DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and AgaP_AGAP005285

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	XP_001688161.2	Gene:	AgaP_AGAP005285 / 5667264	VectorBaseID:	AGAP005285	Length:	3916	Species:	Anopheles gambiae

Alignment Length:	1802	Identity:	348/1802 - (19%)
Similarity:	587/1802 - (32%)	Gaps:	598/1802 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PTPTTTGAAGATTNARTADCRKFTPNIFNKSKCSHCFRQREEHSAAALEC------NRRTSSNLA 78
            |.|...|::.:.  .||:........:..|:...|..|.:.|:....||.      |....|:..
Mosquito  2197 PGPPPHGSSESI--GRTSSSGPILSPLREKNLSLHDARCQSEYLGTVLEGHSLDVENASVLSSAL 2259

  Fly    79 EPASRKVSKCGYLFVAPDWDFSNPLYRTKRWQRRWFVLYDDGELTYSVDDYPETIPQACVDMTKV 143
            :|..:  |.|   .:..|::.:|...||       ....::|.:.:||...|
Mosquito  2260 DPDQQ--SSC---TLRGDYERANQCNRT-------ITPIEEGGVAHSVVAEP------------- 2299

  Fly   144 LEVTSAVEVTGHPNSIAITAPERVTFVKGTSSEESQWWLNILAAFPKSK------GRHKR----- 197
                    :....||.             .|||.:.::.:.|.|...|:      .:|.|
Mosquito  2300 --------LHSRNNST-------------LSSEGAPYYYSDLQARAGSREDDRVAQQHSRQLSSE 2343

  Fly   198 -----SATL------------PGG---QVVGSL----RPTSN----GDLTLSTKLGNRHSSYHKD 234
                 :||:            |||   ...||:    .|.:|    .:|.|......:|:...:.
Mosquito  2344 RCGGPTATITQPGDTLNNQRDPGGLRKPTTGSIFHIHNPLNNTLKAANLLLHASATEKHADIDRK 2408

  Fly   235 TLTSSQSAG------NLLSSLDLGPSSTKT--AGSPLTTTQSALADDEEDDGVETGEDVDEDEED 291
            .:..|...|      .:.:||..|.|....  :||.|:...|                     :|
Mosquito  2409 NIYESDRIGQKDVNKTIAASLAAGGSRAVAGRSGSSLSMATS---------------------KD 2452

  Fly   292 ETSVPRKSKTVSMG-------GQDENNRNAGNEITNRVSQPTT-CLLIEDIRRDEKTIKDIANTI 348
            .::|..:..|.|:|       |.|....:|||      ..|.. |  ....|||...::.:.:|.
Mosquito  2453 GSAVNVRQSTGSLGGGYTGVVGGDGGAYSAGN------GDPAAGC--SSSSRRDSVQMQQMLDTS 2509

  Fly   349 -TNLSQ-----QQNKRWSTAVN-------NALNNQHHFG----------------HHSQYQVTSR 384
             .|:|.     :::..|...:.       .:::|..|.|                ...|.|...|
Mosquito  2510 GGNISSGDQLWEEDTLWRDNLRRVSHIHAKSMDNLDHLGTIRSPSSAALLVKTINQQQQQQQEQR 2574

  Fly   385 DETDFQM---SSNSSSTKSQNP-------------ASERPKSLPLA-------SNSTPAIVSAIV 426
            :..|.::   ..:::..:..||             .:|....||::       |.|..|:.:..:
Mosquito  2575 EMQDHRLRDAHQDAAHGEETNPKPIVKINRKDVTYVNEHLAHLPVSKAVFGEQSLSAAAVANKSI 2639

  Fly   427 KKIPTVMEQ-----GDKTKPTARLQLHLKSPKHYQHE-RGDPDGGCNLDELCVNYMAKTDE---- 481
            .:.|..:|:     ||......:|..::.|......: |.....|.:.|.:   |....||
Mosquito  2640 LRTPLAIEEGAGGNGDDDDVYVQLASNVSSSGTIVRDGRWSSSSGRDSDAV---YEVLRDEINRY 2701

  Fly   482 -----------LRSVGKANSKSSSG---------QGKPPVKEESLNAKKGWLMKQDNR---TCEW 523
                       |.|.|..||.:|:|         .......::.|:|..|.:..:.|.   ..|.
Mosquito  2702 DINRETIRQWDLMSSGLVNSSNSAGGSTSRSGGNNSSETYHQKPLSAANGGISGKPNAQQPAMES 2766

  Fly   524 SKHWFTL------SGAALFYYRDPLCEERGVLDGVLDVNSLTSVIPEPAASKQHAFQLTTWDKQR 582
            :....||      |.||..||.: .||:.   ..|:.|:||.|.......||:.  ..|..||..
Mosquito  2767 AGDAITLPSAGTRSLAAKQYYVE-ACEKP---HDVMSVSSLNSGKHSMEDSKRK--METLRDKYN 2825

  Fly   583 LVLASLSPSSRNSWLAVLRSAAGLPQ--LDTPPKQTDIEQDFIKAQLQQPSSSPVTPGT------ 639
            |. .|:|          :|:...||:  |...|..:|      .|.||..:....|||:
Mosquito  2826 LD-TSIS----------VRNVFNLPKVALTVKPDPSD------PAYLQAVAKGAGTPGSSYYEGM 2873

  Fly   640 ----PAGPHFSSDEEYRTASEGGRRDSLDWGSPLSPSPPVLRSCLRNRSLASLHKRSRSSPPSSR 700
                .|..:::||:..|                                           |..|.
Mosquito  2874 MMGAAAADYYASDKYIR-------------------------------------------PDISF 2895

  Fly   701 RSTVDSVASDELPLLVVPEEMQPTESRELKQQCETLRAEASLREARMSELLATLQRTEQQLTARL 765
            .||.|         |....::|..:...|:|..:....:.|         |||:| .:|||....
Mosquito  2896 ESTHD---------LYTQAQLQRAQELNLQQHYQLQNIDRS---------LATMQ-DQQQLPQDA 2941

  Fly   766 QEQ------------------------------------QQQLNSELTQAKQ---SASDLMHNLG 791
            ..|                                    .:..:||...||.   ||.||::...
Mosquito  2942 SPQSPMAGRPDGPAHWSATPTTAGGATGNEPGGYMNGRMNRDASSERLDAKPLDVSAGDLLNRTH 3006

  Fly   792 MQLTESQCQIKQLEDRLAQGIEENEGLYKRLRELQAQDHSGGAALSNLQR--HKIKRMDSLSDLT 854
            .:|.....|:::...:.|:.||:   ....:.|||           ||.|  ...::.|||:.|
Mosquito  3007 EELILLLIQLRRQNSQTARSIEQ---CCTNIHELQ-----------NLIRTAEGNRKADSLARL- 3056

  Fly   855 TISDIDPYCLQRDSLAEEYNELRSRFEK---AVNEIRAM-------------KRELKQSQN-QYD 902
                        |:|.::..||..::||   .:|.:..|             |::|:..:: ..|
Mosquito  3057 ------------DALKQQLTELEKQYEKEKPLINLVDNMVKLGSLYRGPVGGKKQLQSPESATLD 3109

  Fly   903 ALELAQAALQQKL---ERRQHE----DGAQLQLMAARIQDLTLKYSSSERQVRALKQKLAKSERR 960
            .||..|...:::|   |:||.:    :..:||   :::|.|        .|:..|.|:  :|...
Mosquito  3110 RLEFNQRMQERRLLQEEQRQWDRTSPNHVELQ---SKVQQL--------YQIDKLMQE--ESGTL 3161

  Fly   961 RSLSLKGKEQLELKLSELQRETVERKEGTPPESSSSESSSQSPLNAHLLQRLHSLEHVLLGSKE- 1024
            ::|. :.||.||..|:.|:...:.|:.|..|.:..:....|     |.|:|..:..|.||.:..
Mosquito  3162 QALQ-RDKENLEKALATLKTHVLNREGGNMPMAMDTARQQQ-----HTLERELTRVHQLLAANSK 3220

  Fly  1025 ----------RLEQSLTQLQQIRAGQRTRRSVSPMNDRKDGLRQLERALAETCVMVSEQMELTCL 1079
                      ||||.|..|:|.....|..||:..:.|....:.......:.|.|:.||......|
Mosquito  3221 KLEKTVSTNARLEQELLVLRQKLQASREHRSMHSVFDSASPMDNQYMPGSVTAVLESELKRAKLL 3285

  Fly  1080 QDSCHKCCDLRQRVEKLSALQQQTETDLQRSEQLLEQRETDLAQALEKCASQEQEQELLLQQRQE 1144
            .....     |||.|...|::|.|........|::::.:.|..|.:.....|:::|:   ||:|:
Mosquito  3286 VGDMQ-----RQRQELGQAVRQLTSYSDNHEAQMMDRLQADEQQHMAHSQEQQRDQQ---QQQQQ 3342

  Fly  1145 LSEELGRQQERCRRLEKRLELLEREHGKQLECLREVYHTEHANAA-------DE-QSF---RKRY 1198
            .:....::......:|..|:.|.   ||:........|...:::|       || ||.   ..|.
Mosquito  3343 SASAKHKRSYSSSWVETDLDSLA---GKESSVSSASNHRALSSSASSVLTIDDEMQSLFLPSSRA 3404

  Fly  1199 QTEIEQLRTLCE----------KGLSAMETSHKRLTMDLEQKHKMEIERLLAEKETALAEETQAT 1253
            :..||...:|.:          .|...|..|..:..:...:..|.|.||.:.:|     |:....
Mosquito  3405 KEPIEGAESLDDLYSAGGPLYNYGAGGMLNSADKQEIKTVRIVKRESERRMRDK-----EKNDRN 3464

  Fly  1254 LA-ALDAMRKAHQSEVQREVARFKQEFLR--QVQRGEQ-----MRG------------DGAKLKE 1298
            || :||        :|..|.|:..:::.|  .:.||.:     ::|            ||.||
Mosquito  3465 LALSLD--------QVLEEEAQLMEDYQRSKSLPRGYETHELFVQGHESGSDAVAGSLDGNKL-- 3519

  Fly  1299 EDLGELRMEILAFS--EKYSIKCVENAALEEKLHMANSKLRHFQQMQQLELRNKQFRAHLASDDP 1361
              :.:....::|.:  ..|.:..::                     :|.:|....|...|.|...
Mosquito  3520 --MSDYYSSVVASTNGNSYPVSLID---------------------RQADLYTGNFDGGLQSKYL 3561

  Fly  1362 SNDVHFVQGLTS------------------------------------DAREDADCE-----DSE 1385
            |||...|.|:.|                                    .:...||.|     .||
Mosquito  3562 SNDGSRVSGVGSVSSYQSSYLGSVGSTGSTTGMSTSSLSGLKRKTESIQSLTHADAELDPVFQSE 3626

  Fly  1386 PAPQILGATATRTTATTTTTATATTTSAAPSETESNPD------SDRETADSSR----APPEKME 1440
            .|.||:...||....|....:..::.|.....|.|..|      ..|:.|..:|    .|.:|..
Mosquito  3627 AAKQIINEMATGGNMTVGENSGDSSGSGETKATSSMKDDQQYQQQQRQQAQQNRQRRAVPKDKRR 3691

  Fly  1441 QSLFVIPSHMLNSSLVPAANASDQSQRSQLYRDLDGPEDGYEPCYRP 1487
            .  ...|.|:...|:....:.:|.::.:..:|..|..:  .|...||
Mosquito  3692 H--HTAPHHVNAKSIELMHSENDMNKNNVNWRARDDVD--LEVTIRP 3734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942	26/148 (18%)
		PH	85..185	CDD:278594	15/99 (15%)
		PH_M-RIP	509..613	CDD:270094	29/114 (25%)
		PH	509..603	CDD:278594	26/102 (25%)
		SbcC	726..1353	CDD:223496	151/745 (20%)
AgaP_AGAP005285	XP_001688161.2	PH_PEPP1_2_3	510..612	CDD:270068
		PH	520..612	CDD:278594
		PspA	3097..3323	CDD:224755	60/249 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910