Protein Alignment CG42685 and PKD1L2

DIOPT Version :10

• Sequence 1: NP_609717.5
• Gene: CG42685 / 34854
• FlyBaseID: FBgn0261571
• Length: 1609
• Species: Drosophila melanogaster
• Sequence 2: NP_443124.4
• Gene: PKD1L2 / 114780
• HGNCID: 21715
• Length: 2463
• Species: Homo sapiens
• Alignment Length: 1152
• Identity: 216/1152 - (18%)
• Similarity: 389/1152 - (33%)
• Gaps: 310/1152 - (26%)

  Fly   527 KSKQFLWTCISLDDPFNNYCKKYMSKS-------PTLRLPPYALKENAVYDFSLTVISRFDPRNR 584
            |..:|.|:|.|....:::..::.:.::       |...|||   .::|| ...|.|:...:..||
Human   585 KELRFQWSCGSCWALWSSCVERQLLRTDQRELVVPASCLPP---PDSAV-TLRLAVLRGQELENR 645

  Fly   585 MTTTQTIKGVAKTTFTPQILCRRNCALGVYAPLDSIHLISKCDDCPGTVKRYEWWLLDT---ESQ 646
              ..|.:...|.....|::.|.|||. .|.|..|.:..::..:|.|  |..:.|:|.:|   :::
Human   646 --AEQCLYVSAPWELRPRVSCERNCR-PVNASKDILLRVTMGEDSP--VAMFSWYLDNTPTEQAE 705

  Fly   647 P----------------TLESSHKYLILHT--LE---PLVQIRLRVWVKGQGWADAFYTLRRNNG 690
            |                .|:|:...|:|::  |:   .:::||.....: ..:.:..|.:.....
Human   706 PLLDACRLRGFWPRSLTLLQSNTSTLLLNSSFLQSRGEVIRIRATALTR-HAYGEDTYVISTVPP 769

  Fly   691 PQHGSCTIYPFLGVEGFTMFEIDCPGFESPFPPITYRYMVSYGVVASNVPYSRIVLTLPAAETIM 755
            .:..:|||.|..|.. .|.|.|.| ...:...|:.:.:.:..|......|.       ||..::.
Human   770 REVPACTIAPEEGTV-LTSFAIFC-NASTALGPLEFCFCLESGSCLHCGPE-------PALPSVY 825

  Fly   756 ISICDAIDMCVEKRVEVKVLSIDKSMLTGQKEVMNYVPNFFKRGHWNRAYIMGIAAITFIETSID 820
            :.:.:..:..|   :.|.:.:.:::..|.|.:.|                    |.:...:|.::
Human   826 LPLGEENNDFV---LTVVISATNRAGDTQQTQAM--------------------AKVALGDTCVE 867

  Fly   821 GDEFYSYL-----TGLVASTG-SQMEQITTLSSHMLIRLHPVDFRGAT----VMAEMFSHLGDSF 875
            ...|.:.:     |.|....| .|:.|:....|.||.:.|.....|.:    |..::..|:..|.
Human   868 DVAFQAAVSEKIPTALQGEGGPEQLLQLAKAVSSMLNQEHESQGSGQSLSIDVRQKVREHVLGSL 932

  Fly   876 SAIVQEHEWLHREGYYSLTAMHMFFMSILGKKTESHSNAMCSLHNPACMNLQIIDLEKPFVIKFD 940
            ||:....|.:.|.         .....:|.:.|........|....|.:.||...         :
Human   933 SAVTTGLEDVQRV---------QELAEVLREVTCRSKELTPSAQWEASLALQHAS---------E 979

  Fly   941 PLILVRINS------WLMSTWFLYRCIYFLGVI--ATQRHHPYDDALTIHKSGIAYQINVTEVTE 997
            .|:.|...:      ...:|..|::.:   |.:  |:..:.|.:.| ....|.||..:.:..|.|
Human   980 ALLTVSAKARPEDQRRQAATRDLFQAV---GSVLEASLSNRPEEPA-EASSSQIATVLRLLRVME 1040

  Fly   998 NTKDIQVKTIDHIHVIKLSTKLLYELQRRLNHSSILLQIISQQNFHNIY------W-WY-----P 1050
                       |:....|..||...|...|...||           ::|      | |.     |
Human  1041 -----------HVQTTLLLGKLPGGLPAMLATPSI-----------SVYTNRIQPWSWQGSSLRP 1083

  Fly  1051 DPFPSKTSVLIVHAYSPVQFFRSAKEFQLTNPLVYKTNITHFNDASF------------------ 1097
            |...|.|.:|  .|.|.:......:|     |:..|  |..|..:.|
Human  1084 DAADSATFML--PAASSLSSLEGGQE-----PVDIK--IMSFPKSPFPARSHFDVSGTVGGLRVT 1139

  Fly  1098 ---NQYMTNNSIQNSTEV--------HIYSVMLNHKAMLAVRIVNCSELMYIKMRLHRWP----- 1146
               .|.:...::..:.|:        |....:||..:..|:.:...|....:.::||..|
Human  1140 SPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWRPDIALT 1204

  Fly  1147 -TLGQIRQHACRITPDMQGKRIWIANSCERSPAYVAIHKPGEIRYKTEDKDQLSARGRKKGNRTH 1210
             :|| ...|..:.:.|.|...:.:. :.:..|.::.  .|.::|:               |...:
Human  1205 LSLG-YGYHPNKSSYDAQTHLVPMV-APDELPTWIL--SPQDLRF---------------GEGVY 1250

  Fly  1211 DGSETPEVRQKADFIDYDNEDIVEEVLPLNYSILLEIYQCNIWKNRSLDPGWSEDHCTTSFEHSR 1275
            ..:..||    :|.......|       |...|...:..|..|.  .:...|.:..|...   .|
Human  1251 YLTVVPE----SDLEPAPGRD-------LTVGITTFLSHCVFWD--EVQETWDDSGCQVG---PR 1299

  Fly  1276 GSSVQ--CTCHTLGALSSRIFPIS--------SQLFV--EHIPVPIFTFNMILMIFFALLFLLLV 1328
            .|..|  |.|:.|....|....:|        ::||.  |..||.:.|...:.:::.
Human  1300 TSPYQTHCLCNHLTFFGSTFLVMSNAINIHQTAELFATFEDNPVVVTTVGCLCVVYV-------- 1356

  Fly  1329 FKFLLHLNIISAYLKNPEFRLQCDASVGKSDQSFVSGSEILLVIVTGGQEFAGTTSNVKFYL--- 1390
                  |.:|.|..|:.:.:.:...:|.:.:..|.. ...|:.:.||.:..|.|:|.|...|
Human  1357 ------LVVIWARRKDAQDQAKVKVTVLEDNDPFAQ-YHYLVTVYTGHRRGAATSSKVTVTLYGL 1414

  Fly  1391 ---KSPHRQQTSYQITQDPGHPKLLRNST----IKIMVPRGHIYIPTRLALRL--VPNGRYPSWY 1446
               :.||.       ..||..|...|.:.    :..:.|.|.:     .:|||  ..:|..||||
Human  1415 DGEREPHH-------LADPDTPVFERGAVDAFLLSTLFPLGEL-----RSLRLWHDNSGDRPSWY 1467

  Fly  1447 CRSITVVDLKLKVQQLFLVESWI---------------------EGGSHIQFMRSKYFTYGNYSR 1490
            ...:.|.||.:..:..||..||:                     :..||:.||::.......:..
Human  1468 VSRVLVYDLVMDRKWYFLCNSWLSINVGDCVLDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIW 1532

  Fly  1491 YPKYTWCKR---FRSRAEQLYFSWYLINAITG---------PSQSKV 1525
            |..::.|.|   .|.:.....||..|...:|.         |::.|:
Human  1533 YSIFSRCARSSFTRVQRVSCCFSLLLCTMLTSIMFWGVPKDPAEQKM 1579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..>728	CDD:366875	50/231 (22%)
		PLAT	1367..1480	CDD:238061	35/145 (24%)
PKD1L2	NP_443124.4	CLECT	28..153	CDD:214480
		Gal_Rha_Lectin_PKD1L2	157..253	CDD:438688
		REJ	<581..898	CDD:366875	67/354 (19%)
		GPS	1277..1316	CDD:470616	10/43 (23%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	1279..1326		12/51 (24%)
		PLAT_polycystin	1387..1506	CDD:238850	31/130 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1622..1646
		Polycystin_dom	1984..2180	CDD:466668
		PKD_channel	2182..2404	CDD:462341
		Channel pore-region	2344..2366
		Interaction with GNAS and GNAI1. /evidence=ECO:0000269|PubMed:15203210	2383..2463
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2435..2463