DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42685 and pkd1l1

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	XP_021325910.1	Gene:	pkd1l1 / 101887130	-ID:	-	Length:	2572	Species:	Danio rerio

Alignment Length:	1899	Identity:	331/1899 - (17%)
Similarity:	603/1899 - (31%)	Gaps:	671/1899 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 GYENQTYEN------GIEGSKSQNG--NVSFSLADF------PLVDEYPIYNQSSTCIN------ 212
            |..|.:.||      ...|:...||  |||..:..:      .::....:|:.:.|.||
Zfish    30 GIPNLSKENISMVFITFTGNSGPNGLQNVSVMINGYFTCYIDAILPAAGLYHLNVTLINSIYSHS 94

  Fly   213 --------NSSTEYQNQTVNDYNFAVPCLAPNVNGRTSSVKNQQLLGQKGPL-----KVYLFMNR 264
                    :|.|||.|..::..:..||..||.   .|.:|..||......|:     .|:::.::
Zfish    95 TNWQIRACSSETEYLNLMLSKKDQDVPFCAPL---PTHTVGKQQDKASVTPIDKYKRAVWIYSDK 156

  Fly   265 ------------------NPVY-----GEEYSVFTTMPSLGKKNFAV----NLTVDTNDYLIDEI 302
                              :|:|     |:...:.|| ..:.||.:.:    |:||..:|. :..|
Zfish   157 QAYATQTDIKFMAVAEGLDPLYFFWRFGDGPEIKTT-SRIFKKRYRLPDKYNVTVRVSDG-VTSI 219

  Fly   303 HSDWKYTKNLRKLMRKWGIRSKRIVYNRCYFHRCTARF------------------------YNT 343
            .|| .|...:::     .::..|::|:.......:.:|                        .:|
Zfish   220 RSD-VYAVVIQR-----SVQPNRLLYSPSVLSNSSVKFTCRMSSGTDVSYVWNFGEGTERNGSST 278

  Fly   344 KH-------KYIVAKV-SSLNDRRKLLAHVVRFKIKVRKPPNVSCLPALELEFCKN--PEK-PVY 397
            :|       :||:..: |:|.....|..|:...:...:.||            .||  |.| .|:
Zfish   279 EHHVFYSTGEYIIEVIMSNLVSSASLTGHIFVVEELCQPPP------------VKNMGPHKIQVW 331

  Fly   398 FSPMGHLEFFASISDACSTVEYDKITWQLCDITENKIIARLKNATGLVVKLLPYKVHILNEPDRR 462
            .|....|.........|:..:.....|.:.|::..|::....:.....:.|..|.:|........
Zfish   332 RSQHVRLAVTFETQIECNVSKGLLYRWTIYDMSGQKLLLPHIDTGRQYIDLPKYLLHYGTYKAIA 396

  Fly   463 KVFLLRGKAVINGVTTVARCYMKYKPPPIEPLIKG------NERRLVDVRKPIIIDGSSSKDRLK 521
            || .:.|..|.:..:.:......:   |:. :|.|      |.|..|:|    .:||..|.|...
Zfish   397 KV-QVSGNVVYSNYSVLVEVEHSH---PVS-IISGATNIFINHRIGVNV----TLDGRKSHDPDY 452

  Fly   522 IRESIKSKQFLWTCISLDDPFNN-----YCKKYMSKSPTLRLPPYALK-ENAVYDFSLTVISRFD 580
            ...::   .:.|:|    .|.|.     :.:..||.:..|..|..||| |..:..|:|||.|
Zfish   453 PNNTL---SYSWSC----RPVNTQKSGCFTRNIMSTAALLTFPALALKPEFDLLKFTLTVYS--- 507

  Fly   581 PRNRMTTTQT-IKGVAKTTFTPQILCRRNC---ALGVYAPLDSIHLISKCDDCPGTVKRYEW--W 639
             .||.::::. |..::|......:.| ::|   ::...||. ::....:..||......|.|  :
Zfish   508 -GNRSSSSEMFITVISKHISNVHMSC-KDCQEHSVNWNAPF-TVSAFCEDSDCNTKNVTYRWKLY 569

  Fly   640 LLDTESQPTL-----------------ESSH------------------------KYLILHTLEP 663
            |::..|:...                 ||.|                        .||:...::.
Zfish   570 LVNASSRAAAEVPFCSTMDLGLPSKMEESLHFSRPAVTPNTPALLTESSIPGSLAPYLLSDHIDL 634

  Fly   664 LVQIRLRVWVKGQGWADAFYTLRR------NNGPQHGSCTIYPFLGVEGFTMFEIDCPGFESPFP 722
            ...:.|          |:..:::.      |:...|.:  ::|.:         :..||....||
Zfish   635 TAPVTL----------DSLTSVKHHDVHSPNSNTNHHA--VFPAV---------MHLPGILPSFP 678

  Fly   723 PIT-----YR-------------------YMVSY----GVVASNVPYSRIVLTLPAAET-IMI-- 756
            ..|     :|                   |..:|    |...|:..|......:..|:. |.:
Zfish   679 GETESSGGHRESLSGSDRVSMTDLISDLLYTDNYESLSGDHISDPEYDYYNFGIEEADPGITVGR 743

  Fly   757 ---SICDAIDMCVEKRVEVKVLSI-DKSMLTGQKEVMNYVPNFFKRGHWNRAY-IMGIAA--ITF 814
               |..|:.|...:..|:..:|.: :|::|...|::::  ||.|:      :| :.|:::  :||
Zfish   744 PTGSYPDSYDNEGDNLVDPNLLVVSEKTLLDLDKQLIH--PNVFE------SYTLSGLSSSDVTF 800

  Fly   815 IETSIDGDEFYSYLTGLVASTGSQMEQITTLSSH-------MLIRLHPVDFRGATVMAEMFSHLG 872
            ....:.....  ||..:.||...::...:.|..|       |..::.|...........:|...|
Zfish   801 KPFMLKPKSL--YLLEVFASCEQRLRGKSQLFFHTQAVPEGMNCQVQPNTGNEIHTHFSIFCSTG 863

  Fly   873 D-------SFSAIVQEHEWLHREG-----YYSLTA---MH----MFFMSILGKKTESHSNAMCSL 918
            .       |:|....:.:.|: ||     |:||.:   .|    |.::.|        .|...|.
Zfish   864 KEDLLYEYSYSVGNTKRKLLY-EGRDFQHYFSLPSGDPNHDYKVMVYIEI--------KNQFGSA 919

  Fly   919 HNPACMNLQII-DLEKPFVIKFDP---LILVRINSW--LMSTWF--------------------- 956
            ..|..:.:.:: ..::....:.:|   |.|..:.:.  ||.|..
Zfish   920 TKPCPVTVTVLPSFQRNSSSQLNPDQELYLYGVGNLTSLMKTGSNGDIINYIFILTKVLNRLSLD 984

  Fly   957 LYRCIYFLGVIATQRHHPYDDALTIHK------SGIAYQI-----------------NVTEVTEN 998
            |...:.||.:..|:.........|.||      .||:|:|                 ||.::.::
Zfish   985 LESSVEFLTLTRTELISAVCQLSTTHKVITAAIKGISYEIIYRLIDLIKIPSQLTFYNVKQIIQH 1049

  Fly   999 TKDIQVKTI--------DHIHVI-----------KLSTKLLYELQRRLNH--SSILLQIISQQNF 1042
            ..  ::.|:        ||::.:           .|.:|..::|..:..|  :.::|:.:...|.
Zfish  1050 VH--KISTVLNGSEPPTDHVNALVSLLSGVLEAPVLFSKPGHQLINKALHTITDLILECMMSSNI 1112

  Fly  1043 --HNIYWWYPDPFPSKTSVLIVHAYSPVQFFRSAKEFQLTNPLVYKTNITHFNDASFNQYMTNNS 1105
              :|:          .|:.:.:.|::..:...:.|.|.||     ..:.|.|.:..|.|:..|:.
Zfish  1113 SQYNL----------STTFMELLAWTDDESHSTVKTFGLT-----AFHFTDFLEMQFQQWRINSQ 1162

  Fly  1106 IQNS--TEVHIYSV--------MLNHKAMLAVRIVNCSELMYIKMR------------------- 1141
            .:..  |.:.:||.        |........:|:.||:....||:|
Zfish  1163 QKPCVITWLTVYSQSPYRSSRDMQFSGETADIRLYNCTTRKEIKVRHLSPPVTLEFQRKEETKHS 1227

  Fly  1142 -------------LHRWPTLGQIRQHACRI------------------------TPDMQGK-RIW 1168
                         :|.:....:..|.|.:|                        |||:..| :|:
Zfish  1228 KQTDFTLERSEVNIHEFNITSETLQRAFQITVHFTRPAERPFPILLLLRMYEQPTPDLYNKQKIY 1292

  Fly  1169 IANSCERSPAYVAIHKPGEIRYKTEDKDQLSARGRKKGNRTHDGSETPEVRQKADFIDYDNEDIV 1233
                          |..|:..:....:..|.|.|           ....:..|||:....:...:
Zfish  1293 --------------HWKGKTAHFFLPQSYLHATG-----------TVYLMLLKADYNKSPSNKYI 1332

  Fly  1234 EEVLPLNYSILLEIYQCNIWKNRSLDPGWSEDHC---------TTSFEHSRG--SSVQCTCHTLG 1287
            ...  :||::.:|..:|..|....   .|..|.|         ...|.:..|  :.....|:.|.
Zfish  1333 TRA--VNYTVRIESVECLSWDGAR---QWKPDGCFPLAAVSPDKIYFRYGIGLCNKYSTYCNHLA 1392

  Fly  1288 ALSSRIFPISSQ------------LFVEHIP--VPIFTFNMILMIFFALLFLLLVF--------- 1329
            :     |.:|.:            .|:...|  :|:    ::.:||.||..::.|.
Zfish  1393 S-----FAVSHESITNNYSSADVSQFIHSKPNYIPV----ILAVIFLALHIMVSVICRKADVSLQ 1448

  Fly  1330 ----KFLLHLNIISAYLKNPEFRLQCDASVGKSDQSFVSGSEIL--LVIVTGGQEFAGTTSNVK- 1387
                .|||..|       ||..|.....::   |..|.|.:.:.  :.||..|.|....|..|.
Zfish  1449 KTTGSFLLPEN-------NPSDRFLYAVTI---DTGFRSRTRMTAKVYIVLHGDEGVSQTREVSS 1503

  Fly  1388 -------------FYLKSPHR--QQTSYQITQDPGHPKLLRNSTIKIMVPRGHIYIPTRLALRLV 1437
                         |.|.||..  |.....:..|.|
Zfish  1504 SDSRLFTNNSRNTFILSSPESLGQVWKVHLWHDNG------------------------------ 1538

  Fly  1438 PNGRYPSWYCRSITVVDLKLKVQQLFLVESWI---EGGSHIQFMRSKYFTYGNYS----RYPKYT 1495
              |..||||...:.|.||.......||.:.|:   ||...::  |:...:.|..:    .|.|.|
Zfish  1539 --GSSPSWYLSHVVVKDLVQGSCWFFLGQCWLAVDEGDGRVE--RNLVASEGGLTFKQLLYLKLT 1599

  Fly  1496 WCKRFRSRAEQL--YFSWYLINAITGPSQSK-------------------VGGIIMNQFERTC-- 1537
                     |.|  :..|:  :..:.||.|.                   |..:::|..|..|
Zfish  1600 ---------EYLEDFHPWF--SVYSRPSSSSHTHTQRLSVCLLLLQGYMCVNTLLINLLEEQCFA 1653

  Fly  1538 -------------VWICKTAITL---AFVTLYFGKHTVSSIQE-ETRENVDNSLKVHLVVMLGFF 1585
                         ..:|.....:   ..|:|.|   .||.::. ...|.|     .|.|....::
Zfish  1654 ETGLIDVPAVSMLTGVCSALAVMPAGGLVSLVF---RVSKVRNPRLPETV-----CHRVTYWSYW 1710

  Fly  1586 AFLIGLAIHVLFEV 1599
            .....|.::|::::
Zfish  1711 MHSFRLLVYVMYDL 1724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	75/434 (17%)
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	26/133 (20%)
pkd1l1	XP_021325910.1	PCC	<150..>300	CDD:188093	25/157 (16%)
		PCC	<228..540	CDD:188093	65/349 (19%)
		PLAT	1465..1579	CDD:320707	29/150 (19%)
		PKD_channel	2042..>2237	CDD:332708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010