DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment osp and PLEK2

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	NP_057529.1	Gene:	PLEK2 / 26499	HGNCID:	19238	Length:	353	Species:	Homo sapiens

Alignment Length:	289	Identity:	57/289 - (19%)
Similarity:	99/289 - (34%)	Gaps:	65/289 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 SQQQNKRWSTAVNNALNNQHHFGHHSQYQVTSRDETDFQM--------------SSNSSSTKSQN 402
            |:::...|:..:..|:    |.|...:.|........|::              .||:....|.|
Human    88 SREERDAWAFEITGAI----HAGQPGKVQQLHSLRNSFKLPPHISLHRIVDKMHDSNTGIRSSPN 148

  Fly   403 --PASERPKSLP-------LASNSTPAIVSAIVKKIPTVMEQGDKTKPTARLQLHLKSPKHYQHE 458
              ..|...|:..       |.|||..|.....|.....:||: :..:|.....:
Human   149 MEQGSTYKKTFLGSSLVDWLISNSFTASRLEAVTLASMLMEE-NFLRPVGVRSM----------- 201

  Fly   459 RGDPDGGCNLDELCVNYMAKTDELRSVGKANSKSSSGQGKPPVKEESLN--------AKKGWLMK 515
                 |.....:|...::..:..|.:..::..|..|     |.:|.||:        .|:|:|.|
Human   202 -----GAIRSGDLAEQFLDDSTALYTFAESYKKKIS-----PKEEISLSTVELSGTVVKQGYLAK 256

  Fly   516 QDNRTCEWSKHWFTL-SGAALFYYRDPLCEERGVLDGVLDVNSLTSVIPE---PAASKQHA---- 572
            |.::...|....|.| ...|..:|.||..||...:.|.....||.|.:.:   |...|.:.
Human   257 QGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSLVSALEDNGVPTGVKGNVQGNL 321

  Fly   573 FQLTTWDKQRLVLASLSPSSRNSWLAVLR 601
            |::.|.|.....:.:.|.:.|..|:..::
Human   322 FKVITKDDTHYYIQASSKAERAEWIEAIK 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942
		PH	85..185	CDD:278594
		PH_M-RIP	509..613	CDD:270094	26/101 (26%)
		PH	509..603	CDD:278594	26/101 (26%)
		SbcC	726..1353	CDD:223496
PLEK2	NP_057529.1	PH1_Pleckstrin_2	3..113	CDD:270113	5/28 (18%)
		PH	5..95	CDD:278594	1/6 (17%)
		DEP_PLEK2	128..236	CDD:239891	21/129 (16%)
		PH2_Pleckstrin_2	242..353	CDD:270114	26/109 (24%)
		PH	248..352	CDD:278594	26/103 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910