DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42685 and pkd1l2

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	XP_031756633.1	Gene:	pkd1l2 / 100486136	XenbaseID:	XB-GENE-968335	Length:	2458	Species:	Xenopus tropicalis

Alignment Length:	1945	Identity:	343/1945 - (17%)
Similarity:	613/1945 - (31%)	Gaps:	705/1945 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 FLEAYNRSTESP-------------------EGGPTSHPWRSAEAGKISFSERTRFTKMLSRKRH 76
            ||..|:.:..||                   ....::..|.....|.::|.:        :::..
Frog    10 FLAPYSHADPSPCSKYQVLFNSSCYEFVRLERNFHSAQKWCERGGGHLTFID--------NQETQ 66

  Fly    77 KIIRRTIPEEEERRIERLWDPVLNKSYDFSSFEEYNTTTKTY-----PTIPSEKFG--------- 127
            :.:...:.|:.|..|..::.||.:....|.::.:.:..|.:|     |....:|.|
Frog    67 EFLGTYLSEDREWWIGLIYTPVNDSGQGFMTWLDASNLTFSYWHNGDPPETEKKCGYLRRQSGYH 131

  Fly   128 -------------------------------LEDAARTYKNISEQKPGENSTHLFNDEDY----- 156
                                           |:..:.....||:...|..|.|....|::
Frog   132 WSTTDNCRQELFFICQFEFGHTISCENQNATLQCGSGEVVQISDSYYGRRSPHFCTQEEHSQITS 196

  Fly   157 --SWSSVNTEI-------------------------SYGYENQTYENGIEGSKSQ---------- 184
              ||::|...:                         |..|.:..| |.|||.:.:
Frog   197 GCSWTNVKDLVAAQCQGLQACQITTDSSLFGTPCPTSGSYLSIDY-NCIEGLQIELPDKCLVGEN 260

  Fly   185 ------------NGNVS--FSLADFPLVDEYPIYNQSSTCINN-------------SSTEY---- 218
                        .||:|  .|:.|...:|.|...|.|||..::             |::|:
Frog   261 MTLTVNWLLSPYTGNLSCIISIEDGYSIDPYQPINVSSTVTHSFTLPGEFAVFVECSTSEWHVTA 325

  Fly   219 -QNQTVNDYNFAVPCLAPNVNGRTSSVKNQQLLGQK-GPLKVYLFMNRNPVYGEEYSVFTTMPSL 281
             :..||.::...:     |:.|..|.      .|.| |....|        |||...:...:.:.
Frog   326 QKTITVEEHRAVL-----NITGCYSK------FGSKNGVCSTY--------YGETLWIQVEISTG 371

  Fly   282 GKKNFAVNLTVDTNDYLIDEIHSDWKYTKNLRKLMRKWGIRSKRIVYNRC--YFHRCTARFYNTK 344
            |:    ||.|:.:|:.::.:..:.   |::|     .:.:...|:..|..  ..||......:.:
Frog   372 GE----VNYTLLSNNIILSQFRAK---TEDL-----TYNLTLDRVAQNLMGPGLHRLMIMASSNE 424

  Fly   345 HKYIV---AKVSSLNDRRKLLAHVVRFKIKVRKPPNVSCLPALELEFCKNPEKPVYFSPMGHLEF 406
            ..:|.   ..|..:.....|||.:..|.::|.....::...|             |.:|: :|.|
Frog   425 IPFITPGNITVHLIEPVSGLLAELCNFVLEVGTELKINLSIA-------------YGAPV-NLMF 475

  Fly   407 FASISDACSTVEYDKI-----------------TWQLCDITENKIIARLKNATGLVVKLLPYKVH 454
              :|.|...|..|.:.                 |:.:..:..|......||...:.|....|...
Frog   476 --NIIDVNKTFSYTRENSSGEQQIYTIPVEAEGTYMVTVVAFNSFSNFSKNLGNITVLNSAYNNT 538

  Fly   455 ILNEPDRRKVFLLRGKAVINGVTTVARCYMKYKPPPIEPLIKGNERRLVDVRKPIIIDGSSSKDR 519
            .|.:.:.:.          ..||.:.:....::   |||      .|.|:....|::....|
Frog   539 GLQDTEGKN----------ENVTVIVKRTQAFR---IEP------SRYVNPFTSIVLHWPDS--- 581

  Fly   520 LKIRESIKSKQFLWTCIS------------LDDPFNNYCKKYMSKS---PTLRLPPYALKENAVY 569
              :..:|.     |||.|            |.||        :|::   |...|||    .|..
Frog   582 --VGSNIS-----WTCGSCWPGWFECVEQNLIDP--------LSENILIPANCLPP----PNTA- 626

  Fly   570 DFSLTVISRFDPRNRMTTTQTIKGVAKTTFTPQILCRRNCALGVYAPLDSIHLISKCDDCPGTVK 634
             |::....|...:..:...|.:...||:|...:|.|:.||.   ...||...:.|...|...|..
Frog   627 -FTVLATDRASEKEILQDEQCLYVTAKSTLPIKISCKANCK---EISLDEDMVFSATCDNKATFS 687

  Fly   635 RYEWWLLDTE------SQP--------------TLESSHKYLILHT------LEPLVQIRLRVWV 673
                |.|||.      |.|              .|:.:...|:|::      .....:|:| :.:
Frog   688 ----WYLDTNFPKMTLSPPDACQHRDFRQSSLVLLQKNTSTLVLNSTFLKTQTNTAFRIKL-IAM 747

  Fly   674 KGQGWADAFYTLRRNNGPQHGSCTIYPFLGVEG--FTMFEIDC---------------------- 714
            ..|.:.:....:.....|:...|||:|   .||  .:.|:|.|
Frog   748 NSQEYGEDTLVVSTVPPPEVPRCTIHP---EEGSVLSTFQISCRAPCASTNSCIGDEQVTLTYCI 809

  Fly   715 -----------PGFESP--FPPITYR---YMVSYGVVASNVPYSRIVLTLPA---AETIMISICD 760
                       |..|.|  |.|:..:   ::::..|..||:..:.:..||..   .:.|..:...
Frog   810 YPKPNSQLYCGPDSELPSIFLPMGEKENDFILNLTVTVSNMYGTSVNTTLKVKVRQDEINTNSQT 874

  Fly   761 AIDMCVEKRVEV-KVLSIDKSMLTGQKEVMNYVPNFF------------KRGHWNRAYIMGIAA- 811
            .:.:..||...: |...:..|::...|.|.:.:....            ::.......:..::|
Frog   875 LVSLVSEKSANILKGDGVGSSLIQLYKSVSSVLNQKIPEDSDSNPLQTEEKKELREVMLTALSAV 939

  Fly   812 -ITFIETSIDGDEFYSYLT--GLVASTGSQMEQITTL----SSHMLIRLHPVDFRGATVMAEMFS 869
             ||.:.|:::..|..:.||  ....|..:|:|..:.|    .|.:.:|..|.:.|     .|...
Frog   940 NITSLHTALEMSEVLNDLTTRNEELSASAQVEASSALKGISESLLTVRSEPEETR-----KEAVQ 999

  Fly   870 HLGDSFSAIVQ-----EHEWLHREGYYSLTAMHMF-------FMSILGKKTESHSNAM----CSL 918
            ||.::.|.:::     ...........|..::|:.       ...::||..::....:    .|:
Frog  1000 HLFNAVSNVLEATALDSSRMAPDMAAQSAVSLHLLGAVENLQSALLMGKLPDNEPTILTAPSASM 1064

  Fly   919 H----NPACMNLQIIDLEKPFVIKF--------------DPLILVRINSWLMSTWFLYRCIYFLG 965
            :    .|..:....::::.|....|              :..:.:|:.|:|:
Frog  1065 YINRMKPGHLQGTSVNIKDPSTAAFTLPSLSSLSIPIGNEDAVDLRMVSFLV------------- 1116

  Fly   966 VIATQRHHPYDDALTIHKSGIAYQINVTEVTENTKDIQVKTI-DHIHVI--KLS----TKLLYEL 1023
                   :|:..:.|...||....:::|  :.:...|.||.: :||.:|  :.|    .|.:..|
Frog  1117 -------NPFSSSNTFDISGSVGGLSLT--SPDGSVIPVKDLTEHIEIILPRFSELEDEKSILSL 1172

  Fly  1024 QRRLNHSSILLQIISQQNFHNIYWWYPDPFPSKTSVLIVHAYSPVQFFRSAKEFQLTNPLVYKTN 1088
               :|.:|:|:.:.|..|                 .|:||       ...::|..|...|.|
Frog  1173 ---VNFTSLLINVTSSVN-----------------SLVVH-------LEPSEEIPLVLYLGY--- 1207

  Fly  1089 ITHFNDASFNQYMTNNSIQNSTEVHIYSVMLNHKAMLAVRIVNCSELMYIKMRLHRWPTLGQIRQ 1153
                      :|..|.:..:.| .|:.|.|.|.:.:.: .::...||::
Frog  1208 ----------EYQPNETNYDIT-THLPSKMYNRENIYS-WVIGPEELLF---------------- 1244

  Fly  1154 HACRITPDMQGKRIWIANSCERSPAYVAIHKPGEIRYKTEDKDQLSARGRKKGNRTHDGSETPEV 1218
                                            ||..|....:.:|.
Frog  1245 --------------------------------GEGTYYLIVRSELE------------------- 1258

  Fly  1219 RQKADFIDYDNEDIVEEVLPLNYSILLEIYQCNIWKNRSLDPGWSEDHC-----TTSFEHSRGSS 1278
                |....||..||         :.....||..|...:.|  |:...|     ||.      ||
Frog  1259 ----DLTPNDNLTIV---------VTCFSTQCMFWDEANQD--WNSTGCHVGPKTTP------SS 1302

  Fly  1279 VQCTCHTLGALSSRIFPISS--------QLFVEHI--PVPIFTFNMILMIFFALLFLLLVFKFLL 1333
            .||.|:.|....|....:.:        :||...:  ||.:.|...|     ||:::|:
Frog  1303 TQCLCNHLTFFGSSFIVMPNAVDVSRTVELFATFVDNPVVVTTVGCI-----ALVYVLV------ 1356

  Fly  1334 HLNIISAYLKNPEFRLQCDASV---GKSDQSFVSGSEILLVIVTGGQEFAGTTSNVKFYLKSPHR 1395
               :|.|..|:    :|.:|.|   ...|....:....|:.:.||.:..|.|||.|...|.....
Frog  1357 ---MIWARRKD----IQDNAKVKIIALEDNDPFAQYRYLVTVFTGHRRGAATTSKVTITLYGSDG 1414

  Fly  1396 QQTSYQITQDPGHPKLLRNS----TIKIMVPRGHIYIPTRLALRL--VPNGRYPSWYCRSITVVD 1454
            :...:.:: ||..|...|..    .:..:.|.|.:.     .:||  ..:|..||||...:.|.|
Frog  1415 ESDPHHLS-DPEGPVFERGGEDIFLLTTLFPLGDVQ-----TIRLWHDNSGDKPSWYVNRVLVHD 1473

  Fly  1455 LKLKVQQLFLVESW--IEGG-------------------SHIQFMR-SKYFT-----YGNYSRYP 1492
            ::|..:..||..||  ||.|                   |::.||: ||.|.     |..:||.|
Frog  1474 MELDQKWYFLCNSWLSIEVGDCVLDKVFSVATEEDMKQFSNLFFMKTSKGFRDGHIWYSVFSRSP 1538

  Fly  1493 KYTWCKRFRSRAEQLYFSWYLINAITG---------PSQSKVGGIIMNQFERTCVWICKTAITLA 1548
            :.::.   |.:.....||..|...:|.         |::.|:.   |.:.|.|  |
Frog  1539 RSSFT---RVQRVSCCFSLLLCTMLTSIMFWGVPTDPAEQKMD---MGKIEFT--W--------- 1586

  Fly  1549 FVTLYFGKHTVSSIQEETRENVDNSLKVHLVVMLGFFAFLIGLAIHVLFEVIILRWLWPQ 1608
                          ||               ||:||.:.|:...|::|. |.|.|.:.|:
Frog  1587 --------------QE---------------VMIGFESSLLMFPINLLI-VQIFRNIRPK 1616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	80/442 (18%)
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	35/140 (25%)
pkd1l2	XP_031756633.1	CLECT	22..147	CDD:214480	14/132 (11%)
		Gal_Lectin	163..243	CDD:396628	13/80 (16%)
		REJ	<615..890	CDD:366875	56/291 (19%)
		GPS	1276..1314	CDD:396408	14/45 (31%)
		PLAT_polycystin	1385..1504	CDD:238850	32/124 (26%)
		PKD_channel	1988..2408	CDD:400395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010