DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment osp and CYTH2

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	XP_006723535.1	Gene:	CYTH2 / 9266	HGNCID:	9502	Length:	421	Species:	Homo sapiens

Alignment Length:	360	Identity:	72/360 - (20%)
Similarity:	135/360 - (37%)	Gaps:	53/360 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 TSSQSAGNLLSSLDLGPSSTKTAGSPLTTTQSALAD-----DEEDDGVETGEDVDEDEEDETSVP 296
            :.:|....|....||.|.......:.....|..|.:     :|..:.:...|.::.:|..:|.
Human    19 SENQGLSPLPKPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTL-- 81

  Fly   297 RKSKTVSMGGQDEN-NRNAGNE--ITNRVSQPTTCLLIEDIRRDEKTIKDIANTITNLSQQQNKR 358
            ::::.::||.:..| :...|.:  :.|.:.|.|.    |:|.|.....:.:..|.......:.:.
Human    82 QRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTP----EEIARFLYKGEGLNKTAIGDYLGEREE 142

  Fly   359 WSTAVNNALNNQHHFGHHSQYQVTSRDETDFQMSSNSSSTKSQNPASERPKSL--PLASNSTPAI 421
            .:.||.:|..:.|.|...:..|...:....|::...:........|..:...|  |....||.
Human   143 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTD-- 205

  Fly   422 VSAIVKKIPTVMEQGDKTKPTARLQLHLKSPKHYQHERGDPDGGCNLDELCVNYMAKTDELRSVG 486
             :..|.....:|.......|..|.:..|:  :.....||..:||...:||..|..   |.:|:
Human   206 -TCYVLSFAVIMLNTSLHNPNVRDKPGLE--RFVAMNRGINEGGDLPEELLRNLY---DSIRN-- 262

  Fly   487 KANSKSSSGQGKP-PVKEESLN---------AKKGWLMKQDNRTCEWSKHWFTLSGAALFYYRDP 541
                       :| .:.|:..|         .::|||:|...|...|.:.||.|:...|:|:...
Human   263 -----------EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYT 316

  Fly   542 LCEE-RGVLDGVLDVNSLTSVIPEPAASKQHAFQL 575
            ..:| ||::.  |:..|:..| .:|  .|.:.|:|
Human   317 TDKEPRGIIP--LENLSIREV-DDP--RKPNCFEL 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942
		PH	85..185	CDD:278594
		PH_M-RIP	509..613	CDD:270094	21/68 (31%)
		PH	509..603	CDD:278594	21/68 (31%)
		SbcC	726..1353	CDD:223496
CYTH2	XP_006723535.1	Sec7	83..265	CDD:396096	37/206 (18%)
CYTH2	XP_006723535.1	PH_GRP1-like	280..399	CDD:269954	21/72 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910