DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and GAB1

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	XP_016863455.1	Gene:	GAB1 / 2549	HGNCID:	4066	Length:	738	Species:	Homo sapiens

Alignment Length:	815	Identity:	159/815 - (19%)
Similarity:	279/815 - (34%)	Gaps:	238/815 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 LYRTKR-WQRRWFVLY------DDGELTYSVDDYPETIPQACVDMTKVLEVTSAVEVT--GHPNS 158
            ||:.|: |:||||||.      |...|.|..:|:.:. |...:|:....:|.:.:...  ...||
Human     6 LYKKKKAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKK-PIRIIDLNLCQQVDAGLTFNKKEFENS 69

  Fly   159 --IAITAPERVTFVKGTSSEESQWWLNILAAFPKSKGRHKRSATLPGGQVVGSLRPTSNGDLTLS 221
              ..|...:|:.::...|.||...|:..:..........:.....||    .||:..::..|.::
Human    70 YIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPG----SSLQAPADLPLAIN 130

  Fly   222 TKLGNRHSSYHKDTLTSSQSAGNLLSSLDLGPSSTKTAG-----------------SPLTTTQSA 269
            |...:..:.....||.......|:       |...:|.|                 .|..|:|.:
Human   131 TAPPSTQADSSSATLPPPYQLINV-------PPHLETLGIQEDPQDYLLLINCQSKKPEPTSQGS 188

  Fly   270 LADDEEDDGVETGED--VDEDEEDETSVPRKSKTVSMGGQDENNRNAGNEITNRVSQPTTCLLIE 332
            ....||      ||:  :.||.|        |||:.:....::.::..:|              .
Human   189 SFVSEE------GEEYLLLEDFE--------SKTIPLQTHADSAKSTSSE--------------T 225

  Fly   333 DIRRDEKTIKDIANT-----ITNLSQQQ-------NKRWSTAVNNALNN-QHHFGHHSQYQVT-S 383
            |...:..:.|:.|::     :....|||       ::..|.:|:::|.| ...:.|....:|: |
Human   226 DCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPS 290

  Fly   384 RDETD-----FQMSSNSSSTKSQNPASERPKSLPLASNSTPAIVSAIVKKIPTVMEQGDKTKPTA 443
            ..|.|     |...|.:||.::|.........:|....:|        .:||....:|...: |:
Human   291 STEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNT--------YQIPRTFPEGTLGQ-TS 346

  Fly   444 RLQL-----HLKSPK-HYQHERGDPDGGCNL--------DELCV----------NYMAKTD--EL 482
            :|..     ..:.|| |..|:| .|...|::        ...|:          |.::..|  :|
Human   347 KLDTIPDIPPPRPPKPHPAHDR-SPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKL 410

  Fly   483 RSVGKA-----------NSKSSSGQG------------KPPVKEESLNAKKGWLMKQDNRTCEWS 524
            |....:           :.:|||.:|            ...|..|.|:  :.::....|......
Human   411 RKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELD--ENYVPMNPNSPPRQH 473

  Fly   525 KHWFTLSGAALFYYRDPLCEERGV--LDGVLDVNSLTSVIPEPAASKQHAFQLT--TWDKQRLVL 585
            ...||          :|:.|...|  ..|..|.:|....:|.||   ...|:.:  |..::.:.:
Human   474 SSSFT----------EPIQEANYVPMTPGTFDFSSFGMQVPPPA---HMGFRSSPKTPPRRPVPV 525

  Fly   586 A---------SLSPSSRNSWLAVLR-SAAGLPQLDT------------PPKQTDIEQDFIKAQLQ 628
            |         :|.|..:.....:|| ...||.:.|:            .|...:|:......:||
Human   526 ADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQ 590

  Fly   629 QPSSSPVTPG-------TPAGPHFSSDEEYRTASEGGRRDSLDWGSPLSPS-----PPVLRSCLR 681
            .|..||:|..       .|..|.  .|..:.|.|.....||.:...|::|:     |.:..|...
Human   591 APVRSPITRSFARDSSRFPMSPR--PDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSL 653

  Fly   682 NRSLASLHK---------------RSRSSPPSSRRS--TVDSVASDELPLLVVPEEMQPTESREL 729
            :...:.:.|               ..:|:||..::|  :..|||.:.:..:||.::
Human   654 DGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQ--------- 709

  Fly   730 KQQCETLRAEASLREARMSELLATLQRTEQQLTAR 764
                :|| |..|.|||...    ..|.||.:..|:
Human   710 ----KTL-ALKSTREAWTD----GRQSTESETPAK 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942	25/98 (26%)
		PH	85..185	CDD:278594	25/92 (27%)
		PH_M-RIP	509..613	CDD:270094	22/129 (17%)
		PH	509..603	CDD:278594	19/107 (18%)
		SbcC	726..1353	CDD:223496	11/39 (28%)
GAB1	XP_016863455.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910