DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment osp and triobpb

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	NP_001314738.1	Gene:	triobpb / 790927	ZFINID:	ZDB-GENE-061215-80	Length:	532	Species:	Danio rerio

Alignment Length:	743	Identity:	152/743 - (20%)
Similarity:	260/743 - (34%)	Gaps:	249/743 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 LNAKKGWLMKQDNRTCEWSKHWFTLSGAALFYYRDPLCEERGVLDGVLDVNSLTSVIPEPAASKQ 570
            ||.||||:.|.| .:.||.||||.|:.|.|.||||...|||..:||.:|:.:...| .|....|.
Zfish     6 LNFKKGWMSKLD-ESGEWRKHWFVLTDAGLKYYRDSAAEERDDVDGEIDLKACVKV-SEFEVEKN 68

  Fly   571 HAFQLTTWDKQRLVLASLSPSSRNSWLAVLRSAAGLPQLDTPPKQTDIEQDFIKAQLQQPSSSPV 635
            :.||:.|.|.. ..|::::...|.:|:.:|:...      .|....|:      .||...||...
Zfish    69 YGFQIQTRDAV-FTLSAMTAGIRRNWIEILKKNV------RPGSSPDL------TQLANCSSDKE 120

  Fly   636 TPGTPAGPHFSSDEEYRTASEGGRRDSLDWG--SPLSPSPPVLRSCLRNRSLASL--HKRSRSSP 696
            ....|:.....|..|..:|......:..|:.  ||::..|..|.:..|......:  |.:.:.:.
Zfish   121 NTRHPSSLRLRSQSEASSAIINSAHNKFDYVELSPIATPPTPLSTNQRESGEGQVKEHSQWQETR 185

  Fly   697 PS-----------SRRSTVDSVASDELPLLVVPEEMQPTESRELKQQCETLRAE---ASLREARM 747
            ||           ||:.|                 .|.:|.:.::::.|...||   ..|:|.|.
Zfish   186 PSDDAHNQWEAVLSRKGT-----------------SQLSEQKRIEEEIERKWAEFERLPLKETRS 233

  Fly   748 SELLATLQRTEQQLTARLQEQQQQLNSELTQAKQSASDLMHNLGMQL--TESQCQ--IKQLEDRL 808
            ...:.:..:..::..|.|::|..:|.:...|.::.:     ..|.|.  .||:|.  ::|:|.|.
Zfish   234 HPAMRSSNQALEREVASLRQQLAELGAGQGQGREGS-----GAGHQCCGAESRCSDVLQQMERRH 293

  Fly   809 AQGIEENEGLYKRLRELQAQDHSGGAALSNLQRH--KIKRMDSLSDLTTISDIDPYCLQRDSLAE 871
            ...:||.|                       |||  :|..:::               |||:|.:
Zfish   294 RAVMEEQE-----------------------QRHAQQISALEA---------------QRDTLLQ 320

  Fly   872 EYNELRSRFEKAVNEIRAMKRELKQSQNQYDALELAQAALQQKLERRQHEDGAQLQLMAARIQDL 936
            |.....:...:|:.  :|.:.||:    :...|:..:|.....|.::|.::...|:
Zfish   321 EEAHATATVMEALQ--KAHREELE----KITQLKQTRALDSHTLNKQQQDEVCSLR--------- 370

  Fly   937 TLKYSSSERQVRALKQKLAKS--ERRRSLSLKGKEQLELKLSELQRETVERKEGTPPESSSSESS 999
                    |:::||.::.::.  |.:|:..|:.....:::|.:.|.|.:.|.:
Zfish   371 --------RELQALSERYSQQCVELKRAQQLRDDSDTQIRLMDTQMEQLRRDK------------ 415

  Fly  1000 SQSPLNAHLLQRLHSLEHVLLGSKERLEQSLTQLQQIRAGQRTRRSVSPMNDRKDGLRQLERALA 1064
                      |.|.:          ||...:..::.:..||.:.                    |
Zfish   416 ----------QDLQA----------RLTDEMKLIRSLATGQGSS--------------------A 440

  Fly  1065 ETCVMVSEQMELTCLQDSCHK-CCDLRQRVEKLSALQQQTETDLQRSEQLLEQRETDLAQALEKC 1128
            ||              |..|: ||::                     :.||..||.:|
Zfish   441 ET--------------DDTHRSCCEM---------------------QVLLRVRENEL------- 463

  Fly  1129 ASQEQEQELLLQQRQELSEELGRQQERCRRLEKRLELLEREHGKQLECLREVYHTEHANAADEQS 1193
                          |.|..||       ..|..:|..|..|  |...|.|      ::...:|.|
Zfish   464 --------------QYLHREL-------NSLRNQLHFLTTE--KSSVCAR------YSEVCEELS 499

  Fly  1194 FRK-RYQTEIEQLRTLCEKGLSAMETSH 1220
            ..| |.:.|.|.||......|:|:...|
Zfish   500 VMKSRSERETETLREHLRLALNALSEGH 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942
		PH	85..185	CDD:278594
		PH_M-RIP	509..613	CDD:270094	36/103 (35%)
		PH	509..603	CDD:278594	36/93 (39%)
		SbcC	726..1353	CDD:223496	90/508 (18%)
triobpb	NP_001314738.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577696
Domainoid	1	1.000	69	1.000	Domainoid score	I9570
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4051
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002350
OrthoInspector	1	1.000	-	-		otm25629
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR17271
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.080