_channel	3905..4126	CDD:462341