DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and ARHGAP24

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	NP_001020787.2	Gene:	ARHGAP24 / 83478	HGNCID:	25361	Length:	748	Species:	Homo sapiens

Alignment Length:	816	Identity:	154/816 - (18%)
Similarity:	283/816 - (34%)	Gaps:	186/816 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 GQGKPPVKEESLNA-KKGWLMKQDNRTCEWSKHWFTLSGAALFYYRD-----PL----------- 542
            |||:.       || |.|||.||......|...||.|.|..|:|::|     ||
Human    14 GQGRQ-------NAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVS 71

  Fly   543 ---CEERGVLDGVLDVNSLTSVIPEPAASKQHAFQLTTWDKQRLVLASLSPSSRNSWLAVLRSAA 604
               |.|..      ....|..|:|             ..|:.|:.      ::..|:|.:..:
Human    72 EHPCNEEN------PGKFLFEVVP-------------GGDRDRMT------ANHESYLLMAST-- 109

  Fly   605 GLPQLDTPPKQTDIEQDFIKAQLQQPSSSPVTPGTPAGPHFSSDEEYRTASEGGRRDSLDWGSPL 669
                      |.|:| |::|      |...|..|...|..|....|.....|  :|    :|:.|
Human   110 ----------QNDME-DWVK------SIRRVIWGPFGGGIFGQKLEDTVRYE--KR----YGNRL 151

  Fly   670 SPSPPVLRSC---LRNRSL-----------ASLHKRSRSS------PPSSRRSTVDSVAS-DELP 713
            :|.  ::..|   :|.|.|           |:|.|..:.:      |.....:.|.:||| .:|.
Human   152 APM--LVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLY 214

  Fly   714 LLVVPEEMQPTESRELKQQCETL---RAEASLRE-ARMSELLATLQRTEQQLTARLQEQQQQLNS 774
            |..:||.:.|....|....|..|   ..||.::| |:..:.|..:.....:...|..::.|..:.
Human   215 LRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSG 279

  Fly   775 ELTQAKQSASDLMHNLG-----------MQLTESQCQIKQLEDRLAQGIEENEGLYKRLRELQAQ 828
               ..|.|..:|....|           :.:.|....::||   ::..|.:::.|:.:..|||::
Human   280 ---VNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQL---MSVMISKHDCLFPKDAELQSK 338

  Fly   829 DHSGGAALSNLQRH-KIKRMDSLSDLTTISDIDPYCLQRDSLAEEYNELRSRFEKAVNEIRAMKR 892
            ...|.:..:.:|:. .:.::.:..:..|.......|....|.:.:.:.:.:....|::..:.
Human   339 PQDGVSNNNEIQKKATMGQLQNKENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKT--- 400

  Fly   893 ELKQSQNQYDALELAQAALQQKLERRQHEDGAQLQLMAARIQDLTLKYSSSERQVRALKQKLAKS 957
              ...:|....|:::::......:......|:.:....:        :|||.      .:.|.|:
Human   401 --NSPKNSVHKLDVSRSPPLMVKKNPAFNKGSGIVTNGS--------FSSSN------AEGLEKT 449

  Fly   958 ERRRSLSLKGKEQLELKLSELQRETVERKEGTPPESSSSESSSQSPLNAHLLQRLHSLEHVLLGS 1022
            :...:.||:.:....||:|..:..|...:.||......:..:..:|.|...:..|.: .:|.|..
Human   450 QTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMGILNSDTLGNPTNVRNMSWLPN-GYVTLRD 513

  Fly  1023 KERLEQS--LTQLQQIRAGQRTRRSVSPMNDRKDGLRQLERALAETCVMVSEQMELTCLQDSCHK 1085
            .::.||:  |.|..::.......:..|.||  .|..:.::.|...|.   |.::.|....:||..
Human   514 NKQKEQAGELGQHNRLSTYDNVHQQFSMMN--LDDKQSIDSATWSTS---SCEISLPENSNSCRS 573

  Fly  1086 CCDLRQRVEKLS------ALQQQTETDLQRS---EQLLEQRETDLAQALEKCASQEQE------- 1134
            ........:...      .|....:.||...   |...:.|......:....:|...|
Human   574 STTTCPEQDFFGGNFEDPVLDGPPQDDLSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSS 638

  Fly  1135 ------QELLLQQRQELSEELGRQQERCRRLEKRLELLEREHGKQLECLREVYHTEHANAADEQS 1193
                  ..|:...:||::::....:.|.:.||:|...||               ||..:..||..
Human   639 SNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLE---------------TEMMSLHDELD 688

  Fly  1194 FRKRYQTEIEQLRTLCEKGLSAMETSHKRLTMDLEQ 1229
            ..::..|.||......|:.....|..:..|..::||
Human   689 QERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQ 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942
		PH	85..185	CDD:278594
		PH_M-RIP	509..613	CDD:270094	25/122 (20%)
		PH	509..603	CDD:278594	25/112 (22%)
		SbcC	726..1353	CDD:223496	91/544 (17%)
ARHGAP24	NP_001020787.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		3/12 (25%)
		PH_RhoGap24	18..131	CDD:241530	35/163 (21%)
		PH	21..124	CDD:278594	31/146 (21%)
		RhoGAP_ARHGAP22_24_25	131..329	CDD:239855	42/211 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..476		18/140 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..641		7/58 (12%)
		ATG16	<609..>723	CDD:285778	22/128 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910