DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and PLEKHH1

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	XP_011535311.1	Gene:	PLEKHH1 / 57475	HGNCID:	17733	Length:	1392	Species:	Homo sapiens

Alignment Length:	1242	Identity:	242/1242 - (19%)
Similarity:	386/1242 - (31%)	Gaps:	449/1242 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 AITAPERVTFVKGTSSEESQWWLNILAAFPKSKGRHKRSATLPGGQVVGSLRPTSNG-DLTLSTK 223
            |.|..|:...:|.        |:.:..|..:.:.:|.:|......:.||||:..... .:..|.|
Human   121 AKTVQEKAAKIKE--------WVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQIAPSRK 177

  Fly   224 -LGNRHSSYHKDTLTS------------SQSAGNLLSSLDLGPS--------STKTAGSPLTTTQ 267
             |...:.:..:|::.|            ||:.|  |.:..|.||        |...|.|||
Human   178 LLVPPYGAAEQDSVPSEPGIQPMGQDSGSQAQG--LKAAVLAPSPGALQSKDSVSEAASPL---- 236

  Fly   268 SALADDEEDDGVETGEDVD----EDEEDETSVPR---------KSKTVSMG-GQDENNRN--AGN 316
                :|.....|.:||.|:    :......|.|.         :..:.|.| |.....|.  .|.
Human   237 ----EDSSSSTVHSGETVEAKPLQPHLGRESPPHQPCMKLLTFRCSSASWGEGLVTAQRGMLPGT 297

  Fly   317 EITNRVSQPTTCLLIEDIRRDEKTIKDIANTITNLSQQQNKRWSTAVNNALNNQHHFGHHSQYQV 381
            :.:.|...|.:.|.:..:|. ..|.:|        |.|..||                ||||.||
Human   298 KTSAREGGPGSSLTLPKVRA-PGTPRD--------SIQLAKR----------------HHSQPQV 337

  Fly   382 -------------------------------TSRDETDFQMSSNSSSTKSQNPASERPKSL---- 411
                                           .||:|.: :|.........:|...|.||:|
Human   338 GHGHFGRVVNIETEAFSALHPSGLPELESRARSREEPE-KMEMEEPPPAGKNEERESPKALGAEL 401

  Fly   412 ------------PL-------------------------------ASNSTPAIV-----SAIVKK 428
                        ||                               .::|.||:|     |.:|.|
Human   402 EEVELGNKPPTPPLHQFSSWESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYK 466

  Fly   429 IPTV------------------MEQG----DKTKPTARLQLH-----------LKSPKHYQH--- 457
            ..||                  |::.    |.....|..::.           |.||:..:.
Human   467 NVTVPVYTALKGRATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVS 531

  Fly   458 -----ERGD---PDGGCNLDELCVNYMAKTDELRSVGKANSKSSSGQGKPPVKEESLNAKKGWLM 514
                 ..||   |...|:||.   :|.....:|:   :.:|.|:.|.|   :..|||. |.|:|:
Human   532 MSSLSSEGDYAIPPDACSLDS---DYSEPEHKLQ---RTSSYSTDGLG---LGGESLE-KSGYLL 586

  Fly   515 KQDNRTCEWSKHWFTLSGAALFYYRDPLCEERGVL---DGVLDVNSLTSVIPEPAASKQHAFQLT 576
            |..::...|.:.||.|....:.||:.|    ..|:   .|.:|:||...::   .......|||.
Human   587 KMGSQVKTWKRRWFVLRQGQIMYYKSP----SDVIRKPQGQVDLNSRCQIV---RGEGSQTFQLI 644

  Fly   577 TWDKQRLVLASLSPSSRNSWLAVLRS-----AAGLPQL---DTPPKQTDIEQDFIKAQLQ--QPS 631
            : :|:...|.:.|||....|:.||:|     |.|.|.|   .|.|.        :|..|.  :..
Human   645 S-EKKTYYLTADSPSLLEEWIRVLQSLLKVQATGPPALLRGGTKPT--------VKGWLTKVKHG 700

  Fly   632 SSPVTPGTPAGP---HFSSDEEYRTASEGGRRDSLDWGSPLSPSPPV----LRSCLRNRSLASLH 689
            .|.|......|.   ::.|.|:....:...|...|       |.||:    :..|...|.|..|.
Human   701 HSKVVWCALVGKIFYYYRSHEDKLHGAYVFRERRL-------PHPPLALPFMEDCCPQRPLGCLP 758

  Fly   690 KRSRSSPPSSRRSTVDS---------VASDELPLLVVPEEMQPTESR-ELKQQCETLRAEASLRE 744
            .|........|....|.         :.|....|::.|.|..||... ..|.:.:|.....::..
Human   759 VRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLIGTKHEKDTWLYHLTVAA 823

  Fly   745 ARMSELLATLQRTEQQLTARLQEQQQQLNSELTQAKQSASDLMHNLGMQLTESQCQIKQLEDRLA 809
            ...|..:.|   ..:||..:|.:.:...:|.|.:         |.:       .|..|
Human   824 GGSSAKVGT---AYEQLIGKLMDGEGDPDSPLWR---------HPM-------LCYSK------- 862

  Fly   810 QGIEENEGLYKRLRELQAQDHSGGAALSNLQRHKIKRMDSLSDLTTI----SDIDPY-------- 862
                  :|||..|..|.::         .||...:|...|......:    :.:|.:
Human   863 ------DGLYASLTTLPSE---------ALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTAL 912

  Fly   863 --CLQRDSLAEE-YNELRSRFEKAVNEIRAMKRELKQSQNQYDALE----LAQAA---------- 910
              ||....|..| |.:|             ||:...:...:|..::    ||..|
Human   913 QVCLVHPELQSEIYCQL-------------MKQTSCRPPQKYSLMQCWQLLALCAPLFLPQHHFL 964

  Fly   911 --LQQKLERRQHED----GAQLQLMAARIQDLTLKYSSSERQVRALKQK----LAKSERRRSL-- 963
              ::|:|:|  |.|    ..|......|..:.||:  :.||:.|..:.:    |.::....||
Human   965 WYVKQQLQR--HADPRSETGQYATYCQRAVERTLR--TGEREARPSRMEVVSILLRNPFHHSLPF 1025

  Fly   964 --------------SLKGKEQLELKLSELQRETVERKEGTPPESSSSESSSQSPLNAHLLQRLHS 1014
                          ...|...::..|..|.:|...||    |..|.....:..|..       ..
Human  1026 SIPVHFTNGTYHVVGFDGSSTVDEFLQRLNQEIGMRK----PSHSGFALFTDDPSG-------RD 1079

  Fly  1015 LEHVLLGSKE------RLEQSLTQLQ--QIRAGQRT-----------RRSVSPMNDRKDGL--RQ 1058
            |||.|.||.:      :.||::.:|.  :...|.|.           |..|....||:..|  .|
Human  1080 LEHCLQGSVKICDAISKWEQAMKELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQ 1144

  Fly  1059 LERALAETCVMVSEQMELTCLQDSCHKCCDLRQRVEKLSALQQQTE--------------TDLQR 1109
            ..|.:......:::::.|                  :::||..|.|              |...:
Human  1145 TSREIVAGRFPINKELAL------------------EMAALMAQVEYGDLEKPALPGPGGTSPAK 1191

  Fly  1110 SEQLLEQ 1116
            ::.||:|
Human  1192 AQHLLQQ 1198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942	6/30 (20%)
		PH	85..185	CDD:278594	5/24 (21%)
		PH_M-RIP	509..613	CDD:270094	33/114 (29%)
		PH	509..603	CDD:278594	28/101 (28%)
		SbcC	726..1353	CDD:223496	85/482 (18%)
PLEKHH1	XP_011535311.1	flagell_FliJ	27..164	CDD:131526	11/50 (22%)
		FlgN	31..186	CDD:298847	15/72 (21%)
		PH	579..672	CDD:278594	29/101 (29%)
		PH1_PLEKHH1_PLEKHH2	581..676	CDD:241436	28/102 (27%)
		MyTH4	860..1014	CDD:214535	35/192 (18%)
		B41	1027..1258	CDD:214604	36/201 (18%)
		FERM_M	1130..1258	CDD:278785	15/87 (17%)
		FERM_C-lobe_PLEKHH1_PLEKHH2	1254..1356	CDD:241360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910