DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42685 and lov-1

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	NP_496184.3	Gene:	lov-1 / 174576	WormBaseID:	WBGene00003058	Length:	3284	Species:	Caenorhabditis elegans

Alignment Length:	1470	Identity:	249/1470 - (16%)
Similarity:	473/1470 - (32%)	Gaps:	424/1470 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 AKVSSLNDRRKLLAHVVRFKIKVRKPPNVSCLPALEL-----EFCKNPEKPVYFSPMGHLEFFAS 409
            |..:|||....||             ..:|.|||.:|     ....|..|......|..::...:
Worm  1247 ASNNSLNTSSSLL-------------NQISSLPAADLVEVAQSLLSNTLKIPGVGNMSSVDVLKT 1298

  Fly   410 ISDACSTV------EYDKITWQLCDI------TENKIIARLKNA-TGLVVKLLPYKVHILNEPDR 461
            :.|..:|.      |..|:..:|.::      :.|.:::.|..| .|..|    |.:.:.:...:
Worm  1299 LQDNIATTNSELADEMAKVITKLANVNMTSAQSLNSVLSSLDLALKGSTV----YTLGVSSTKSK 1359

  Fly   462 RKVF-LLRGKAVINGVTTVA-RCYMKYKPPPIEPLIKGNER------------------RLVDVR 506
            ...: ::.|..:.:|.|.|: ||.:......|  .:.|:.|                  ..:.::
Worm  1360 DGTYAVIFGYVIASGYTLVSPRCTLSIYGSTI--YLTGDTRASYKQLDGDTVTADTMLAAAIGIQ 1422

  Fly   507 KPIIIDGSS---SKDRLKIRESIKSKQFLWTCISLDD-PFNNYCKKYMSKSPTLRLPPYALKENA 567
            .....:|.:   .:|::..:.|:.|...:.|...:.| ....|....|          |....|.
Worm  1423 GMFATNGRTVQVEQDKIDDKRSLVSGNIMATMSGVGDVQSGEYSYNDM----------YVTAWNV 1477

  Fly   568 VYDFSLTVISRFDPRN------------------------RMTTTQTI--KGVAKT------TFT 600
            .||.|  .:.....:|                        ::.:||.|  :|:..|      |:|
Worm  1478 TYDNS--TVGSTSQKNTSFSFNIPVSEVQYILLIESGTMIKLHSTQNIVSRGLVVTASYGGVTYT 1540

  Fly   601 PQILCRR-----------NCALGVYAPLDSIHLISKCDDCPGTVKRYEWWLLDTESQPTLESSHK 654
              |.|..           |......|  ||..:::.......|||:.      .:....:|:.:.
Worm  1541 --ITCTNGTGKFVEVDTDNAIFSYNA--DSFTVVASDGSSASTVKKL------IQMPIVIENVNL 1595

  Fly   655 YLILHTLEPLVQIRLRVWVKGQGWADA-FYTLRRNNGPQHGSCTIYPFLGVEGFTMFEIDCPGFE 718
            .|...|..|||            :::| .|::|....||                  :|..|...
Worm  1596 ALFNQTTSPLV------------FSNAGSYSMRMVLSPQ------------------DIGIPAVS 1630

  Fly   719 SPFPPITYRYMVSYGVVASNVPYSRIVLTLPAAETIMISICDAIDMCVEKRVEVKVLS--IDKSM 781
            :      ....||...::....|::..|.....|..::::...:.......::|...|  :|.:.
Worm  1631 A------LSQTVSISTLSPTASYTKDDLQSLIKEQTLVTVSGTLFFSKASSIDVSGYSFFVDSTA 1689

  Fly   782 LTGQKEVMNYVPNFFKRGHWNRAYIMGIAAITFIETSIDGDEFYSYLTGLVASTGSQMEQITTL- 845
            |.....|...|                |::.|:...|:....:...:|....::|||...:|.:
Worm  1690 LYLSNSVTTLV----------------ISSPTYNIVSLALGGYGIQITAGTYTSGSQTHTVTLME 1738

  Fly   846 -SSHMLIRLHPVDFRGATVMAEMFSHLGDSFSAIVQEHEWLHREGYYSLTAMHMFFMSILGKKTE 909
             |....:|:.     |..:       :.:..:..|.::..:..||..|.|.:.:...|::.::::
Worm  1739 FSDTQKMRID-----GGLI-------IRNGTNGYVIQNGQVSTEGDVSGTKIDIVPQSLMNQESQ 1791

  Fly   910 SH---------------------------SNAMCSLHNPACMNLQIIDLEKPF------------ 935
            ..                           ||::.|:.......|:|. |:.|.
Worm  1792 QQIETILSNTQDFLTNNGMTMTDAEINDTSNSLLSIAGSLTSALKIA-LDNPLSSDLAANLKYAT 1855

  Fly   936 --------VIKFDPLILVRINSWLMSTWFLYRCIYFLGVIATQRHHPYDDALTIHKSGIAYQINV 992
                    |:..||..:|.:.......|..|....|...||               ..:|.|:..
Worm  1856 DNYDSLYNVLPSDPDNIVYVEEMTSEEWAAYVTKMFQKNIA---------------KNLANQLAS 1905

  Fly   993 T-EVTENTKDIQVKTIDHIHVIKLSTKLLYELQRRLNHSSILLQIISQQNF----HNIYWWYPDP 1052
            | :..|||  :..:.|       .:..|.|:....::.:.:::.|....|.    .|...| ...
Worm  1906 TLDTLENT--LAARAI-------ATGNLPYDYSNSVDGTGMVIVIDDASNIVGKTQNCEEW-AFK 1960

  Fly  1053 FPSKTSVLIVHAYSPVQFFRSAKEFQLTNPLVYKTNITHFNDASFNQYMTNNSIQNSTEVHIYSV 1117
            .||..|.|.....:.....:.......|||..|..|        |:..:|:.::    |.||
Worm  1961 LPSPASTLNTAEITDKTLIQVGLVCYATNPRTYVDN--------FDMLITSGAL----EAHI--- 2010

  Fly  1118 MLNHKAMLAVRIVNCSELMYIKMRLHRWPTLGQIRQ------------HACRITPDMQGKRIWIA 1170
              ..:..:.:.|...:..:|:..|......:..:.|            ||.|.|......::.|.
Worm  2011 --KDENQIIIPITGTTAPIYVNGRGSEDDAVLTLMQQGDFASYQILDLHAFRTTNWNNSLQVEII 2073

  Fly  1171 NSCE-----RSPAYVAI---HKPGEIRYKTE---DKDQLSARGR--------------------K 1204
            .|.:     ....|:..   ..||.:....|   |.:.|:....                    |
Worm  2074 ASQDYEIPNNDDTYMFSSFQSLPGPLESNHEWIFDLNTLNKTSNYFVTAGNLINNTGLFFIGIGK 2138

  Fly  1205 KGNRTHDGSETPEVRQKADFIDYDNEDIVE----EVLPLNYSILLEIYQC-------NIWKNRSL 1258
            :.:.|:.|:       .:|.::|...|.::    ..:|::|.:......|       :::.:..:
Worm  2139 RNSSTNTGN-------SSDIVNYGQYDSMQWSFARSVPMDYQVAAVSKGCYFYQKTSDVFNSEGM 2196

  Fly  1259 DP----GWSEDHCTTSFEHSRGSSVQCTCHTLGALSSRIFPISSQLFVEHIPVPIFTFNMILMIF 1319
            .|    |....:|:|  :|       .|..::||.:    |.....|..:..|.....|:.:||
Worm  2197 YPSDGQGMQFVNCST--DH-------LTMFSVGAFN----PTIDADFSYNYNVNEIEKNVKVMI- 2247

  Fly  1320 FALLFLLLVFKFLLHLNIISAYLKNPEFRLQCDASVGK----SDQSFVSGSEILLVIVTGGQEFA 1380
             |.:|:|:|:. .|.:|.|....|        |||.|:    .|.....|...::.:.||.:.||
Worm  2248 -AAVFMLVVYG-CLTINAIICQRK--------DASRGRLRFLKDNEPHDGYMYVIAVETGYRMFA 2302

  Fly  1381 GTTSNVKFYLKSPHRQQ--TSYQITQD-----PGHPKLLRNSTIKIMVPRGHI-YIPTRLALRLV 1437
            .|.|.:.|.|......|  .|::..:|     |..........:....|.|.: |:  ||.|...
Worm  2303 TTDSTICFNLSGNEGDQIFRSFRSEEDGNWEFPFSWGTTDRFVMTTAFPLGELEYM--RLWLDDA 2365

  Fly  1438 PNGRYPSWYCRSITVVDLKLKVQQLFLVESWI--EGGSHIQFMRSKYFTYGNYSRYPKYTWCKRF 1500
            ......||||..|.|.||:.:....|...:|:  :.|.            |...|..:..:.:||
Worm  2366 GLDHRESWYCNRIIVKDLQTQDIYYFPFNNWLGTKNGD------------GETERLARVEYKRRF 2418

  Fly  1501 RSRAEQLY-----FSWYLINAITGPSQSKVGGIIMNQFERTCVWICKTAITLAFVTLYFGKHTV- 1559
            ...:..::     .||:.:  .|| ..:::...:..|.....:......:::..:|:....:::
Worm  2419 LDESMSMHMLAQTISWFAM--FTG-GGNRLRDRVSRQDYSVSIIFSLVVVSMISITILKSDNSII 2480

  Fly  1560 ---SSIQEETRENVDNSLKVHLVVMLGFFAFLIGLAIHVL 1596
               .|:.|.|....|.:..|...|::.|..     ::|:|
Worm  2481 SDSKSVSEFTFTIKDIAFGVGFGVLITFLN-----SLHIL 2515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	67/422 (16%)
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	29/122 (24%)
lov-1	NP_496184.3	GPS	2177..2226	CDD:197639	10/61 (16%)
		PLAT_polycystin	2288..2413	CDD:238850	31/138 (22%)
		PKD_channel	2723..3175	CDD:285288
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010