DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42685 and pkd1

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	XP_017952982.2	Gene:	pkd1 / 100494429	XenbaseID:	XB-GENE-483409	Length:	4354	Species:	Xenopus tropicalis

Alignment Length:	1724	Identity:	324/1724 - (18%)
Similarity:	565/1724 - (32%)	Gaps:	575/1724 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 WRSAEAGKISFSERTRFTKMLSRKRHKIIRRTIPEEEERRIERLWDPVLNKS--YDFSSFEEY-- 111
            |.: |:..|...:|.:..|:|..|  |::      |...::....|.....|  |..:...:|
Frog  1877 WET-ESKNIIVQDRIQGLKLLVSK--KVV------EPGEKVNFTIDMTAGSSVTYKLTINGDYSI 1932

  Fly   112 --NTTTKTYPTIPSEKF----GLEDAARTYKNISEQKPGENSTHLFNDEDYSWSSVNTEISYGYE 170
              |:||.|:      :|    |.......:..:||::                .:|...:.....
Frog  1933 LLNSTTYTH------EFTKIGGYPVTVVAHNEVSEER----------------DTVMISVLEAIR 1975

  Fly   171 NQTYENGIEGSKSQNGNVSF--SLADFPLVD---EYPIYNQSSTCINNSSTEYQNQTVNDYNFAV 230
            :.|..|..||:.......||  .:::..||.   ::.:...|:|.:...:..|..:........:
Frog  1976 DLTIVNCCEGAMPVGVERSFIAEVSNGSLVAYTWQFDLQGHSTTSLAGKNVTYTPRAAGLLTIHL 2040

  Fly   231 PCLAPNVNGRTSS--VKNQQLLGQKGPLK-VYLFMNRNP-----------------VYGEEYSVF 275
            ..| .::.|...|  ::.|::: ::|.|| |..|:||:.                 ::|:...|.
Frog  2041 SAL-NDLGGLNISKIIRVQEMI-EEGRLKPVNTFVNRSVTFEAIVLPSSKDVVFLWMFGDGTPVQ 2103

  Fly   276 TTMPSLGKKNFAVNLTVDTNDYLIDEIHSD------WKYTKNLRKL----------------MRK 318
            .|.  .|:.|...::   ..||||....|:      :..|...|.|                ||
Frog  2104 ITY--FGQANHTYHM---PGDYLIKVNASNLINFVIFHLTVTTRVLECQEPLVKLALPPQVIMR- 2162

  Fly   319 WGIRSKR-IVYNRCYFHRCTARFYNTKHKYIVAKVSSLNDRRKLLAHVVRFKIKVRKPPNVSCLP 382
               ||:| .:......|.|.:  |.|||.:.:.:.:|
Frog  2163 ---RSQRNYIEAEIDLHNCFS--YQTKHLWEIYRAAS---------------------------- 2194

  Fly   383 ALELEFCKNPEKPVYFSPMGHLEFFASISDACSTVEYDKITWQLCDITENKIIARLKNATGLVVK 447
                  |.:.::|                        ||:..|..|::..:::         :.|
Frog  2195 ------CLHYQEP------------------------DKVNLQNVDLSRPQLV---------IPK 2220

  Fly   448 LLPYKVHILNEPDRRKVFLLRGKAVINGVTTVAR---CYMKYKPPPIEPLIKGNERRLVDVRKPI 509
            |      .|:..|...||     :|..|.|.::|   ..:...|..:.|:|.|...|:....:.:
Frog  2221 L------ALDIGDYCFVF-----SVTFGDTPLSRNSLANVTMMPSKLVPIIDGGSYRVWSKSRDL 2274

  Fly   510 IIDGSSSKDRLKIRESIKSKQFLWTCISLDDPFNNYCK-KYMSKSPTLRLPPYALKENAVYDFSL 573
            ::||:.|.|...:..|....::.|:|....:.....|. ::.|:...:.:|...|:....|.|.|
Frog  2275 VLDGNKSYDPNLVESSQTPLKYRWSCTFTKNSEAIRCPLEFSSEFGFMAIPKSMLQAEVEYTFFL 2339

  Fly   574 TVISRFDPRNRMTTTQTI---KGVAKTTFTPQILCRRNCALGVYAPLDS--IHLISKCDDCPGTV 633
            ||..  ...|..:|.||:   :|.........:.|:   |..||....|  ::|..:|.:|...
Frog  2340 TVSK--PGMNSESTNQTVLIKRGTVPIVSLKCVSCK---AQSVYEVSASSYVYLEGRCTNCLDD- 2398

  Fly   634 KRYEW---WLLDTESQPTLESSHKYLILHTLEPLVQIRLRVWVKGQGWADAFYT----------- 684
               .|   |...:....||............|..:.:||.....|||:....:.
Frog  2399 ---SWSARWTAQSFDNKTLPLDSSTTSTGDREMNLVLRLGALKDGQGYTFTLHVIHPSMDEEGFA 2460

  Fly   685 ---LRRNNGPQHGSCTIYP---FLGVEGFTMFEIDCPGFESPFPPITYRYMVSYGVVASNVPYSR 743
               |..|:.|..|||||.|   ...:.|...||  |.|:.
Frog  2461 SIDLLPNSPPSGGSCTIAPNGTVHALPGKIHFE--CTGWR------------------------- 2498

  Fly   744 IVLTLPAAETIMISICDAIDMCVEKRVEVKVLSIDKSMLTGQKEVMNYVPNFFKRGHWNRAYIMG 808
                            ||.|       |...|            |.:.:....|.||.
Frog  2499 ----------------DAED-------EAGSL------------VFSLIVRRCKPGHC------- 2521

  Fly   809 IAAITFIETSIDGDEFYSYLTGLVASTGSQMEQITTLSSHMLIRLHPVDF-----------RGAT 862
                         :||:.|       .||:.|.    |:|:....|..||           :||.
Frog  2522 -------------EEFWVY-------KGSRSEH----STHLPTGFHESDFAVDVSVVVQDQQGAA 2562

  Fly   863 VMAEMFSHLGDSFSAIVQEHEWLHREGYYSLTAMHMFFMSILGKKTESHSNAMCSLHNPACMNLQ 927
            .:|     |..|.:.::.:..    ||:.|||  |.     |..:|||      :||.      .
Frog  2563 AVA-----LNRSMNVLLPDVS----EGFSSLT--HW-----LRNQTES------TLHG------L 2599

  Fly   928 IIDLEKPFVIKFDPLILVRINSWLMSTWFLYRCIYFLGVIATQ-----RHHPYDD------AL-- 979
            :|..:...|.:|...::..:|.:....:.:...::.:....|:     :.:..||      ||
Frog  2600 LIQGDPQHVTEFSLALITILNEYESMNYEVEPDLHIVRQNITEALISLKVNTVDDIRKIAAALAQ 2664

  Fly   980 ----------------TIHKSGIAYQINVTEVTENTKDIQVKTI---------DHIHVI------ 1013
                            |:.|......|...|.|:.|  :...||         |.||::
Frog  2665 CTVASKKLECAACQVHTLSKLETMMSILQNETTQGT--MTPTTIADNILNIMGDLIHLVNTNPPR 2727

  Fly  1014 --------------------KLSTKLLYEL--QRRLNHSSILLQ---------------IISQQN 1041
                                .||:.|:..|  .|.||...:.||               ::...|
Frog  2728 YKHGKLCAGDKSLAVASKAYNLSSDLMRILMKSRVLNEEPLTLQGGEILARGKRSDPLNLLCYSN 2792

  Fly  1042 FHNIYWWYPDPF----PSKTSVLIVHAYSPVQFFRSAKEFQL-TNPLVYK--TNITHFNDASFNQ 1099
            .....::.|..|    |..|.::.|             .||: :||..|.  |:.|.....:..:
Frog  2793 QTGCQFFIPHGFNSALPDLTDIIQV-------------MFQVDSNPYPYGFITDYTVSTKVASME 2844

  Fly  1100 YMTNNSIQNSTEVHIYSVMLNHKAMLAVRIVNCS-------------ELMYIKMRLHRWPTLGQI 1151
            :.|:|..|...|      .|:.:..:.|||.|.|             ....:|:.:....:.|..
Frog  2845 FHTSNGSQIPVE------SLDSEKAITVRIDNNSGDRNITAGVATIERRRSVKVDVEANSSNGNA 2903

  Fly  1152 RQHACRITPDMQGKRIWIANSCERSPAYVA-IHKPGE-IRYKTEDKDQLSARG-RKKGNRTHDGS 1213
            |.| .::|..:|..|..::   |..|...| :|:.|. .:|...|..|:..:. .::.::.:...
Frog  2904 RLH-IQVTYVVQDDRYVLS---EPEPFITAYLHESGHPNQYNCTDMKQIGMKDLSRQDHKLYTFF 2964

  Fly  1214 ETPEV--RQKADFIDYDNEDI---VEEVLPLNYSILLEIYQCNIWKNRSLDPGWSEDHCTTSFEH 1273
            ..|..  ..:..:::..|..:   |:..:.| |:.|.:.:..|  :|:     ||.|......:.
Frog  2965 LVPTTGNHSRHYYLNITNHYMWTSVDVTVGL-YTSLCQYFDGN--ENK-----WSTDGVFPLNDT 3021

  Fly  1274 SRGSSVQCTCHTLGALSSRIFPISSQLFVEHIPVPIFTFNMILMIFFALLFL------LLVFKF- 1331
            ..|.:|..|.|.....:|...|..|.:|:...|.|  ..|.|:::..|:.|:      ::|.|.
Frog  3022 RPGQAVCLTRHLTAFGASLFVPPHSVVFIHPPPPP--GINYIVLLTCAVCFVTYSVATIIVHKLD 3084

  Fly  1332 LLHLN---IISAYLKNPEFRLQCDASVGKSDQSFVSGSEILLVIVTGGQEFAGTTSNVKFYL--- 1390
            ||.:|   :|....|...|:.:                   :::.||....:|||::|...|
Frog  3085 LLDVNKAGVIPFCGKAGSFKYE-------------------VLVKTGWGRGSGTTAHVGISLYGV 3130

  Fly  1391 --KSPHRQQTSYQITQDPGHPKLLRNST--IKIMVPR--GHIYIPTRLALRLVPNGRYPSWYCRS 1449
              ||.||..        .|.....|||.  .:|...:  |:::   ::.|.....|..||||.:.
Frog  3131 DYKSGHRHL--------DGDNTFHRNSVDIFQIATEKSLGNVW---KIRLWHDNKGLSPSWYVQH 3184

  Fly  1450 ITVVDLKLKVQQLFLVESWI-----EGGSHIQ---FMRSKYFTYGNYSRY----------PKYTW 1496
            :.:.||:.|.:..||:..|:     |.|..::   |..|: .....:||.          .|:.|
Frog  3185 VIIRDLQSKKEYFFLMNDWLSVGREESGRRVEREIFAASE-MELKRFSRIFVAEVQRGVSEKHVW 3248

  Fly  1497 CKRF----RSRAEQ---------LYFSWYLINAI 1517
            ...:    |||..:         |.|.:...||:
Frog  3249 LSMWDRPPRSRFTRVQRATCCALLIFLFLCANAV 3282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	72/370 (19%)
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	32/129 (25%)
pkd1	XP_017952982.2	LRR_8	<83..114	CDD:404697
		leucine-rich repeat	83..103	CDD:275378
		leucine-rich repeat	104..127	CDD:275378
		PCC	108..2722	CDD:188093	200/1098 (18%)
		leucine-rich repeat	128..140	CDD:275378
		GPS	2996..3045	CDD:413374	13/55 (24%)
		PLAT_polycystin	3103..3222	CDD:238850	33/148 (22%)
		PKD_channel	3699..4102	CDD:400395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010