DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42685 and Pkd1l1

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	XP_036013024.1	Gene:	Pkd1l1 / 171395	MGIID:	2156538	Length:	2551	Species:	Mus musculus

Alignment Length:	1060	Identity:	206/1060 - (19%)
Similarity:	350/1060 - (33%)	Gaps:	363/1060 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   645 SQPTL-----------ESSHKYLILHTLEPLVQIR-----------LRVWVKGQ----GWADAFY 683
            ::|||           .:.|.|.....:.|.|.|:           |:..|..:    |.|..:.
Mouse   815 AKPTLMIDWPKALVSQAAFHGYTTSGIMGPAVTIKPFSLSSGKTYVLQASVASKHVLLGKAQLYL 879

  Fly   684 TLRRNNGPQHGSCTIYPFLGVEGFTMFEIDCPGFESPFPPITYRYMVSYGVVASNVPY----SRI 744
            |:  |..||..||.:.|..|:|.:|:|.:.|   .|..|...|.:....|..:|:..|    ::.
Mouse   880 TV--NQAPQDMSCQVRPHHGMEAYTIFSVFC---MSGKPDFHYEFRYRIGNTSSHTLYRGQDTQH 939

  Fly   745 VLTLPAAETIMISICDAIDMCVEKRVEVKVLSIDKSMLTGQKEVMNYVPNFFKRGHWNRAYIMGI 809
            ...|||.:                       |.|...:....|:.:        ||.::.....:
Mouse   940 YFLLPAGD-----------------------SSDNYKVIVSTEITD--------GHGSKVQPCTV 973

  Fly   810 AAITFI-----ETSIDGDEFYSYLTGL--VASTGSQME--QITTLSSHMLIRLHPVDFRGATVMA 865
             |:|.:     ....|.:.:.|.|..|  :...||.||  ...|:.:.:|.||: |:.|. |...
Mouse   974 -AVTVLPRYHGNDCCDKELYNSTLESLSTLRLAGSYMETRNYITMITGILSRLY-VESRN-TSSC 1035

  Fly   866 EMFSHLGDSFSAIVQEHEWLHREGYYSLTAMHMFFMSILGKKTESHSNAMCSLHNPACMNLQIID 930
            ..:|.:.|...:...:..:..:||  .:.::|:....|......|.::|||           |..
Mouse  1036 GQWSQIQDVLISSACKVPYTDQEG--MMDSIHILRDLISFPNKLSLTSAMC-----------IFK 1087

  Fly   931 LEKPFVI--KFDPLILV----RINSWLMSTWFLYRCIYFLGVIATQRHHPYDDALTIHKSGIAYQ 989
            ..|.|:.  :|...:||    |:...|:.:          ||....:    :||    :.|...|
Mouse  1088 YTKMFLAQGQFSRRLLVDKKLRVEFVLLIS----------GVWEAAK----EDA----RDGDYLQ 1134

  Fly   990 INVTEVTENTKDIQVKTIDHIHVIKLSTKLLYELQRRLN---HSSILLQIISQQNFHNIYWWYPD 1051
               .|..:...|:.:..:...|.|.:||..: |.|..|:   .|||       ||...:...:|.
Mouse  1135 ---EEGMKIISDMLLACLSDEHQIHVSTGQM-EFQTLLHRSPQSSI-------QNLGFVQVHFPS 1188

  Fly  1052 PFPSKTS----------------------------------VLIVHAYS-----PVQFFRSAKEF 1077
            ...|..|                                  |:|...||     |:  .|...|.
Mouse  1189 DLASLHSTTQEATQSSCYISQLMFFMKSPYLGGQVPGQVGGVMIPRLYSCESRRPI--LRGQLET 1251

  Fly  1078 QLT--------------NPLVY-----KTNITHFNDASFNQYMTNNSIQNSTEVHIYSVMLNHKA 1123
            .:|              ||.::     :.|:..|...|.|.       |.|.::||.......:.
Mouse  1252 PVTMEFGEEDYLVKHKRNPAMFVLLRDEVNVHRFTGLSENS-------QESLQIHIKFSKPVTRP 1309

  Fly  1124 MLAVRIVNCSELM----YIKMRLHRWPTLGQIRQHACRITPDMQGKRIWIANSCERSPAYVAIHK 1184
            ...:.:|..||..    ::..|::.|               |.|..::::       ||  |..|
Mouse  1310 FPIILLVRFSEKATPSDFLVKRVYFW---------------DEQTVQMYV-------PA--APWK 1350

  Fly  1185 PGEIRYKT---EDKDQLSARGRKKGNRTHDGSETPEVRQKADFIDYDNEDIVEEVLPLNYSILLE 1246
            ...:.|.:   .|.|      ||..|:...|:                         :||::..:
Mouse  1351 GANVGYLSLLDADYD------RKPPNKYLAGA-------------------------VNYTVHFQ 1384

  Fly  1247 IYQCNIWKNRSL-------DPGWSEDHCTTSFEHSRGSSVQCTCHTLGALSSRIFPISSQLFVEH 1304
            ..||..|.....       .||.|.:            .|.|:.|.|..:|.....:::.|.|..
Mouse  1385 WIQCVFWDKTEWRSEGPYPQPGSSPE------------KVNCSYHHLAPVSVLRRKLNATLEVSS 1437

  Fly  1305 I-PVPIFTFNMILMIFFALLFLLLVFKFLLHLNIISAYL-----KNPEFRLQCDASVGKSDQSFV 1363
            | .......|::..||.|  |||:::..|:..   |.|:     |||.|..        .::..:
Mouse  1438 ISEFQSHPHNLLPGIFSA--FLLVLYGILVSK---SRYVDCHEKKNPGFIF--------LEEDTL 1489

  Fly  1364 SGSEILLVIV-TGGQEFAGTTSNVKFYLKSPHRQQTSYQITQDPGHPKLLRNSTIKIMVPRGHIY 1427
            .|.::..|:: ||.:.....||.|...|...:....:.::. .|..|...|||.        |.:
Mouse  1490 PGYQLYAVVIDTGFRSPVRFTSKVFIVLCGENGCSETKELC-CPEKPLFGRNSR--------HTF 1545

  Fly  1428 ---IPTRLA----LRL--VPNGRYPSWYCRSITVVDLKLKVQQLFLVESWI---EGGSHIQFMRS 1480
               ||.:|.    :||  ..:|..|.|:...:.|.:|.......|..:.|:   :.|.|:  :|
Mouse  1546 ILSIPNQLGPLQKIRLWHDSSGSSPCWFISHVMVKELCSGQAWFFSAQCWLAVSKLGGHV--LR- 1607

  Fly  1481 KYFTYGN--------YSRYPKY-----TWCKRF-----RS--RAEQLYFSWYLINAITGPSQSKV 1525
            ::|...:        ||::.:|     .|...:     ||  ..::|..|:.|:
Mouse  1608 EFFCLSHGLGFWKLFYSKFTEYLEDFHIWLSLYSQPPSRSYLHTQRLAVSFCLL----------- 1661

  Fly  1526 GGIIMNQFERTCVWICKTAI 1545
                       ||:.|.||:
Mouse  1662 -----------CVYSCLTAL 1670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	33/137 (24%)
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	27/125 (22%)
Pkd1l1	XP_036013024.1	PCC	<167..622	CDD:188093
		REJ	<835..976	CDD:366875	35/177 (20%)
		GPS	1387..1425	CDD:413374	11/49 (22%)
		PLAT	1493..1611	CDD:412108	28/129 (22%)
		PKD_channel	2023..>2331	CDD:400395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11148
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010