DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and step

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster

Alignment Length:	704	Identity:	140/704 - (19%)
Similarity:	237/704 - (33%)	Gaps:	224/704 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTTTITTTVPAAPSKSAPPTPTTTGAAGATTNARTADCRKFTPNIFNKSKCSHCFRQREEHSAA 65
            ::|..||...|.:|    ||       |..|.:.:|.:|...|..:....:
  Fly   162 VATYNITKLAPDSP----PP-------ASPTLSTQTVNCSDVTTKVTEVQR-------------- 201

  Fly    66 ALECNRRTSSNLAEPASRKVSKCGYLFVAPDWDFSNPLYRTKRWQRRWFVLYDDGELTYSVDDYP 130
             |.|:        ||.:..:||                 ||                     :|.
  Fly   202 -LPCD--------EPNTELISK-----------------RT---------------------EYK 219

  Fly   131 ETIPQACVDMTKVLEVTSAVEVTGHPNS--IAITAPERVTFVKGTSSEESQWWLNI--------- 184
            .|   .....|:.|.|:..||:..:.|.  ||..:|.:      :.|......|::
  Fly   220 HT---TITTTTRTLIVSRPVELLLNENGEIIARRSPRK------SRSNSLGRMLDVQNEIGTGGL 275

  Fly   185 -LAAFPKSKGRHKRSATLPGGQVVGSLR---PTSNGDLTLSTKLGNRHSSYHK-----------D 234
             :.|.|.||.      :||....:..:|   .:||     |.....|:|:.||           |
  Fly   276 FMEADPCSKN------SLPPPPYIDDMRFIDDSSN-----SQSESERNSNIHKTNKYTSKNNNND 329

  Fly   235 TLTSSQSAGNLLSS----LDLGPSSTKTAGS-PLTTTQSALADDEEDDGVETGEDVDEDEEDETS 294
            :...||.: ||..|    ||....:|:.:.: .:....|....||..:.|...|.:|..|:.:.|
  Fly   330 SKRESQQS-NLCESCRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHS 393

  Fly   295 VPRKSKTVSMGGQDEN-NRNAGNE--ITNRVSQPTTCLLIEDIRRDEKTIKDIANTITNLSQQQN 356
              .|.|.:|:|.:..| :...|.|  :.||:           :|.|.   :|:|:.:.. .:..|
  Fly   394 --NKDKQMSIGRKKFNMDPKKGIEYLVENRL-----------LRHDP---QDVAHFLYK-GEGLN 441

  Fly   357 KRWSTAVNNALNNQHHFGH---------HS-----------QYQVTSRDETDFQMSSNSSSTKSQ 401
            |   ||:.:.|..::.|..         |.           |:..:.|...:.|.......|.:|
  Fly   442 K---TAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQ 503

  Fly   402 NPASERPKSLPLASNSTPAIVS-AIVKKIPTVMEQGDKTKPTARLQLHLKSPKHYQHERGDPDGG 465
            ......|..  ..:..|..::| ||:....::.....|.|||.        .:.....||..:||
  Fly   504 RYCQLNPDI--FTNTDTCYVLSFAIIMLNTSLHNPSVKDKPTV--------DQFISMNRGINNGG 558

  Fly   466 CNLDELCVNYMAKTDELRSVGKANSKSSSGQGKP-PVKEESLN---------AKKGWLMKQDNRT 520
                          |..|  |...|...|.:.:| .:.::..|         .|:|||.||..|.
  Fly   559 --------------DLPR--GLLESLYESIRTEPFKIPQDDGNDLMHTFFNPDKEGWLWKQGGRY 607

  Fly   521 CEWSKHWFTLSGAALFYYRDPLCEE-RGVLD----GVLDVNSLTSVIPEPAASKQHAFQLTTWDK 580
            ..|.:.||.|:...|:|:.....:| ||::.    .|.:::.         .||.|.|:|.....
  Fly   608 KSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIHD---------RSKPHCFELFATGG 663

  Fly   581 QRLVLASLSPSSRNSWLAVLRSAAGLPQLDTPPKQTDIEQDFIKAQLQQPSSSP 634
            ..::.|..:.|...    |:.....:.::....::.  :|::||...|..|.:|
  Fly   664 ADIIKACKTDSEGK----VVEGKHTVYRMSAATEED--QQEWIKRLTQSISHNP 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942	23/154 (15%)
		PH	85..185	CDD:278594	17/111 (15%)
		PH_M-RIP	509..613	CDD:270094	25/108 (23%)
		PH	509..603	CDD:278594	25/98 (26%)
		SbcC	726..1353	CDD:223496
step	NP_001036375.2	Sec7	397..577	CDD:279680	42/223 (19%)
		PH_GRP1-like	592..710	CDD:269954	30/132 (23%)
		PH	596..708	CDD:278594	29/126 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910