DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment osp and PLEKHA2

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	NP_067636.1	Gene:	PLEKHA2 / 59339	HGNCID:	14336	Length:	425	Species:	Homo sapiens

Alignment Length:	333	Identity:	67/333 - (20%)
Similarity:	118/333 - (35%)	Gaps:	99/333 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 QPTT--CLLIEDIRR-------DEKTIKDIANTITNLSQQQNKRWSTAVNNALNNQHHFGHHSQY 379
            :|.|  |.:|..:.:       |:|.:||               |..|:|.|            .
Human    75 KPKTPFCFVINALSQRYFLQANDQKDMKD---------------WVEALNQA------------S 112

  Fly   380 QVTSRDETDFQMSSNSSSTKSQNPASERPKSLPLASNSTPAIVSAIVKKIPTVMEQGD---KTKP 441
            ::|........|::....:.:..||.|:.   |..:..| .|:..:|...|.....||   .::|
Human   113 KITVPKGGGLPMTTEVLKSLAAPPALEKK---PQVAYKT-EIIGGVVVHTPISQNGGDGQEGSEP 173

  Fly   442 TARLQLHLKSPKHYQHERGDPDGGCNLDELCVNYMAKTDELRSVGKANSKSSSGQGKPPVKEESL 506
            .:...|. :|..:.      |..||                        ::|:|   ||:
Human   174 GSHTILR-RSQSYI------PTSGC------------------------RASTG---PPL----- 199

  Fly   507 NAKKGWLMKQDNRTCEWSKHWFTLSGAALFYYRDPLCEE-----RGV-LDGVLDVNSLTSVIPEP 565
             .|.|:.:||.|....|.:.:|.|....:.|::   ||:     |.: |..||..:... |....
Human   200 -IKSGYCVKQGNVRKSWKRRFFALDDFTICYFK---CEQDREPLRTIFLKDVLKTHECL-VKSGD 259

  Fly   566 AASKQHAFQLTTWDKQRLVLASLSPSSRNSWLAVLRSAAGLPQLDTPPKQTDIEQDFIKAQLQQP 630
            ...:.:.|::.|..:...|.|. ||...:||:..:  .|.:..|...|::|...:..   .|.:|
Human   260 LLMRDNLFEIITSSRTFYVQAD-SPEDMHSWIKEI--GAAVQALKCHPRETSFSRSI---SLTRP 318

  Fly   631 SSSPVTPG 638
            .||.::.|
Human   319 GSSSLSSG 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942
		PH	85..185	CDD:278594
		PH_M-RIP	509..613	CDD:270094	26/109 (24%)
		PH	509..603	CDD:278594	24/99 (24%)
		SbcC	726..1353	CDD:223496
PLEKHA2	NP_067636.1	PH1_TAPP1_2	1..119	CDD:270089	13/70 (19%)
		PH	10..113	CDD:278594	12/64 (19%)
		PH2_TAPP1_2	192..307	CDD:270090	31/130 (24%)
		PH	199..297	CDD:278594	25/110 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..332		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910