Protein Alignment CG42685 and PKDREJ

DIOPT Version :10

• Sequence 1: NP_609717.5
• Gene: CG42685 / 34854
• FlyBaseID: FBgn0261571
• Length: 1609
• Species: Drosophila melanogaster
• Sequence 2: NP_006062.1
• Gene: PKDREJ / 10343
• HGNCID: 9015
• Length: 2253
• Species: Homo sapiens
• Alignment Length: 1415
• Identity: 271/1415 - (19%)
• Similarity: 468/1415 - (33%)
• Gaps: 414/1415 - (29%)

  Fly   395 PVYFSPMGHLEFFASISDACSTVEYDKITWQLCDITENKIIARLKNATG-------------LVV 446
            ||..|........||:...|.........||:..:.          |.|             |.:
Human   230 PVRLSMQAEATINASVQLDCPAARAIAQYWQVFSVP----------AVGQAPDWTQPLDLPQLEI 284

  Fly   447 KLLPYKVHILNEPDRRKVFLLR-------GKAVINGVTTVARCYMKYKPPPIEPLIKGNERRLVD 504
            :..|..:||.|...:..|::..       |...:..|......|:......::.::.|:.....:
Human   285 RNSPLFIHIPNNSLQWGVYVFNFTVSITTGNPKMPEVKDSDAVYVWIVRSSLQAVMLGDANITAN 349

  Fly   505 VRKPIIIDGSSSKDRLKIRESIKSKQFLWTCISLDDPFNNY------------C-------KKYM 550
            ..:.:|:|||:|.|. .....::..||.|.|.:  || .||            |       |...
Human   350 FTEQLILDGSTSSDP-DADSPLQGLQFFWYCTT--DP-RNYGGDRIILGSKEVCHPEQANLKWPW 410

  Fly   551 SKSPTLRLPPYALKENAVYDFSLTVISRFDPR-----NRMTTTQTIKGVAKTTFTPQILCRRNCA 610
            :..|.|.|.|..||.:.||.|.:.:  |.|.|     .|:...|..|.:|      .|.|..||.
Human   411 ASGPVLTLLPETLKGDHVYFFRMVI--RKDSRTAFSDKRVHVLQGPKAIA------HITCIENCE 467

  Fly   611 LGVYAPLDSIHLISKCDDCPGTVKRYEW---------WLLDTESQPTLESSHKYLIL------HT 660
            .. :...|...|...|.:| .:...|:|         .|.|...:.....:..||.:      |.
Human   468 RN-FIVSDRFSLFLNCTNC-ASRDFYKWSILSSSGGEMLFDWMGETVTGRNGAYLSIKAFAFRHF 530

  Fly   661 LEP--LVQIRLRVWVKGQGWADAF-YTLRRNNGPQHGSCTIYPFLGVEGFTMFEIDCPGFESPFP 722
            ||.  .:.:.|..|   .|....| ::...|:|||.|.|.|.|..|:...|.|.:.|..|.....
Human   531 LEAEFSISLYLACW---SGVTSVFRHSFIINHGPQIGECKINPAKGIALITKFVVQCSNFRDKHV 592

  Fly   723 PITYRYMVS---------------YGVV-----ASNVPYSRIVLTLPAAE---TIMISICDAIDM 764
            |:||:.:||               .|.:     .|.||.|.:.:.:.|::   .|...:.|::..
Human   593 PLTYKIIVSDLHSVGEISSVKENTLGTILYLGPQSTVPPSFLPVGMLASQYGLKIYAQVYDSLGA 657

  Fly   765 CVEKRVEVKVLS-IDKSMLTGQKEVMNYVPNFFKRGHWNRAYIMGIAAITFIETSIDGDEFY--S 826
            ..:..:.....: .||:   ..|.|:|.:.:|            .:...:.:.|.|...:|.  .
Human   658 FSQVTLHATAQAPTDKN---SSKTVLNQLLSF------------TVGPSSLLSTLIQKKDFLPAG 707

  Fly   827 YLTGLVASTGSQME-QITTLSSHMLIRLHPVDFRGATVMAEMFSHLGDSFSAIVQEHEWLHREGY 890
            ||..:|||..:.|: ::......:.:|.|.:|               .||...|.
Human   708 YLLYIVASVLNNMKTELPLRDDRVNLRKHLID---------------QSFLLPVS---------- 747

  Fly   891 YSLTAMHMFFMSILGKKTESHSNAMCSLHNPACMNL--------QIIDLEKPFVIKFDPLILVRI 947
             :|..:....|:|. |.|:..|.........|.|.:        :....:|.|  :.:.:.:|
Human   748 -TLVEIGQVVMTIT-KLTQKPSEFTWDAQKRATMRVWQANQALQEYQQKDKRF--RSEQIEIV-- 806

  Fly   948 NSWLMSTWFLYRCIYFLGVIATQRHHPYDDALTIHKSGIAYQINVTEVTENTKDIQVKTID-HIH 1011
                 ||..|......|.:  |..|....|...:.:| ::..|...:|..| |...::|.: :::
Human   807 -----STGILMSLSNILKM--TSPHQVVKDPFYVIES-LSDTILANKVPGN-KTTSMRTPNFNMY 862

  Fly  1012 VIKLSTKLLYELQRR-----------LNHSSI-------LLQIISQQNFHNIYWWYPDPFPSKTS 1058
            |.|:....:.:|.|.           ||.||:       .:..:.....::::.|..|  ...||
Human   863 VKKVEKWGINQLFRNEKHCRNCFYPTLNVSSVPGLSANGPISTMFCDFTNDLFPWLND--QENTS 925

  Fly  1059 VLIVHAYSPVQFFR------SAKEFQLTNPL--VY--KTNITHFNDASFN--------------- 1098
            |       .|..||      :....::|..:  ||  :.|:|.   |:||
Human   926 V-------EVSGFRMTGVADNGSVLEITPDVAEVYLVRKNLTF---AAFNLTVGPNSEVDGSLKK 980

  Fly  1099 -----QYMTNNSIQNSTEVHIYSVMLNHKAMLAVRIVNCSELMYIKMRLHRWPTLGQIRQHACRI 1158
                 .:..::::.....|||.:.::          |..:.|:|         |..||...|...
Human   981 TTGGFSFQVDSTVLREVLVHIVTEVM----------VLFTVLVY---------TGSQITPTALVA 1026

  Fly  1159 T-------PDMQGKRIWIANSCERSPAYVAIHKPGEIRYKTEDKDQLSARGRKKGNRTHDGSETP 1216
            |       |....:......:|....|.| :..|..:.       ||.|:        |  |.:|
Human  1027 TFLVPHDIPPFASQSALFDPACTVKKARV-VCLPVSLL-------QLIAQ--------H--SHSP 1073

  Fly  1217 E-----VRQKADFIDYDNEDIVEEVLPLNYSILLEIYQCNIWKNRSLDPGWSEDHCTTSFEHSRG 1276
            .     |.|...|:...|:.:|.          :.|:.........:...|.|.:|... |.:..
Human  1074 HCTVSIVLQAPRFVMKLNDKLVR----------ISIFSVQCLDMYGIQSEWREGYCILG-EKTSW 1127

  Fly  1277 SSVQCTC--------------------HTLGALSSRIF---PISSQLFV----EHIPVPIFTFNM 1314
            ..|.|.|                    ||...::..|.   |:..:|.:    ...||.:||...
Human  1128 YEVHCICKNVVRARRQLGTIGLTGIHLHTHYVMAKVIVIPNPVDLRLNIIKSLHQNPVTLFTVLF 1192

  Fly  1315 ILMIFFALLFLLLVFKFLLHLNIISAYLK--------NPEFRLQCDASVGKSDQSFVSGSEILLV 1371
            |::::..|.|      :.|:.:.:..:|:        |..:...|                .|:.
Human  1193 IILLYVGLAF------WALYRDEMDQHLRGHVIVLPDNDPYDNLC----------------YLVT 1235

  Fly  1372 IVTGGQEFAGTTSNVKFYLKSPHRQQTSYQITQDPGHPKLLRNSTIKIMVPR----GHIYIPTRL 1432
            |.||.:..:||.:||...|:........:.::. |....|.|.|....::..    |.|:
Human  1236 IFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSH-PHFTTLYRGSINTFLLTTKSDLGDIH----- 1294

  Fly  1433 ALRLVPN--GRYPSWYCRSITVVDLKLKVQQLFLVESWIEGGS------HI-----QFMRSKYFT 1484
            ::|:..|  ||.||||...|.|.:|..:...||:.:.|:...:      |:     :..|..:|.
Human  1295 SIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLSVDTTLDRTFHVTHPDERLTRKDFFF 1359

  Fly  1485 YGNYSRYPKYTWCKRFRSRAEQLYFSWYLINAITGPSQSKVGGIIMNQFERTCVWICKTAITLAF 1549
            ....|..           |...::||.:             ..::...|.|.....|..|:.|:.
Human  1360 IDVSSNL-----------RKNHMWFSIF-------------ASVVAKTFNRLQRLSCCLAMLLSS 1400

  Fly  1550 V---TLYFGKHTVSSIQEETRENVDNSLKVHLVVMLGFFAFLIGLAIHVL 1596
            :   .::|..:...  |.|:||.     |....:|:|..:.||.:.:.:|
Human  1401 LLCNIMFFNLNRQE--QTESRER-----KYMRSMMIGIESVLITIPVQLL 1443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..>728	CDD:366875	84/378 (22%)
		PLAT	1367..1480	CDD:238061	30/129 (23%)
PKDREJ	NP_006062.1	T2SSN	38..>141	CDD:446022
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..177
		REJ	243..711	CDD:366875	107/509 (21%)
		PLAT_polycystin	1231..1346	CDD:238850	31/136 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1494..1562
		Polycystin_dom	1750..1955	CDD:466668
		PKD_channel	1956..2178	CDD:462341