DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and Triobp

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	XP_017450472.1	Gene:	Triobp / 362956	RGDID:	1308485	Length:	1946	Species:	Rattus norvegicus

Alignment Length:	952	Identity:	220/952 - (23%)
Similarity:	344/952 - (36%)	Gaps:	347/952 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 DIANTITNLSQQQNKRWSTAVNNALNNQHHFGHHSQYQVTSRDETDFQMSSNSSSTKSQNPASER 407
            |..:|:...||.|.:.|:.|   .|.|.|..|..                            ||.
  Rat  1289 DTEDTLKTESQTQPEGWAKA---TLANGHRPGQQ----------------------------SES 1322

  Fly   408 PKSLPLASNSTPAIVSAIVKKIPTV-MEQGDKTKPTARLQL--HLKSPKHYQHERGDPDGGCNLD 469
            |..||     :||..|.   :.||. :..|.:|.|...|:.  ||:|       ...||.|.:|
  Rat  1323 PAQLP-----SPACTST---QWPTTKVTSGPETSPPVALEQIDHLES-------HSPPDLGPDL- 1371

  Fly   470 ELCVNYMAKTDELRSVGKANSKSSSGQGKPPVKEESLNAKKGWLMKQDNRTCEWSKHWFTLSGAA 534
                                                ||.||||:...| ...||.||||.|:.::
  Rat  1372 ------------------------------------LNFKKGWMSILD-EPGEWKKHWFVLTDSS 1399

  Fly   535 LFYYRDPLCEERGVLDGVLDVNSLTSVIPEPAASKQHAFQLTTWDKQRLVLASLSPSSRNSWLAV 599
            |.||||...||...|||.:|:.|.|.| .|.|..:.:.||:.|.|.. ..|::::...|.:|:..
  Rat  1400 LKYYRDSTAEEADELDGEIDLRSCTDV-TEYAVQRNYGFQIHTKDAV-YTLSAMTSGIRRNWIEA 1462

  Fly   600 LR------SAAGLPQLDTPPKQTDI-----EQDFIKAQLQQPSSSPVTPGTPAGPHFSSDEEYRT 653
            ||      ||..:.:|....|:..:     ::..:|...|:..|..:..|.|
  Rat  1463 LRKTVRPTSAPDVTKLSECNKENTLHGYGTQKSSLKIGEQRTGSEVIGRGGP------------- 1514

  Fly   654 ASEGGRRDSLDWG--SPLSPSPPVLRSCLRNRSLASLHKRSRSSPPSSRRSTVDSVASDELPLLV 716
            ....|.|.|||:.  |||:||.|     .|.|:|      |||:|.
  Rat  1515 RKVDGSRQSLDYVELSPLTPSSP-----QRVRTL------SRSTPE------------------- 1549

  Fly   717 VPEEMQPTESRELKQQCETLRAEASLREARMSELLATLQRTEQQLTARLQEQQQQLNS--ELTQA 779
                 :|::..:|                            |:.|..|.:|:::...|  ..|..
  Rat  1550 -----RPSKQEDL----------------------------ERDLAQRSEERRKWFESTDSRTPE 1581

  Fly   780 KQSASDLMHNLGMQLTESQCQIKQLEDRLAQGIEENEGLYKRLRELQAQDHSGGAALSNLQRHKI 844
            ..|.......||..||:.|      :.||::.||      |:.:||:           .|...:.
  Rat  1582 TPSGDGSRRGLGAPLTDDQ------QSRLSEEIE------KKWQELE-----------KLPLREN 1623

  Fly   845 KRMDSLSDLTTISDIDPYCLQRDSLAEEYNELRSRFEKAVNEIRAMKRELKQSQNQYDALELAQA 909
            ||:    .||.:            |.:.::|.|.   ...:...|:::|::..:.|.:|..|...
  Rat  1624 KRV----PLTAL------------LNQGHSERRG---PTSDSHEALEKEVQSLRAQLEAWRLRGE 1669

  Fly   910 ALQQKLERRQHEDGAQLQLMAARIQD---LTLKYSSSERQVRALKQKLAKSERRRSLSLKGKEQL 971
            |.|.                |.|:|:   :...|.|.|    |.::.||:.|   |...:..|||
  Rat  1670 APQN----------------APRLQEDSHIPPGYISQE----ACERSLAEME---SSHQQVMEQL 1711

  Fly   972 ----ELKLSELQRETVERKEGTPPESSSSESSSQSPLNAHLLQRLHSLEHVLLGSKERLEQSLTQ 1032
                |.:|..||:|    ||....|.:::.:|              ::|.:....:|.|.:.|::
  Rat  1712 QRHHERELQRLQQE----KEWLLAEETAATAS--------------AIEAMKKAYQEELSRELSK 1758

  Fly  1033 LQQIRAGQRTRRSVSPMNDRKDGLRQLERALAETCVMVSEQMELTCLQDSCHKCCDLRQRVEKLS 1097
            .:.::.|        |.:.||.....:| ||.:...::||:....||:               :.
  Rat  1759 TRSLQQG--------PDSLRKQHQLDME-ALKQELQVLSERYSQKCLE---------------IG 1799

  Fly  1098 ALQQQTETDLQRSEQLLEQRETDLAQALEKCASQEQEQELLLQQRQE----LSEEL--------- 1149
            ||.:|.           |:||..|     :|..||.::  ||:..||    ||||:
  Rat  1800 ALTRQA-----------EEREHTL-----RCCQQEGQE--LLRHNQELHSHLSEEIDRLRSFIAS 1846

  Fly  1150 -------GRQQER--CRRLEKRLELLERE---HGKQLECLREVYHTEHANAADEQSFRKRYQ--- 1199
                   ||..||  | .||..|.:.|.|   ..|:::|||:    |......::.|..:||
  Rat  1847 QGTGNSCGRSNERSSC-ELEVLLRVKENELQYLKKEVQCLRD----ELQVIQKDKRFTGKYQDVY 1906

  Fly  1200 TEIEQLRTLCEKGLSAMETSHKRLTMDLEQKHKMEIERLLAE 1241
            .|:..::|..|:.:..:: .|.||.|...|: |..:...|||
  Rat  1907 VELNHIKTRSEREIEQLK-EHLRLAMAALQE-KEAVRNSLAE 1946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942
		PH	85..185	CDD:278594
		PH_M-RIP	509..613	CDD:270094	40/109 (37%)
		PH	509..603	CDD:278594	37/99 (37%)
		SbcC	726..1353	CDD:223496	121/553 (22%)
Triobp	XP_017450472.1	PHA03307	24..>342	CDD:223039
		Herpes_BLLF1	<241..763	CDD:282904
		PHA03247	<629..1070	CDD:223021
		PH_M-RIP	1375..1476	CDD:270094	39/103 (38%)
		Smc	<1635..1946	CDD:224117	93/403 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338263
Domainoid	1	1.000	67	1.000	Domainoid score	I9591
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002350
OrthoInspector	1	1.000	-	-		otm46156
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR17271
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030