DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and si:ch73-103b11.2

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	XP_005162957.1	Gene:	si:ch73-103b11.2 / 562530	ZFINID:	ZDB-GENE-080917-14	Length:	2480	Species:	Danio rerio

Alignment Length:	1861	Identity:	407/1861 - (21%)
Similarity:	696/1861 - (37%)	Gaps:	589/1861 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 TTNARTADCRKFTPNIFNKSKCSHCFRQREEHSAAALECNRRTSSNLAEPASRKVSKCGYLFVAP 95
            :|:|:...||||..||||||||.:||:.|:.|..:..:..:      |:|...     |:|.:||
Zfish     4 STSAKDNACRKFQANIFNKSKCQNCFKARDAHLLSDEDFTQ------AKPIYG-----GWLLLAP 57

  Fly    96 D-WDFSNPLYRTKRWQRRWFVLYDDGELTYSVDDYPETIPQACVDMTKVLEVTSAVEVTGHPNSI 159
            : .:|.|||:|:::||||:|:||:.|.|.|::||...|:||..:::.:.::|......||..:|:
Zfish    58 EGTNFDNPLHRSRKWQRRFFLLYEHGLLRYALDDMASTLPQGTINLNQCVDVVDGESRTGQKHSL 122

  Fly   160 AITAPERVTFVKGTSSEESQWWLNILAAFP---KSKGRHKRSATLPGGQVVGSLRPT------SN 215
            .|..|::..:::..|.|....|...|..||   |...:.||....|..|..|..:.|      |:
Zfish   123 CICTPDKDHYIRAESKETIHGWQEALMVFPRTNKQNQKKKRKVETPTPQEPGPAKVTVTSTSSSS 187

  Fly   216 GDLTLSTKLGN------------RHSSYHKDTLTSSQSAGNLLSSLDLGPSST---KTAGSPLTT 265
            ..:.|.:.:.:            :..::.:.||.:|.|.|: ||.||.|.|:.   ....|...:
Zfish   188 SMVCLPSTIAHAERVPATRTTLWQEETWSRATLPTSCSTGS-LSQLDSGNSNVGRKPRVESGYFS 251

  Fly   266 TQSALADDEEDDGVETGEDVDEDEEDE---------------TSVPRKSKTVSMGGQ-------- 307
            .:....:||       |:.....:|:|               :|...:|:.:|...:
Zfish   252 LEKPKIEDE-------GQQYHLQQEEEPPSKLQSHPPELSSSSSSSSRSRYLSFDPELYSSPISS 309

  Fly   308 ---------------------DENNRNAGNEITNRVSQPTTCLLIEDIRRDEKTI---------- 341
                                 |.:..|..::....:||.:..|....:.||....
Zfish   310 HKHTSHDPHSTVHTQASSVVCDAHKHNMQSKSEKHLSQSSEILSDSTLNRDSNIYSPNPHANVLP 374

  Fly   342 KDIANTITNLSQQQNKRWSTAVNNALNNQHHFG----------------HHSQYQVTSRDETDFQ 390
            ..::::.::|..:|:.  .:.|..||......|                |...|:.:.:.:
Zfish   375 SSLSSSQSSLDSEQSP--ESVVGGALGRAGRSGCGYVALADVPRARRLSHRDAYRCSQKRQ---- 433

  Fly   391 MSSNSSSTKSQNPASER--------------------------PKSLPLASNST-PAIVSAIVKK 428
                ....::::|..|.                          |:.:...|:|| ||  .:..|.
Zfish   434 ----ELRARTRSPGREEVERLFGCQRRRSQVIERFEGQDTVNAPEQMDTTSSSTDPA--PSYSKT 492

  Fly   429 IPTVMEQGDKTKPTARLQLHLKSPKHYQHERGDPDGGCNLDELCVNYMAKTDELRSVGKANSKSS 493
            ......:.:|.....:.:..|.|.|            |..||  |:.:|.....:|:.:..:::.
Zfish   493 ANQRAGRNEKRLSNQKQEFSLDSAK------------CRTDE--VSSLAGYRRAKSLDRRTTETL 543

  Fly   494 SGQGKPPVKEESLNAKKGWLMK--QDNRTCEWSKHWFTLSGAALFYYRDPLCEERGVLDGVLDVN 556
                   :..:.||.||||:.|  :|..   |.||||.|:..:|.:|||.:.||...|||.:|:
Zfish   544 -------MTPDLLNFKKGWMTKLYEDGL---WKKHWFVLTDQSLRFYRDSIAEEASDLDGEIDL- 597

  Fly   557 SLTSVIPEPAASKQHAFQLTTWDKQRLVLASLSPSSRNSWL-AVLRS------------------ 602
            ||...:.|....:.:.||:.: .:....|::::...|.:|: |:|::
Zfish   598 SLCYDVTEFPVQRNYGFQILS-KEGAFTLSAMTSGIRRNWIQAILKNMRPTVAPDVTRKNVSLKL 661

  Fly   603 ----AAGLPQLDTPPKQTDIEQDFIKAQLQQPSSSPVTPGTP-------AGPHFSSDEEYRTASE 656
                .:.||...|   ::::||.||:...|..:||.|.|..|       |.|  ....:.|....
Zfish   662 SVLMPSSLPDERT---RSNVEQSFIQPPSQLSNSSIVEPKRPHEDITDSAPP--PDQRKSRGHKR 721

  Fly   657 GGRRDSLDW-----GSPLSPSPPVLRSCLRNRSLASLHKRSRSSPPSSRRS--TVDSVA----SD 710
            .||..:.||     |.......|.|:....:..::|......|||.||..|  |..|:.    ::
Zfish   722 EGRSKTFDWSEFRPGQENESGQPSLKRADTSVIISSSPSSIASSPISSSSSHQTSSSITIISHTE 786

  Fly   711 ELP-------LLV-------------------------VPEE---MQPTESRELKQQCE---TLR 737
            :||       .:|                         ||:|   :...:|||: |:.:   .:|
Zfish   787 KLPQHNEEEEQVVQEYVPHHQTVPTTMTGPETPSNPHNVPQEPAGIDLNQSREV-QEVDGHGVIR 850

  Fly   738 AEASLR---EARMSELLATLQRTEQQL----------------TARLQEQQQQLNSELTQAKQSA 783
            ..:.::   |.|..::..|..|.|:|:                .|..||:..:|..||.||::
Zfish   851 KNSDVQVEIEQRWHQVETTPLREEKQVPIAGGSPNVSNVSVGERASPQEKTSKLEKELGQAQK-- 913

  Fly   784 SDLMHNLGMQLTESQCQIKQLEDRL--AQGIEEN--EGL-------------------------Y 819
                     :|...|.|...|:|:|  |:|.|:|  ||.                         :
Zfish   914 ---------ELARLQEQNSILQDQLQDARGREQNAREGYVLQNDSTIAKPSSDAPVSTTVHKAPW 969

  Fly   820 KRL--------RELQAQDHSGGAA---LSNLQR----------HKIKRMDSLSDLTTI------- 856
            :||        .||::|......|   :|:|:|          |....:::|.:..|.
Zfish   970 QRLSKLNQDLKSELESQRRKQDKAKHQVSSLRRSYSEAKDIIGHHEAEIEALEEKLTAAMAEIVV 1034

  Fly   857 ---------SDID---PYCLQRDSLAEEY--NE--LRSRFEKAVNEIRAMKRELKQSQNQYDALE 905
                     ||:.   ..|.:|:   ||:  ||  |||:.:.:...:|.::..|.: :||    |
Zfish  1035 SEQAVARMRSDLKIERVRCQERE---EEWTRNETTLRSQLQDSEERLRQVEASLLE-KNQ----E 1091

  Fly   906 LAQAALQQKLERRQHEDGAQLQLMAARIQDLTLKYSSS-------------------ERQVRALK 951
            |.|...||.|:|.||.:..:||...|......:....|                   ||:.:.|.
Zfish  1092 LRQLEQQQALQRDQHREMQRLQERLAEATGRLISMEESQTMREERERKEHRSLEEKHERERQGLT 1156

  Fly   952 QKLAKSERRRSLSLKGKEQLELKLSELQRETVERKEGTPPESSSSESSSQSPLNAHLLQRLHSLE 1016
            ::||:||.||       :::|.:|.|.|    |:.|.....||..|:       ..|.:::|
Zfish  1157 RRLAESEERR-------QEIEEQLQEAQ----EQVEALLRGSSGMET-------VGLREQVH--- 1200

  Fly  1017 HVLLGSKERLEQSL-TQLQQIRAGQRTRRSVSPMNDRKDGL----RQLERALAETCVMVSEQME- 1075
                    ||:|.| ||...:   :..|.||..:.:.:|.|    ::|...:||....|.:|..
Zfish  1201 --------RLQQELETQTDMV---EMLRESVRRLEEERDQLTCRCQELLNQIAEADREVGKQQAC 1254

  Fly  1076 LTCLQDSCHKCCDLRQRVE----KLSALQQQTETDLQRS----EQLLEQRETDLAQALEKCA--- 1129
            ||.::...|......:.|.    ::|.:.|:.|.:::::    |.|:.|:|.||::||.|.|
Zfish  1255 LTTVETDFHSLETSYEHVSEEFARISHVLQEKEEEVRQTKEMYEHLIRQKEQDLSEALIKMAALG 1319

  Fly  1130 SQEQEQELLLQQRQELSEELGRQQE---RCRRLEKRLE---LLEREHGKQLECLREVYHTEHANA 1188
            |..:|.||.|||::||..::.|...   ..|:.|:.|:   ::..:...:||        ||.||
Zfish  1320 SSLEETELCLQQKEELLSKMERDYPGLVESRKAEQELQAKLVVAEDRIAELE--------EHLNA 1376

  Fly  1189 -----ADEQSFRKRYQTE-IEQLRTLCEKGLSAMETSHKRLTMDLEQKHKMEIERLLAEKETALA 1247
                 ||.:..|.|.|.: :|.|:.:                                |.|.:|:
Zfish  1377 LRLGYADLRMRRCRSQEDMLESLKEI--------------------------------EHEVSLS 1409

  Fly  1248 EETQATLAALDAMRKAHQSE---VQREVARFK----QEFLRQVQRGEQMRGDGAKLK-EEDLGEL 1304
            ..|...||     |.:.::|   |:|:..||.    |.:.|. |..::.:.:...|. .:||...
Zfish  1410 SSTSQLLA-----RSSSETEMSLVKRQRIRFSTIQCQTYHRS-QGADKFQTENTSLDLTQDLSLD 1468

  Fly  1305 RMEILAFSEKYSI-------KCVENA-------ALEEKLHMANSKLRHFQQMQQLELRNKQFRAH 1355
            .|..|:.::..|:       :|.:..       |||.||.....||||.....:.:......:.|
Zfish  1469 HMHDLSLTQDISVVSDNSFQQCRDPEKFISIIHALETKLLATEEKLRHLTDKIRDQPNLSAVQEH 1533

  Fly  1356 LASDDPSNDVHFVQGLTSDARED---ADCED---SEPAPQILGATATRTTATTTTTATATTTSAA 1414
            |:              |....||   ..|:|   .||:.:.|..|.:...:.....|.|...|..
Zfish  1534 LS--------------TRATMEDWTTKTCDDLPMDEPSQKHLNKTVSEHDSGEYEKALALVESCT 1584

  Fly  1415 PSETE----SNPDSDRETADSSRAPPEK--MEQSLFVIPSHMLNSSLVPAANASDQSQRSQLYRD 1473
            ....|    .|..|..|:...:.|..||  :..:.|:...|.|
Zfish  1585 ERVREILSNQNETSSAESLICTLAEVEKRLVCATAFLRKGHTL---------------------- 1627

  Fly  1474 LDGPEDGYEPCYRPFDIFAIYQNRLSYQGLKGS-STFGKSL 1513
                   ||.|: .||...:       |.:||| ..|.::|
Zfish  1628 -------YESCH-VFDAPDV-------QSMKGSIKLFARTL 1653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942	47/146 (32%)
		PH	85..185	CDD:278594	33/100 (33%)
		PH_M-RIP	509..613	CDD:270094	35/128 (27%)
		PH	509..603	CDD:278594	32/118 (27%)
		SbcC	726..1353	CDD:223496	181/791 (23%)
si:ch73-103b11.2	XP_005162957.1	PH_RIP	19..154	CDD:269942	49/145 (34%)
		PH	47..148	CDD:278594	34/105 (32%)
		PH_M-RIP	552..653	CDD:270094	32/105 (30%)
		PH	552..645	CDD:278594	32/97 (33%)
		SbcC	<1847..2413	CDD:223496
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9570
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4051
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002350
OrthoInspector	1	1.000	-	-		otm25629
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR17271
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3426
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.150