DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42685 and PKDREJ

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	NP_006062.1	Gene:	PKDREJ / 10343	HGNCID:	9015	Length:	2253	Species:	Homo sapiens

Alignment Length:	1415	Identity:	271/1415 - (19%)
Similarity:	468/1415 - (33%)	Gaps:	414/1415 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 PVYFSPMGHLEFFASISDACSTVEYDKITWQLCDITENKIIARLKNATG-------------LVV 446
            ||..|........||:...|.........||:..:.          |.|             |.:
Human   230 PVRLSMQAEATINASVQLDCPAARAIAQYWQVFSVP----------AVGQAPDWTQPLDLPQLEI 284

  Fly   447 KLLPYKVHILNEPDRRKVFLLR-------GKAVINGVTTVARCYMKYKPPPIEPLIKGNERRLVD 504
            :..|..:||.|...:..|::..       |...:..|......|:......::.::.|:.....:
Human   285 RNSPLFIHIPNNSLQWGVYVFNFTVSITTGNPKMPEVKDSDAVYVWIVRSSLQAVMLGDANITAN 349

  Fly   505 VRKPIIIDGSSSKDRLKIRESIKSKQFLWTCISLDDPFNNY------------C-------KKYM 550
            ..:.:|:|||:|.|. .....::..||.|.|.:  || .||            |       |...
Human   350 FTEQLILDGSTSSDP-DADSPLQGLQFFWYCTT--DP-RNYGGDRIILGSKEVCHPEQANLKWPW 410

  Fly   551 SKSPTLRLPPYALKENAVYDFSLTVISRFDPR-----NRMTTTQTIKGVAKTTFTPQILCRRNCA 610
            :..|.|.|.|..||.:.||.|.:.:  |.|.|     .|:...|..|.:|      .|.|..||.
Human   411 ASGPVLTLLPETLKGDHVYFFRMVI--RKDSRTAFSDKRVHVLQGPKAIA------HITCIENCE 467

  Fly   611 LGVYAPLDSIHLISKCDDCPGTVKRYEW---------WLLDTESQPTLESSHKYLIL------HT 660
            .. :...|...|...|.:| .:...|:|         .|.|...:.....:..||.:      |.
Human   468 RN-FIVSDRFSLFLNCTNC-ASRDFYKWSILSSSGGEMLFDWMGETVTGRNGAYLSIKAFAFRHF 530

  Fly   661 LEP--LVQIRLRVWVKGQGWADAF-YTLRRNNGPQHGSCTIYPFLGVEGFTMFEIDCPGFESPFP 722
            ||.  .:.:.|..|   .|....| ::...|:|||.|.|.|.|..|:...|.|.:.|..|.....
Human   531 LEAEFSISLYLACW---SGVTSVFRHSFIINHGPQIGECKINPAKGIALITKFVVQCSNFRDKHV 592

  Fly   723 PITYRYMVS---------------YGVV-----ASNVPYSRIVLTLPAAE---TIMISICDAIDM 764
            |:||:.:||               .|.:     .|.||.|.:.:.:.|::   .|...:.|::..
Human   593 PLTYKIIVSDLHSVGEISSVKENTLGTILYLGPQSTVPPSFLPVGMLASQYGLKIYAQVYDSLGA 657

  Fly   765 CVEKRVEVKVLS-IDKSMLTGQKEVMNYVPNFFKRGHWNRAYIMGIAAITFIETSIDGDEFY--S 826
            ..:..:.....: .||:   ..|.|:|.:.:|            .:...:.:.|.|...:|.  .
Human   658 FSQVTLHATAQAPTDKN---SSKTVLNQLLSF------------TVGPSSLLSTLIQKKDFLPAG 707

  Fly   827 YLTGLVASTGSQME-QITTLSSHMLIRLHPVDFRGATVMAEMFSHLGDSFSAIVQEHEWLHREGY 890
            ||..:|||..:.|: ::......:.:|.|.:|               .||...|.
Human   708 YLLYIVASVLNNMKTELPLRDDRVNLRKHLID---------------QSFLLPVS---------- 747

  Fly   891 YSLTAMHMFFMSILGKKTESHSNAMCSLHNPACMNL--------QIIDLEKPFVIKFDPLILVRI 947
             :|..:....|:|. |.|:..|.........|.|.:        :....:|.|  :.:.:.:|
Human   748 -TLVEIGQVVMTIT-KLTQKPSEFTWDAQKRATMRVWQANQALQEYQQKDKRF--RSEQIEIV-- 806

  Fly   948 NSWLMSTWFLYRCIYFLGVIATQRHHPYDDALTIHKSGIAYQINVTEVTENTKDIQVKTID-HIH 1011
                 ||..|......|.:  |..|....|...:.:| ::..|...:|..| |...::|.: :::
Human   807 -----STGILMSLSNILKM--TSPHQVVKDPFYVIES-LSDTILANKVPGN-KTTSMRTPNFNMY 862

  Fly  1012 VIKLSTKLLYELQRR-----------LNHSSI-------LLQIISQQNFHNIYWWYPDPFPSKTS 1058
            |.|:....:.:|.|.           ||.||:       .:..:.....::::.|..|  ...||
Human   863 VKKVEKWGINQLFRNEKHCRNCFYPTLNVSSVPGLSANGPISTMFCDFTNDLFPWLND--QENTS 925

  Fly  1059 VLIVHAYSPVQFFR------SAKEFQLTNPL--VY--KTNITHFNDASFN--------------- 1098
            |       .|..||      :....::|..:  ||  :.|:|.   |:||
Human   926 V-------EVSGFRMTGVADNGSVLEITPDVAEVYLVRKNLTF---AAFNLTVGPNSEVDGSLKK 980

  Fly  1099 -----QYMTNNSIQNSTEVHIYSVMLNHKAMLAVRIVNCSELMYIKMRLHRWPTLGQIRQHACRI 1158
                 .:..::::.....|||.:.::          |..:.|:|         |..||...|...
Human   981 TTGGFSFQVDSTVLREVLVHIVTEVM----------VLFTVLVY---------TGSQITPTALVA 1026

  Fly  1159 T-------PDMQGKRIWIANSCERSPAYVAIHKPGEIRYKTEDKDQLSARGRKKGNRTHDGSETP 1216
            |       |....:......:|....|.| :..|..:.       ||.|:        |  |.:|
Human  1027 TFLVPHDIPPFASQSALFDPACTVKKARV-VCLPVSLL-------QLIAQ--------H--SHSP 1073

  Fly  1217 E-----VRQKADFIDYDNEDIVEEVLPLNYSILLEIYQCNIWKNRSLDPGWSEDHCTTSFEHSRG 1276
            .     |.|...|:...|:.:|.          :.|:.........:...|.|.:|... |.:..
Human  1074 HCTVSIVLQAPRFVMKLNDKLVR----------ISIFSVQCLDMYGIQSEWREGYCILG-EKTSW 1127

  Fly  1277 SSVQCTC--------------------HTLGALSSRIF---PISSQLFV----EHIPVPIFTFNM 1314
            ..|.|.|                    ||...::..|.   |:..:|.:    ...||.:||...
Human  1128 YEVHCICKNVVRARRQLGTIGLTGIHLHTHYVMAKVIVIPNPVDLRLNIIKSLHQNPVTLFTVLF 1192

  Fly  1315 ILMIFFALLFLLLVFKFLLHLNIISAYLK--------NPEFRLQCDASVGKSDQSFVSGSEILLV 1371
            |::::..|.|      :.|:.:.:..:|:        |..:...|                .|:.
Human  1193 IILLYVGLAF------WALYRDEMDQHLRGHVIVLPDNDPYDNLC----------------YLVT 1235

  Fly  1372 IVTGGQEFAGTTSNVKFYLKSPHRQQTSYQITQDPGHPKLLRNSTIKIMVPR----GHIYIPTRL 1432
            |.||.:..:||.:||...|:........:.::. |....|.|.|....::..    |.|:
Human  1236 IFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSH-PHFTTLYRGSINTFLLTTKSDLGDIH----- 1294

  Fly  1433 ALRLVPN--GRYPSWYCRSITVVDLKLKVQQLFLVESWIEGGS------HI-----QFMRSKYFT 1484
            ::|:..|  ||.||||...|.|.:|..:...||:.:.|:...:      |:     :..|..:|.
Human  1295 SIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLSVDTTLDRTFHVTHPDERLTRKDFFF 1359

  Fly  1485 YGNYSRYPKYTWCKRFRSRAEQLYFSWYLINAITGPSQSKVGGIIMNQFERTCVWICKTAITLAF 1549
            ....|..           |...::||.:             ..::...|.|.....|..|:.|:.
Human  1360 IDVSSNL-----------RKNHMWFSIF-------------ASVVAKTFNRLQRLSCCLAMLLSS 1400

  Fly  1550 V---TLYFGKHTVSSIQEETRENVDNSLKVHLVVMLGFFAFLIGLAIHVL 1596
            :   .::|..:...  |.|:||.     |....:|:|..:.||.:.:.:|
Human  1401 LLCNIMFFNLNRQE--QTESRER-----KYMRSMMIGIESVLITIPVQLL 1443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	92/426 (22%)
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	30/129 (23%)
PKDREJ	NP_006062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..177
		REJ	243..711	CDD:280229	107/509 (21%)
		GPS	1100..1166	CDD:295363	10/66 (15%)
		PLAT_polycystin	1231..1346	CDD:238850	31/136 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1494..1562
		PKD_channel	1748..2178	CDD:285288
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10690
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010