DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and ACAP2

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	XP_016861535.1	Gene:	ACAP2 / 23527	HGNCID:	16469	Length:	848	Species:	Homo sapiens

Alignment Length:	921	Identity:	176/921 - (19%)
Similarity:	310/921 - (33%)	Gaps:	251/921 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 CLLIEDIRRDEKTIKDIANTITNLSQQQNKRWSTAVNNALNNQHHFGHHSQYQVTSRDETDFQMS 392
            ||  :|..|....::::...:..|..:.:|.....:......:.....:.|:....||..  |.|
Human    10 CL--KDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLA--QYS 70

  Fly   393 SN-----SSSTKSQNPASER---------PKSLPLASNSTPAIVSAIVKKIPTVMEQGDKTKPTA 443
            ||     :|.||..:...|.         |.||.|....  .|::.:.:.....|...|:|:.:.
Human    71 SNDAVVETSLTKFSDSLQEMINFHTRQGLPLSLRLECRG--MIIALLWESSHLRMILFDQTQRSI 133

  Fly   444 RLQLHLKSPKHYQHERGDPDGGCNLDELCVNYMAKTDELRSVGKANSKSSSGQGKPPVKEESLNA 508
            :.||.                         |::  .::||....|..:...      |.||..||
Human   134 KAQLQ-------------------------NFV--KEDLRKFKDAKKQFEK------VSEEKENA 165

  Fly   509 --KKGWLMKQDNRTCEWSKHWFTLSGAALFYYRDPLCEERGVLDGVLDVNSLTSVIPEPAASKQH 571
              |...:.:......|.:.:..|.:..         |.....||.||.:|.|.|...........
Human   166 LVKNAQVQRNKQHEVEEATNILTATRK---------CFRHIALDYVLQINVLQSKRRSEILKSML 221

  Fly   572 AF---QLTTWDKQRLVLASLSPSSRNSWLAVLRSAAGLPQL--DTPPKQTDIEQDFIKAQLQQPS 631
            :|   .|..:.:...:.:.|.|..::       ..|.|.:|  |...::.::||.  .:.:||..
Human   222 SFMYAHLAFFHQGYDLFSELGPYMKD-------LGAQLDRLVVDAAKEKREMEQK--HSTIQQKD 277

  Fly   632 SSPVTPGTPAGPHFSSDE---EYRTASEGG--------RRDSLDWGSPLSPSPPVLRS--CLRNR 683
                         ||||:   ||...:..|        :|.|..:.:.....|..:|.  .::|.
Human   278 -------------FSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRKKPDHIRRWFSIQNN 329

  Fly   684 SLASLHKRSRSSPPSSRRSTVDSVASDELPLLVVP-----------EEMQPTESRELKQQCETLR 737
            .|. ..|:.:.:|         :|..::|.|..|.           |.:.||:|..|:...|.||
Human   330 QLV-YQKKFKDNP---------TVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLR 384

  Fly   738 AEASLREARMSELLATLQRTEQQLTARLQEQQQQLNSELTQAKQSASDLMH-NLGMQLTE----- 796
             :|.::..:.|  :||..|.:...:.:|.::.......|....:|...|:. ...:|..:
Human   385 -QAWIKAVQTS--IATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGN 446

  Fly   797 -SQCQIKQLEDRLAQ---GIE---ENEGLYKRLRELQAQDHSGGAALSNLQRHKIKRMDSLSDLT 854
             |.|.....:.|.|.   ||.   |..|:::.|          |...|     |::.:
Human   447 ASCCDCGLADPRWASINLGITLCIECSGIHRSL----------GVHFS-----KVRSL------- 489

  Fly   855 TISDIDPYCLQRDSLAEEYNELRSR-FEKAVNEIRAMKRELKQSQNQYDALELAQAALQQKLERR 918
            |:...:|..|:  .:.|..|::.:| :|..|.::...|.:..|.|.:       :|.::.|...|
Human   490 TLDTWEPELLK--LMCELGNDVINRVYEANVEKMGIKKPQPGQRQEK-------EAYIRAKYVER 545

  Fly   919 QHEDGAQLQLMAARIQDLTLKYSSSERQVRALKQKLAKSERRRSLSLKGKEQLELKLSELQRETV 983
            :..|                |||.|          |:..|:::....|..|:..|.:|
Human   546 KFVD----------------KYSIS----------LSPPEQQKKFVSKSSEEKRLSIS------- 577

  Fly   984 ERKEGTPPESSSSESSSQSPLNAHLLQRLHSLEHVLLGSKERLEQSLTQLQQIRAGQRTRRSVSP 1048
              |.|...:..:|..||...:|:...:|........|.|......:.::|:.||:..   ..:..
Human   578 --KFGPGDQVRASAQSSVIAVNSDEARRESLFCPDELDSLFSYFDTSSKLRSIRSND---SGIQQ 637

  Fly  1049 MNDRKDGLRQLERALAETCVM--VSEQMELTCLQDSCHKCCDL---RQRVEK-----LSALQQQT 1103
            .:|  ||...|...::...:.  ..|:.:.:...||.|....|   |...||     ..||....
Human   638 SSD--DGRESLPSTVSANSLYEPEGERQDSSMFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGA 700

  Fly  1104 ETDLQRSEQLLEQRETDLAQA-----LEKCASQEQEQELLLQQRQELSEE-------------LG 1150
            :.:...||   |.:.|.|.||     |..|       |.|||....:::.             ||
Human   701 DVNWANSE---ENKATPLIQAVLGGSLVTC-------EFLLQNGANVNQRDVQGRGPLHHATVLG 755

  Fly  1151 RQQERCRRLEK 1161
            ...:.|..|::
Human   756 HTGQVCLFLKR 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942
		PH	85..185	CDD:278594
		PH_M-RIP	509..613	CDD:270094	19/108 (18%)
		PH	509..603	CDD:278594	15/96 (16%)
		SbcC	726..1353	CDD:223496	95/478 (20%)
ACAP2	XP_016861535.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910