DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment osp and ARHGAP25

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	XP_016860912.1	Gene:	ARHGAP25 / 9938	HGNCID:	28951	Length:	650	Species:	Homo sapiens

Alignment Length:	704	Identity:	155/704 - (22%)
Similarity:	265/704 - (37%)	Gaps:	172/704 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 KKGWLMKQDNRTCEWSKHWFTLSGAALFYYRDPLCEERGVLDGVLDVNSLT--SVIPEPAASKQH 571
            |.|||.||.:....|.:.:|.|....|:||:|   ||.....|.:.:...|  .:...|..:.:.
Human    53 KMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKD---EEDTKPQGCMYLPGCTIKEIATNPEEAGKF 114

  Fly   572 AFQL--TTWDKQRL-----VLASLSPSSRNSWLAVLRSAAGLP-------QLDTPPKQTDIEQDF 622
            .|::  .:||:.|:     ||.:.|.:....|:..||..||.|       :||   :....||.|
Human   115 VFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGAVFGQRLD---ETVAYEQKF 176

  Fly   623 IKAQLQQPSSSPVTPGTPAGPHFSSDEEYRTAS---EGGRRDSLDWGSPLSPSPPVLRSCLRNRS 684
                               |||.......:.|.   |.||.:.   |....|....|...||:..
Human   177 -------------------GPHLVPILVEKCAEFILEHGRNEE---GIFRLPGQDNLVKQLRDAF 219

  Fly   685 LASLHKRSRSSPPSSRRSTVDSVAS------DELPLLVVPEEM--------QPTESRELKQQCET 735
            .|.      ..|...|.:.|.:|||      .:||..|||...        |.|.:.|.|.|.|.
Human   220 DAG------ERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQEL 278

  Fly   736 LRAEASLREARMSELLATLQRTEQQLTARLQEQQQQLNSELTQAKQSASDLMHNLGMQLTESQCQ 800
            ::..:.|.....| ||:.:.|...::         |||..:.  |.|..:|...:|:.|..|:.:
Human   279 MKQLSILPRDNYS-LLSYICRFLHEI---------QLNCAVN--KMSVDNLATVIGVNLIRSKVE 331

  Fly   801 --------IKQLEDRLAQGIEENEGLYKRLRELQ---------------AQDHSGGAALSNLQRH 842
                    ..|::..:...|.::|.|:.:.:::.               |:...|..|..:|
Human   332 DPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQKNDPKKAPVARSSVGWDATEDL--- 393

  Fly   843 KIKRMDSLSDLTTISDIDPYCLQRDSLAEEYNELRSRFEKAVN-EIRAMKRELKQSQNQYDALEL 906
            :|.|.||.|.:|:.||......|:.|.|...:..:...||..: ::::.||.......:......
Human   394 RISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPREKPGDWKMQSRKRTQTLPNRKCFLTSA 458

  Fly   907 AQAALQQKLERRQHEDGAQLQLMAARIQDLTLKYSSSERQVRALKQKLAKSERRRSLSLKGKEQL 971
            .|.|...|:|..::|..:                .|||.:        |....||::|    :.|
Human   459 FQGANSSKMEIFKNEFWS----------------PSSEAK--------AGEGHRRTMS----QDL 495

  Fly   972 ELKLSELQR----ETVERKEGTPPESSSSESSSQSPLNAHLLQRLHSLEHVLLGSKERLEQSLTQ 1032
            . :||:.||    :.|....|:|.|.:|:.||.........|...:|  ....|.|...|:.:..
Human   496 R-QLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNS--ETGPGKKNSGEEEIDS 557

  Fly  1033 LQQIRAGQRTRRSVSPMNDR-KDGLRQLERALAET---CVMVSEQMELTCLQDSCHKCCDLRQRV 1093
            ||  |..|..|:.:...... ::.::.||:...:.   .|.::|::|                :.
Human   558 LQ--RMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELE----------------KE 604

  Fly  1094 EKLSALQQQTETDLQRSEQLLEQRETDLAQALEKCASQEQEQELLLQQRQELSE 1147
            :|.||..:.:..:::||.:.:|:|.    :|||     |:.:|.:...::..:|
Human   605 KKKSAALEISLRNMERSREDVEKRN----KALE-----EEVKEFVKSMKEPKTE 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942
		PH	85..185	CDD:278594
		PH_M-RIP	509..613	CDD:270094	33/119 (28%)
		PH	509..603	CDD:278594	28/102 (27%)
		SbcC	726..1353	CDD:223496	93/454 (20%)
ARHGAP25	XP_016860912.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910