DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42685 and Pkd1l3

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	XP_038954217.1	Gene:	Pkd1l3 / 100362565	RGDID:	2324490	Length:	2183	Species:	Rattus norvegicus

Alignment Length:	845	Identity:	165/845 - (19%)
Similarity:	272/845 - (32%)	Gaps:	247/845 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   809 IAAITFIETSIDGDEFYSYLTGLVASTGSQMEQITTL----SSHMLIRLHP-VDFRGAT--VMAE 866
            |..:|.:|::|              .||..:..||..    |...:|..|| :.|:.:|  |:.|
  Rat   590 ITEVTRLESTI--------------PTGRSLADITLNAKEDSPPGVISTHPQMSFQSSTNQVIEE 640

  Fly   867 MFSHLGDSFSAIVQEHEWLHREGYYSLTAMHMFFMSILGKKTESHSNAMCSLHNPA--CMNLQII 929
            ....|     .:.......|.|...:.:.:......:....|.:..|...|.|.||  |
  Rat   641 TAGKL-----ILANPASQAHSEFQKACSILQRLRDFLPTSSTSAQRNNSWSSHTPAVSC------ 694

  Fly   930 DLEKPFVIKFDP---LILVRINSWLMSTWFLYRCIYFLGVIATQRHHPYDDALTIHKSGIAYQIN 991
                    .|.|   |:..:.||..|:.             ......|.|:|.|      |:.||
  Rat   695 --------PFQPLGSLLTTKKNSHQMAQ-------------QDTEQRPIDEAYT------AFGIN 732

  Fly   992 VTEVTENTKDIQVKTIDHIH-VIKLSTKLLYELQRRLNHSSILLQ------------IISQQNFH 1043
             :|....|.|:::::...:. :::.|...|.|:.|.....|:..|            ::|.||..
  Rat   733 -SEGPTFTSDVRLQSEFEVEDMLETSLMALGEIHRTFCQQSLCPQSAVTLASPTATLVLSSQNVS 796

  Fly  1044 NI-----YWWYPDP----FPSKTS---VLIVH----------AYSPVQFFRS------------A 1074
            ::     ....|.|    |||..:   :|..|          |::|.:....            :
  Rat   797 SLPLSTYTLGEPAPLRLGFPSAEALKELLDKHPGVNLQVTGLAFNPFETSDDSNIVGSIGNVLLS 861

  Fly  1075 KEFQL--TNPLVYKTNITHFNDASFNQYMTNNSIQNSTEVHIYSVMLNHKAMLAVRIVNCSELMY 1137
            .|:||  .:.|:....|..:.:||.....|  |:..||:  .:::.:|..::....||.......
  Rat   862 SEYQLIRVHDLIEDIEIVLWRNASMETQPT--SLNTSTD--CFTISVNITSLEKTLIVTIEPESP 922

  Fly  1138 IKMRLHRWPTLGQIRQHACRITPDMQGK------------RIWIANSCERSPAYVAIHKPGEIRY 1190
            :.|.||    ||         ..|..|.            ::|     ::...|..:..|..:.|
  Rat   923 LLMTLH----LG---------FQDKPGHTHFYLNISLPRGQVW-----QKDEEYTWVLTPESLWY 969

  Fly  1191 KTEDKDQLSARGRKKGNRTHDGSETPEVRQKADFIDYDNEDIVEEVLPLNYSILLEIYQCNIWK- 1254
            .|.....::...:......|                          .|:..|::..:.||..|.
  Rat   970 GTGTYYIMAVENKSAETAQH--------------------------TPVLVSVVTAVTQCYFWDR 1008

  Fly  1255 -NRSLDPGWSEDHCTTSFEHSRGSSVQCTCHTLGALSSRIFPISSQLFVEHIPVPIFTFNMILMI 1318
             ||:    |..|.|... ..|.....||.|..|...||..|.:...:.||:      |..::|.:
  Rat  1009 YNRT----WKSDGCQVG-PKSTILKTQCLCDHLTFFSSDFFIVPRTVDVEN------TIKLLLHV 1062

  Fly  1319 F-----FALLFLLLVFKFLLHLNIISAYLKNPEFRLQCDASVGK----SDQSFVSGSEILLVIVT 1374
            .     .:||..||.|..||   ...|:.|:     |.|....|    :|....|....|:.:.|
  Rat  1063 SNNPVGVSLLASLLGFYILL---ATWAWRKD-----QADTQKVKVTVLADNDPSSAFHYLIQVYT 1119

  Fly  1375 GGQEFAGTTSNVKFYLKSPHRQQTSYQITQDPGHPKLLRNSTIKIMVPRGHIYIPTRLALRL--V 1437
            |.:..|.||:.|...|.........:.:. ||......|.:....::..|. ::.....|||  .
  Rat  1120 GYRRRAATTAKVVITLYGSEGHSEPHHLC-DPQKTVFERGALDVFLLSTGS-WLGDLHGLRLWHD 1182

  Fly  1438 PNGRYPSWYCRSITVVDLKLKVQQLFLVESWIEGGSHIQFMRSKYFTYGNYSRYPKYTWCKRFRS 1502
            .:|..||||...:.|.|:.:|.:..|....|:.            ...||..|...:|...|...
  Rat  1183 NSGNSPSWYVSQVVVSDMTVKKKCHFQCNCWLA------------MDLGNCERDRVFTPASRSEL 1235

  Fly  1503 RAEQLYFSWYLINAIT-----------GPSQSKVGGIIMNQFER----TC---VWICKTAITLAF 1549
            .:.:..||..::...|           .|         .|||.|    :|   :.:|...|.:.|
  Rat  1236 SSFRHLFSSTIVEKFTQDYLWLSVATRHP---------WNQFTRVQRLSCCMTLLLCDMVINVMF 1291

Fly 1550 1549
Rat 1292 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	25/114 (22%)
Pkd1l3	XP_038954217.1	CLECT	37..144	CDD:153057
		Herpes_BLLF1	<215..601	CDD:282904	4/24 (17%)
		GPS	1002..1040	CDD:396408	13/42 (31%)
		PLAT_polycystin	1111..1230	CDD:238850	29/132 (22%)
		PKD_channel	1688..2096	CDD:400395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I10909
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010