DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42685 and pkd1l2b

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	XP_021333711.1	Gene:	pkd1l2b / 100537993	ZFINID:	ZDB-GENE-141222-87	Length:	1901	Species:	Danio rerio

Alignment Length:	1285	Identity:	227/1285 - (17%)
Similarity:	420/1285 - (32%)	Gaps:	447/1285 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 LIKGNERRLVDVRK--PIIIDGSS-------SKDRLKIRESI--KSKQFLWTCI---SLDDPFNN 544
            |:..::.|::|.::  .:.:|||:       |..||......  ...:|||:.:   |.:.||
Zfish    84 LVSTSDNRILDTQEDGSVWLDGSNVIYSNWFSGSRLSTGCGFINTDSRFLWSTMSNCSQELPF-- 146

  Fly   545 YCK----KYMS--KSPTL-----------------RLPPYALKENAVYDFSLTVISRFDPRNRMT 586
            .|:    .|:|  .|.||                 |.|.|..::|
Zfish   147 ICEFELGYYLSCMDSTTLQCGSAQVIEVEASYFGRRTPHYCRRDN-------------------- 191

  Fly   587 TTQTIKGVAKTTFTPQILCRRNCALGVYAPLDSIHLISKCDD---CPGTVKRYEWWLLDTESQPT 648
                   :...|.:|:     .|  |..:.||::  ...||.   |...|..:      .|..|.
Zfish   192 -------LTSVTDSPE-----RC--GWISVLDTV--AELCDGHQVCTADVSSF------GEPCPA 234

  Fly   649 LESSHKYLILHTLEPLVQIRLRVWVKGQGWADAFYTLRRNNGPQHGSCTIYPFLGVEGFTMFEID 713
            |.|   ||::.                       |..:..:........:||..
Zfish   235 LGS---YLLVE-----------------------YNCKDKSPHVILERAVYPLF----------- 262

  Fly   714 CPGFESPFPPITYRYMVSYGVVASNVPYSRIVLTLPAA------ETIMISI----CDAIDMCVE- 767
            .|...|..|.:.:   :.|   :||.....:.:|..:.      :||.:.:    ||.|...|:
Zfish   263 IPKRPSKTPAVNW---ICY---SSNNYQDSLTVTCSSCGETDNHDTIQLQLQNADCDDISWYVQD 321

  Fly   768 --KRVEVKVLSIDKSMLTGQKEVMNYVPNFFKRGHWNRAYIMGIAAITFIETSIDGDEFYSYLTG 830
              |..:.:..|..::.|..:.:|||  |   ::|: |..:.:...:|..::..:        |..
Zfish   322 GGKSKQSRKDSSKRNCLQKRNKVMN--P---QKGN-NEDFDIKANSIRPLKMDL--------LVL 372

  Fly   831 LVASTGSQMEQITTLSSHMLIRLHPVDFRGATVMAEMFSHLGDS-------------FSAIVQEH 882
            :....||.:...|....:.||::...:.:.| |.|:: |.:|.|             .|:::::.
Zfish   373 VSCKKGSAISYGTFTIQYSLIKMSKDEVKSA-VKAQL-SQIGTSLDTEQFKEDLLLQISSLLEDS 435

  Fly   883 EWLHREGYYSLTAMHMFFMSILGKKTESHSNAMCSLHNPACMNLQIIDLEKPFV--IKFDPLILV 945
            |.|......|.....:..:...||.|.:.......:.:....:|..|||....:  :.....::|
Zfish   436 EPLQPSDVQSYANDLVNIVKDEGKMTVAAQEYAGQILSVLGSSLTSIDLTPGNISALADTAALIV 500

  Fly   946 RINSWLMSTWFLYRCIYFLGVIATQRHHPYDDALTIHKSGIAYQINVTEVTENTKDIQVKTIDHI 1010
            :.:|            :.||.....:.                    :::|    :..:..:|.:
Zfish   501 QSSS------------HLLGAFDRDKE--------------------SDIT----NYLLSAVDSV 529

  Fly  1011 HVIKLSTKLLYELQRRLNHSSILLQIISQQNFHNIYWWYPDPFPSKTSVLIVHAYS--------- 1066
            |...|:.|.                              ||..|:..|...::.|:
Zfish   530 HTFLLANKT------------------------------PDQEPAVISTTNLNIYANRLSPHNLQ 564

  Fly  1067 --PVQFFRSAKEFQLTN----------PLVYKTNITHFN-------------DASFNQYMTNNS- 1105
              |.....|:..|:|.|          |:..|  :.|:|             .||.:...||.|
Zfish   565 KEPFAVVNSSASFKLPNLGSDILPVGEPVDVK--MAHYNIDPWAEGHPISSIVASMSLSKTNGSG 627

  Fly  1106 --IQNST-EVHIYSVMLNHKAMLAVRIVNCSELMYIKMRLHRWPTLGQIRQHACRITPDMQGKRI 1167
              :.|.| |:.|:...||      ...|:.|::           .||:.......||
Zfish   628 IPVANLTEEIEIFLPRLN------ASTVDTSDV-----------DLGRYSTTVINIT-------- 667

  Fly  1168 WIANSCERSPAYVAIHK--PGE-------IRYK---TEDKDQLSARGRKKGNRTHDGSETPEVRQ 1220
                    :|....:.|  |.|       :.|:   ||..::.:....::|| :.|...|..:..
Zfish   668 --------TPNITLVIKFSPSEDLTLLVLLGYQSQPTEGNNKATVTLPQQGN-SQDERYTWVLGP 723

  Fly  1221 KADFIDYD--NEDIVEEVLP----LNYSILLE--IYQCNIWKNRSLDPGWSEDHC-----TTSFE 1272
            .|..:|..  |..|..:|.|    :|.|:.:.  ..||..|:....:  ||:..|     ||.:
Zfish   724 DALALDVGVYNLLIRPKVPPGVKSINASVTVTSVTAQCIFWEEARAN--WSDYGCRVGPKTTPY- 785

  Fly  1273 HSRGSSVQCTCHTLGALSSRIFPI--------SSQLFVEHIPVPIFTFNMILMIFFALLFLLLVF 1329
                 ..||.|..|....:..|.:        |:|||..      |..|.:::.|...:|:..:
Zfish   786 -----VTQCLCTHLTFFGNSFFVMPNTVDPTKSAQLFSN------FAQNPVVVCFIGAIFVAFI- 838

  Fly  1330 KFLLHLNIISAYLKNPEFRLQCDASVGKSDQSFVSGSEILLV-IVTGGQEFAGTTSNVKFYLKSP 1393
                   :.:|:.:..:.:.:....|...|.:........|| |.||.:..:.|:|.|...::..
Zfish   839 -------LTAAWARRKDLKDKAKVKVTVLDDNDPFAEYCYLVKISTGHRPGSSTSSRVIVTVQGM 896

  Fly  1394 HRQQTSYQITQDPGHPKLLRNSTIKIMVPRGHIYIPTRL----ALRL--VPNGRYPSWYCRSITV 1452
            ......:.:| ||..|...|......:     :..|..|    ::||  ..:|.:|:|:..::.:
Zfish   897 EGDCEPHHLT-DPEKPVFERGGVDLFL-----LTTPYSLGDLQSIRLWHDNSGNHPAWFVSTVVI 955

  Fly  1453 VDLKLKVQQLFLVESWI---------------------EGGSHIQFMRSKYFTYGNYSRYPKYTW 1496
            .||:.:.:..||..||:                     :|.|::.|  ||..|          .:
Zfish   956 KDLQTEQKWNFLCNSWLSVDVDDCTVEKVFPVASEVDMKGFSNVFF--SKTTT----------DF 1008

  Fly  1497 CKRFRSRAEQLYFSWYLINAITGPSQSKVGGIIMNQFERTCVW---ICKTAITLAFVT--LYFGK 1556
            |.:         ..||  :.:..|..|..          |||.   .|.:.:..:.:|  :::|
Zfish  1009 CDK---------HLWY--SVVCRPVNSSF----------TCVQRVSCCFSVLLCSMLTSIMFYG- 1051

  Fly  1557 HTVSSIQEETRENVDNSLKVHLV---VMLGFFAFLIGLAIHVLFEVIILR 1603
                 |..:..|...:..::.|.   ||:||.:.|:...|:::...|..|
Zfish  1052 -----IPTDPSEQTMDMGQIQLTWSQVMIGFESTLLVFPINLIIVGIFRR 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	51/304 (17%)
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	29/140 (21%)
pkd1l2b	XP_021333711.1	CLECT	33..150	CDD:153057	16/67 (24%)
		Gal_Lectin	164..245	CDD:307994	22/148 (15%)
		GPS	759..798	CDD:307782	12/46 (26%)
		PLAT_polycystin	869..988	CDD:238850	26/124 (21%)
		PKD_channel	1437..1860	CDD:332708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010