DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and RASGRF1

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	NP_002882.3	Gene:	RASGRF1 / 5923	HGNCID:	9875	Length:	1273	Species:	Homo sapiens

Alignment Length:	1343	Identity:	227/1343 - (16%)
Similarity:	387/1343 - (28%)	Gaps:	563/1343 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 LNNQHH----FGHHSQYQVTSRDETDFQMSSNSSSTKSQNPASERPKSLPLASNSTPAIV-SAIV 426
            |..||:    |.|.:|..:..|             |:......|...::..||..|.|.. .|::
Human    89 LEKQHYFTVNFSHENQKALELR-------------TEDAKDCDEWVAAIAHASYRTLATEHEALM 140

  Fly   427 KKIPTVMEQGDKTKPTARLQLHLKSPKHYQHERGDPDGGCNLDELCVNYMAKTDELRSVGKANSK 491
            :|...:::..:..|..|:           |..:...||...::.|       ..|:.|:.|.|.:
Human   141 QKYLHLLQIVETEKTVAK-----------QLRQQIEDGEIEIERL-------KAEITSLLKDNER 187

  Fly   492 SSSGQGKPPVKEESLNAKK---------GWLMKQDNRTCEWSKHWFTLSGAALFYYRDPLCEERG 547
            ..|.|...|..|:| :.||         |||.:         :.|.|:   ...|.|.|..
Human   188 IQSTQTVAPNDEDS-DIKKIKKVQSFLRGWLCR---------RKWKTI---IQDYIRSPHA---- 235

  Fly   548 VLDGVLDVNSLTSVIPEPAASKQHAFQLTTWDKQRLVLASLSPSSRNSWLAVLRSAAGLPQLDTP 612
              |.:...|.:...:.|..|.         :.:|..:|.       |::|..||.||...:   |
Human   236 --DSMRKRNQVVFSMLEAEAE---------YVQQLHILV-------NNFLRPLRMAASSKK---P 279

  Fly   613 PKQTD--------------IEQDFIKAQLQQPSSSP----------VTPGTPAGPHFSSDEEYRT 653
            |...|              :.|.|.:....:.||.|          :.|.......|..:.:|
Human   280 PITHDDVSSIFLNSETIMFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQY-- 342

  Fly   654 ASEGGRRDSLDWGSPLSPSPPVLRSCLRNRSLASLHKRSRSSPPSSRRSTVDSVASDELPLLVVP 718
                              |..:|..|.:||....|.|...:.|....| |:::..:  .|:..:|
Human   343 ------------------SLQILAHCKQNRDFDKLLKHYEAKPDCEER-TLETFLT--YPMFQIP 386

  Fly   719 --------------------------------------EEMQPTES--------RELKQQCE--- 734
                                                  :|:..||:        |.:.:.||
Human   387 RYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMIIEGCEILL 451

  Fly   735 ----TLRAEASLREARMSE----------LLATLQRTEQQ------------------------- 760
                |...:.||.:..|||          .|:..:..|:|
Human   452 DTSQTFVRQGSLIQVPMSEKGKITRGRLGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNG 516

  Fly   761 ----LTARLQEQQQQLNSELTQAKQSASDLMH---NLGMQLTES------------------QCQ 800
                :...|.|:.:....|   ||.|..|:.|   .:|::..:|                  ...
Human   517 VISLIDCTLLEEPESTEEE---AKGSGQDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSD 578

  Fly   801 IKQLEDR------LAQGIEENE-----GLYKRLRELQAQDHSGGAALSNLQRHKIKRMDSLSDLT 854
            |.|..|.      :....|||.     .:.||.||        |...:.:.|
Human   579 ISQCVDNIRCNGLMMNAFEENSKVTVPQMIKRTRE--------GTREAEMSR------------- 622

  Fly   855 TISDIDPYCLQRDSLAEEYNELRSRFEKAVNEIRAMKRELKQSQNQYDALELAQAALQQKLERRQ 919
              ||...||          :::..||.|.:|..:              .|::..|::::.|||..
Human   623 --SDASLYC----------DDVDIRFSKTMNSCK--------------VLQIRYASVERLLERLT 661

  Fly   920 --------------HEDGA----------------------------QLQLMAARIQDLTLKYSS 942
                          |....                            .|:|:.|..|:..|.|..
Human   662 DLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNNKLLYGE 726

  Fly   943 SERQVRALKQ----------KLAKSERRRSLSLK------------------------------- 966
            ..:..||.::          |.:...|||.|||.
Human   727 PPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSNGYTSMYSAMSP 791

  Fly   967 --------------------------------------GKEQLELKLSEL-----------QRET 982
                                                  .|:..|:.:.|.           ..||
Human   792 FSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDIDQNQSDDGDTET 856

  Fly   983 VERKEGTPPESSSSESSSQSPLNAHLLQRLHSLEHVLLGSKERLEQSLTQLQQIRA--------- 1038
            ...|..|.|:|..:::||:.||.::       ...|::.|...|:.:.:.|....|
Human   857 SPTKSPTTPKSVKNKNSSEFPLFSY-------NNGVVMTSCRELDNNRSALSAASAFAIATAGAN 914

  Fly  1039 -GQRTRRSVSPMN--------DRKDGLRQ--LERALAETCVMVSEQMELTCLQDSCHKCCDLRQR 1092
             |...:.....|:        |:::|.::  :.||.....:.|                  ||..
Human   915 EGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNV------------------LRHW 961

  Fly  1093 VEKLSALQQQTETDLQRSEQLLEQRETDLAQALEKCASQEQEQELLLQQRQELSEELGRQQERCR 1157
            |.|.|   |..||:        ::.:..:...||:..   .:.|||.|:|:..:..:
Human   962 VSKHS---QDFETN--------DELKCKVIGFLEEVM---HDPELLTQERKAAANII-------- 1004

  Fly  1158 RLEKRLELLEREHGKQLECLREVYHTEHANAADEQSFRKRYQTEIEQLRTLCE------------ 1210
                 ..|.:.:.|.....|.|:  |:.|.....:.|......||.:..||.:
Human  1005 -----RTLTQEDPGDNQITLEEI--TQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEF 1062

  Fly  1211 --KGLSAMETSHKRLTMDLEQKHKMEIERLLAEKETALAEETQATLAAL-------DAMRKAHQS 1266
              :|...:|.:.:...:....||..:|..|:| .|....|:..|.::|:       |..|..|..
Human  1063 FGQGWMKLEKNERTPYIMKTTKHFNDISNLIA-SEIIRNEDINARVSAIEKWVAVADICRCLHNY 1126

  Fly  1267 EVQREVA---------RFKQEFLR----------QVQRGEQMRGDGAKLKE----------EDLG 1302
            ....|:.         |.|:.:|:          ::|:.....|....|:|          ..||
Human  1127 NAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLG 1191

  Fly  1303 ELRMEILAFSEKYSIKCVENAALE-EKLHMANSKLRHFQQMQQ 1344
             :.:..|||.|:.:....|:..:. .|:.|.:..:|..:|.||
Human  1192 -MYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQ 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942
		PH	85..185	CDD:278594
		PH_M-RIP	509..613	CDD:270094	22/112 (20%)
		PH	509..603	CDD:278594	20/102 (20%)
		SbcC	726..1353	CDD:223496	149/908 (16%)
RASGRF1	NP_002882.3	PH	489..583	CDD:278594	14/96 (15%)
		RasGEF_N	647..>695	CDD:279012	5/47 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..754		4/29 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..874		9/64 (14%)
		REM	<938..1007	CDD:295342	19/113 (17%)
		RasGEF	1034..1270	CDD:214539	40/202 (20%)
		PH_RasGRF1_2	19..154	CDD:270081	15/77 (19%)
		PH	24..129	CDD:278594	10/52 (19%)
		RhoGEF	244..425	CDD:214619	33/222 (15%)
		PH-like	431..582	CDD:302622	24/153 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910