DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42685 and pkd1a

DIOPT Version :9

Sequence 1:	NP_609717.5	Gene:	CG42685 / 34854	FlyBaseID:	FBgn0261571	Length:	1609	Species:	Drosophila melanogaster
Sequence 2:	XP_021333081.1	Gene:	pkd1a / 100149562	ZFINID:	ZDB-GENE-100707-1	Length:	4625	Species:	Danio rerio

Alignment Length:	1506	Identity:	278/1506 - (18%)
Similarity:	483/1506 - (32%)	Gaps:	484/1506 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 TARFYNTKHKYI-----VAKVSSLNDRRKLLAHVVRFKIKVRKPPNVSCLPALELEFCKNPEKPV 396
            ||.|:|  |.|:     |.:|:..|     |...|..:|:|    |:|.|.      |..||..:
Zfish  2162 TAPFHN--HVYLIPGHYVVRVNVSN-----LVSWVTAQIEV----NISVLK------CDEPEVQI 2209

  Fly   397 YFSPMGHLEFF--------ASIS-DACST--VEYDKITWQL-----CDITENKIIARLKNATGLV 445
            ..:|  .|..:        ||:: ..|..  |||   .|::     |...:.|
Zfish  2210 IQAP--RLAIWRHQPTLVEASVNLKGCVLYGVEY---LWEILTSPRCQDDDKK------------ 2257

  Fly   446 VKLLPYKVHILNEPDRRKVFLLRGKAVINGVTTVARCYMKYKPPPIE---------------PLI 495
             ...|.|:.:..|.:.|::.|...|..|..........:.|:..|:.               |:|
Zfish  2258 -GPPPSKIQLPPEVNVRRLQLSVPKISIPAGNYTLVFSLSYEGVPLRKAACLQLSVMSKKLVPII 2321

  Fly   496 KGNERRLVDVRKPIIIDGSSSKDRLKIRESIKSKQFLWTCISLD-DPFNNYCKKYM----SKSPT 555
            :|...|:......:.:....|.|.....|:.....:.|.|:|.. .|  ::|....    ...|.
Zfish  2322 EGGTYRVWSKTHDLDLSAEQSYDPNLDPENQVPLSYHWECVSTSKGP--DHCSTLHFGLGPSDPV 2384

  Fly   556 LRLPPYALKENAVYDFSLTVISRFDPRNRMTTTQTI---KGVAKTTFTPQILCRRNCALGVYAPL 617
            |.:....|:.:..|.|.|||..  |.....:||||:   .|.........:.|:......: :..
Zfish  2385 LGISGSELEVDVEYTFRLTVSK--DGMAPESTTQTVCVQSGRIPMVSLKCVSCKAQSRYEI-SQS 2446

  Fly   618 DSIHLISKCDDCPGT--------VKRYEWWLLDTESQPTLESSHKYL----ILHTLEPLVQIRLR 670
            ..::|...|.:|..:        .:|.|..:||..:..|...|.:.:    ||...|..: ..|.
Zfish  2447 SYVYLAGHCSNCQSSHRGRWTAMTRRNETLVLDLNTTTTGSDSMRLVLRQGILRDRESYI-FSLH 2510

  Fly   671 VWVKGQGWAD-AFYTLRRNNGPQHGSCTIY-PFLGVEGFTMFE---IDCPGF---ESPFPPITYR 727
            |...|..... |:..|..|..|..|:|::: ...|.:..|:.|   .:|.|:   :....|:.|.
Zfish  2511 VTDDGMDREGVAYIELHPNLPPDGGACSLWADGGGTQVQTLLERVHFNCSGYTDLDETESPLVYS 2575

  Fly   728 YMV---------SYGVVASNVPYSRIVLTLPAAETIMISICDAIDMCVEKRVEVKVLSIDKSMLT 783
            .:|         .:.|.....|.....|. |...:....:  ::.:.||......:|:.:.||
Zfish  2576 LLVVRCSELYCEEFYVYKGTSPEHSAFLP-PGFSSAQYRV--SVLVMVEDHQGASILARNTSM-- 2635

  Fly   784 GQKEVMNYVPN-FFKRGHWNRAYIMGIAAITFIETSIDGDEFYSYLTGLVASTGSQMEQITTLSS 847
              :.|:..||: |....||    :..:.|.|..|....||.                :::..||.
Zfish  2636 --EVVLPVVPDGFVSLPHW----LSNVTASTLRELLRQGDS----------------QRVRELSL 2678

  Fly   848 HMLIRLHPVDFRGATVMAEMFSHLGDSFSAIVQEHEWLHREGYYSLTAMHMFFMSILGKKTESHS 912
            .::..|:..: :|.:...|..|.....:...::.:  :.|    :||::.:..:|.:  :..|.:
Zfish  2679 ALITVLNEYE-QGVSRRRERVSKSERQYRVSIRGN--ITR----ALTSLDLTTVSDI--QQTSAA 2734

  Fly   913 NAMCSLHN-----PACMNLQIIDLEKPFVIKFDPLILVRINSWLMSTWFLYRCIYFLGVIATQRH 972
            .|.|:..:     ..|.|..:..||.                             .|.::.|..
Zfish  2735 LAQCTAVSREFVCEECQNSTLDKLES-----------------------------MLEILQTDT- 2769

  Fly   973 HPYDDALTIHKSGIAYQINVTEVTENTKDIQVKTIDHIHVIKLSTKLLYE------------LQR 1025
                      |.|   .:..||:.:|..:|....|..::.:..|.....|            ||.
Zfish  2770 ----------KQG---TVTPTEIADNILNIMGDLIHQVNQVASSPPPEAEDQDGSVSQQPPFLQE 2821

  Fly  1026 RLNH------------SSILLQII---------------------------------------SQ 1039
            .|.|            ||:|::|:                                       ..
Zfish  2822 ELQHHPLRVAAKAYTLSSVLMRILMLGRVLNEEPLILRGAEIAAVGKRADPQSLLCYGESDAPEC 2886

  Fly  1040 QNFHNIYWWYPDPFPSKTSVLIVHAYSP------VQFFRSAKEFQLTN---PLVYKTNITHFNDA 1095
            |.|.     .|.||.|........|.:|      ||..     ||:..   |..|..|.....:.
Zfish  2887 QGFS-----IPRPFNSSLGRAAEGALAPNSDDGIVQLL-----FQVEPNPFPFNYVDNYPVSTEV 2941

  Fly  1096 SFNQYMTNNSIQ----NSTEVHIYSVMLNH-----------KAML----AVRIVNCSELMYIKMR 1141
            :..::.|.|..|    :..|....:|.:|:           ||:|    ||.|..|..::.
Zfish  2942 ASMEFRTVNGTQIPIADLDESQAITVAVNNGSATGLDASGLKAVLPPAGAVNISRCDSIIV---- 3002

  Fly  1142 LHRWPTLGQIRQHACRI---------TPDMQGKRIWIANSCERSPAYVAIHK-PGEIRYKTEDKD 1196
              |..|....||....|         |||.     ||.       ||:...: |.|  :.:.|:.
Zfish  3003 --RVNTRNTNRQAGVYIQLNFTVLDDTPDS-----WIT-------AYLDTSEWPNE--FNSTDRK 3051

  Fly  1197 QLSARGRKKGNRTHDGSETPEVRQKADFIDYDNEDIVE---------------EVLPLNYSILLE 1246
            :::....::.:..|        |....|:..:..|..:               |:|.|..::...
Zfish  3052 RITLNMTRRPDLHH--------RDYTFFLSPNVYDTTQDHFINVSSGCGTAEPELLRLEVAVFTS 3108

  Fly  1247 IYQCNIWKNRSLDPGWSEDHCTTSFEHSRGSSVQCTCHTLGALSSRIF-PISSQLFVEHIPVPIF 1310
            :  |..:...:..  |..|......|.|.|.:| |..|.|.|.::.:| |..:..|:    :|..
Zfish  3109 L--CQYFSESAKQ--WRTDGMEPLAETSVGQAV-CRTHHLTAFAASLFVPPDAVSFI----IPER 3164

  Fly  1311 TFNMILMIFFALLFLLLVFKFLLHLNIISAYLKNPEFRLQCDASVGKSDQSFVSGSEIL------ 1369
            :.:..:::....:..||.:.      :..|.|:             |.||..:..:.::
Zfish  3165 SVSRSVVVVLVCVVSLLCYA------VAGAVLR-------------KLDQMDLRRASVVPLCGKD 3210

  Fly  1370 ------LVIVTGGQEFAGTTSNVKFYL-----KSPHRQQTS-----------YQITQDPGHPKLL 1412
                  :.:.||....||||::|...|     :|.||...|           :.|..|..
Zfish  3211 GLYKYEIQLKTGWSPGAGTTAHVGISLHGSEGRSGHRHLDSVGAFARNSLDIFHIASDSS----- 3270

  Fly  1413 RNSTIKIMVPRGHIYIPTRLALRLVPNGRYPSWYCRSITVVDLKLKVQQLFLVESWI-------E 1470
            ..|.:||.:...:             .|..|:|..:.:.|.||:......||:|.|:       :
Zfish  3271 LGSVLKIRLWHDN-------------KGLSPAWLLQYVLVKDLQTGSSFFFLIEEWLSVDNEKTD 3322

  Fly  1471 GGSHIQFMRSKYFTYGNYSRYPKYTWCKRFRSRAEQLYFSWYLINAI----------TGPSQSKV 1525
            |...|:...|:..    |.|    .|.:..|         |.|..|:          ..||:|.
Zfish  3323 GRVEIEVEASEEL----YLR----DWPRLLR---------WELQRAVCESHVWLSLWERPSRSP- 3369

  Fly  1526 GGIIMNQFER-TCVWICKTAITLAFV--TLYFG----KHTVSSIQEETRENVD-------NSLKV 1576
                ..:.:| ||   |...:.|..:  .:::|    ||:...:.:....||:       :.|.|
Zfish  3370 ----FTRLQRLTC---CSLLLHLQMLAAAVWYGTVSYKHSSVPVADLVSVNVETLWAGMVSCLLV 3427

  Fly  1577 HLVVMLGFFAF 1587
            :.:.:|.|..|
Zfish  3428 YPLYLLVFCLF 3438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42685	NP_609717.5	REJ	411..753	CDD:307914	76/401 (19%)
CG42685	NP_609717.5	PLAT	1367..1480	CDD:238061	29/147 (20%)
pkd1a	XP_021333081.1	LRR	<68..>167	CDD:227223
		leucine-rich repeat	88..110	CDD:275378
		leucine-rich repeat	111..133	CDD:275378
		leucine-rich repeat	134..157	CDD:275378
		PCC	138..2795	CDD:188093	141/752 (19%)
		leucine-rich repeat	158..170	CDD:275378
		GPS	3106..3155	CDD:197639	13/53 (25%)
		PLAT	3213..3326	CDD:320707	28/130 (22%)
		PKD_channel	3802..4155	CDD:332708
		Atrophin-1	4496..>4606	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11108
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010