DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and MPRIP

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	XP_011522064.1	Gene:	MPRIP / 23164	HGNCID:	30321	Length:	2444	Species:	Homo sapiens

Alignment Length:	1953	Identity:	418/1953 - (21%)
Similarity:	713/1953 - (36%)	Gaps:	554/1953 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VPAAPSKSAPPTPTTTGAAGATTNARTADCRKFTPNIFNKSKCSHCFRQREEHSAAALECNRRTS 74
            |.|||:.||               |:...||||..||||||||.:||:.||.|..
Human    27 VAAAPTMSA---------------AKENPCRKFQANIFNKSKCQNCFKPRESHLL---------- 66

  Fly    75 SNLAEPASRKVSKCGYLFVAPD-WDFSNPLYRTKRWQRRWFVLYDDGELTYSVDDYPETIPQACV 138
             |..:....|....|:|.:||| .||.||::|:::||||:|:||:.|.|.|::|:.|.|:||..:
Human    67 -NDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTI 130

  Fly   139 DMTKVLEVTSAVEVTGHPNSIAITAPERVTFVKGTSSEESQWWLNILAAFP---KSKGRHKRSAT 200
            :|.:..:|......||...|:.|..||:..|::..:.|....||.:|..:|   |...:.||...
Human   131 NMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVE 195

  Fly   201 LPGGQVVG---------SLRPTSNGDLTLSTKLGNRHSS-YHKDTLTSSQSAGNLLS-------S 248
            .|..|..|         |...:|:..:..:.|:....|: :.::..|..|..|:.||       |
Human   196 PPTPQEPGPAKVAVTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQS 260

  Fly   249 LDLGPSSTKTAGSPLTTTQSALADDEEDDG----VETG----EDVDED---EEDETSVPRKSKTV 302
            .....||.:..|......:||::.|..|.|    ||:|    |...:|   ||.:...|....:.
Human   261 QPPAASSLREPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSP 325

  Fly   303 SMGGQ-----DENNRNAGNEITN---RVSQPTTC---LLIEDIRRDEKTIKDIANTITNLSQQQN 356
            |....     :..::..|..:.:   |:.....|   |...|:........|..:|    ..:..
Human   326 STPNHRYSCPESPSQELGGPLPSPGPRLPHQMVCSISLSSLDVASQPPAYVDSGST----RGRGT 386

  Fly   357 KRWSTAVNNALNNQH----------HFGHHSQYQVTSRDETDFQMSSNSSSTKSQNPASERPKSL 411
            :|..:|.....:.|:          ...|...:||..|        .....|::::|.  |.:..
Human   387 ERLGSAFAFKASRQYATLADVPKAIRISHREAFQVERR--------RLERRTRARSPG--REEVA 441

  Fly   412 PLASNSTPAIVSAIVKKIPTV-MEQGDKTK-------PTARLQLHLKSPKHYQHERGD------- 461
            .|..|....  |.:::|...: :|:.:..:       |::..:......:.:..:|..
Human   442 RLFGNERRR--SQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPA 504

  Fly   462 --PDGGCNLDELCVNYMAKTDELRSVGKANSKSSSGQGKPPVKEESLNAKKGWLMKQ--DNRTCE 522
              ||...:  .|..:..||:.:.||.            :|.|..:.||.|||||.||  |.   :
Human   505 PLPDASAS--PLSPHRRAKSLDRRST------------EPSVTPDLLNFKKGWLTKQYEDG---Q 552

  Fly   523 WSKHWFTLSGAALFYYRDPLCEERGVLDGVLDVNSLTSVIPEPAASKQHAFQLTTWDKQRLVLAS 587
            |.||||.|:..:|.||||.:.||...|||.:|:::...|...| ..:.:.||:.|.:.: ..|::
Human   553 WKKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSACYDVTEYP-VQRNYGFQIHTKEGE-FTLSA 615

  Fly   588 LSPSSRNSWLAVLRS----------AAGLPQ--------LDTPPKQTDIEQDFIKAQLQQPSSSP 634
            ::...|.:|:..:..          .:.||:        .:|.|:.|:.::    |:|.:|.
Human   616 MTSGIRRNWIQTIMKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQE----AELGEPD--- 673

  Fly   635 VTPGTPAGPHFSSDEEYRTASEGGRRDSLDWG-----------------------SPLSP--SPP 674
                 |......:.|..|.    ||..:.||.                       .||.|  .|.
Human   674 -----PEQKRSRARERRRE----GRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPG 729

  Fly   675 VLRSCLRNRSLASLHKRSR----------SSPPSSRRSTVDSVASDELPLLVVP----------- 718
            .|.   |.|:.....:|.|          .:..::.|..||  .|..||:..:.
Human   730 ELE---RERARRREERRKRFGMLDATDGPGTEDAALRMEVD--RSPGLPMSDLKTHNVHVEIEQR 789

  Fly   719 -EEMQPTESRELKQ---------------------QCETLRAEASLREARMSELLATLQRTEQQL 761
             .:::.|..||.||                     ....|..|....:...|:||...:..:.||
Human   790 WHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQL 854

  Fly   762 TARLQEQQQQ-----LNSELTQAKQSASDLMHNLGMQL---TESQCQIKQLEDRLAQGIEENEGL 818
            ...|..:|..     |.:|:..:...|...:|.:...|   .|:|||.::|.....|.::.:.|.
Human   855 RVALGREQSAREGYVLQTEVAASPSGAWQRLHRVNQDLQSELEAQCQRQELITHQIQTLKRSYGE 919

  Fly   819 YK-RLRELQAQDHSGGAALSNLQRHKIKRMDSLSDLTTISDIDPYCLQRDSLAEEYNELRSRFEK 882
            .| .:|..:|:..|..|.|||.......:..:|:.|            :..|..|...:|.:.|:
Human   920 AKDTIRHHEAEIRSLQARLSNAAAELAIKEQALAKL------------KGDLKREQGRVREQLEE 972

  Fly   883 AVNEIRAMKRELKQSQNQYDALELAQAAL------------QQKLER-RQHEDGAQLQLMAARIQ 934
            ..:...|:..:|:.|:.:   |:.|:|.|            ||.|:| ||.|    :|.:..||.
Human   973 RQHSEAALSSQLRASEQK---LKSAEALLLEKTQELRGLETQQALQRDRQKE----VQRLQERIA 1030

  Fly   935 DLTLKYSSSERQVRALKQKLAKS--------ERRRSLSLKGKEQLELKLSEL---------QRET 982
            ||:.:..:||:..|.:::||.::        |:.:...|:..:::|.|.|..         |.||
Human  1031 DLSQQLGASEQAQRLMEEKLQRNYELLLESCEKEKQALLQNLKEVEDKASAYEDQLQGQAQQVET 1095

  Fly   983 VERKEGTPPESSSSESSSQSPLNAHLLQRLHSLEHVLLGSKERLEQSLTQLQQIRAGQRTRRSVS 1047
            :::::    .|::.|.|.|          :|.||..|    |..|.|:.:|.:         .|.
Human  1096 LQKEK----LSATFEGSEQ----------VHQLEEQL----EAREASVRRLAE---------HVQ 1133

  Fly  1048 PMNDRKDGLRQLERALAETCVMVSEQMELTCLQDSC-----------HKCCDLRQRVEKLSALQQ 1101
            .:.|.:|.|||..:.|.|. |..|:: ::..|::..           |....:..:::.:..|.:
Human  1134 SLCDERDLLRQRFQELTER-VATSDE-DVAELREKLRRREADNQSLEHSYQRVSSQLQSMHTLLR 1196

  Fly  1102 QTETDLQR----SEQLLEQRETDLAQALEK---CASQEQEQELLLQQRQEL----SEELGRQQER 1155
            :.|.:|:|    .|::||::|.||.:||.|   ..|..:|.|:.||.::|:    :.|..:..|.
Human  1197 EKEEELERIKEAHEKVLEKKEQDLNEALVKMVALGSSLEETEIKLQAKEEILRKFASESPKDMEE 1261

  Fly  1156 CR------------------------------RLE----------------------------KR 1162
            .|                              |||                            |.
Human  1262 PRSTPEETERDGTLLPGQPVQATRAPLGLPHTRLEDEDEDLGAPPGEEYGDGSPSREDSMVPPKS 1326

  Fly  1163 LELLEREHGKQ---------------------LECLREVYHTEHANAADEQSFRKRYQTEIEQLR 1206
            :|:|:||..:|                     ::|.|.: |.|    ..|:::.....::..|.|
Human  1327 VEVLDREGHQQGTAKLDQGAPGVKRQRIRFSTIQCQRYI-HPE----GSEKTWTSSTSSDTSQDR 1386

  Fly  1207 TLCEKGLSA-----------------------------METSHKRLTMDLEQKHKMEIERLL--- 1239
            :..|:.:|:                             .|...|.:|:.||.:.....|.||
Human  1387 SPSEESMSSEPAPSVLPATGDSDTYLSIIHSLETKLYVTEEKLKDVTVRLESQQGQSREALLALH 1451

  Fly  1240 ---AEKETALAEETQATLAALDAMRKAHQSEVQREVARFK-----------------------QE 1278
               |..|..|.|:.:|:|..:.|:....:.|.|....|.:                       :|
Human  1452 HQWAGTEAQLREQLRASLLQVGALASQLEQERQERARRVEGHVGELGDFQVKNSQALMCLENCRE 1516

  Fly  1279 FLRQVQRGEQMRGDGAKLKEEDLGELRMEILAFSEKYSIKCVE-------------NAALEEKLH 1330
            .||.:.|..|          ||..:.|...||..|...:..::             .|.||....
Human  1517 QLRSLPRASQ----------EDEQDARAASLASVESALVSAIQALQHWPAPAHGGARAQLETGGT 1571

  Fly  1331 MANSKLRHFQQMQQLELRNKQFRAHLASDDPSNDVHFVQGLTSDAREDADCEDSEPAPQILGATA 1395
            ..|.|....||..|.|| .:|.:..|.||..:.:...:..: :|:.::...:.|....:|..:..
Human  1572 EENGKPASLQQCSQSEL-TEQEQVRLLSDQIALEASLISQI-ADSLKNTTSDVSRMLHEISWSGQ 1634

  Fly  1396 TRTTATTTTTATATTTSAAPSETESNPDSDR--------ETADSSRAPPEKMEQSLFVIPSHMLN 1452
            ....:......|.........|..|..:|.|        |...:|....:.:.|.|..|   :.|
Human  1635 PPMESAGAPVDTWARKVLVDGEFWSQVESLRKHLGTLGGEAVGASGDGQQSIPQGLAPI---LAN 1696

  Fly  1453 SSLVPA-ANASDQSQRSQLYRDLDGPED---GYEPCYRPF-----DIFAIYQ----NRLSYQGLK 1504
            ::.|.| .:.:.||.|...:|.|...::   |.:...|..     :|...||    .|:..|.|
Human  1697 ATWVRAELSFATQSVRESFHRRLQSIQETLRGTQTALRQHKCLLREILGAYQTPDFERVMQQVL- 1760

  Fly  1505 GSSTFGKSLR-----KSAAQTSPASSEITTTTTAPTTDPKKPSHKQMFKTAAVINIQQQVAQE-- 1562
                  ::||     :...|.|...|.:.......:...::|.........|.:.||:::||:
Human  1761 ------EALRLPAGHEDGVQLSWDLSPLGEVLGRDSDSSQEPFDVSDQSPGAFVAIQEELAQQLK 1819

  Fly  1563 EKA 1565
            |||
Human  1820 EKA 1822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942	51/146 (35%)
		PH	85..185	CDD:278594	37/100 (37%)
		PH_M-RIP	509..613	CDD:270094	36/123 (29%)
		PH	509..603	CDD:278594	33/105 (31%)
		SbcC	726..1353	CDD:223496	175/858 (20%)
MPRIP	XP_011522064.1	PH_RIP	48..183	CDD:269942	53/145 (37%)
		PH	76..177	CDD:278594	37/100 (37%)
		PH_M-RIP	540..641	CDD:270094	33/105 (31%)
		PH	540..633	CDD:278594	33/97 (34%)
		Lebercilin	885..1036	CDD:292252	42/169 (25%)
		BAR	<928..1117	CDD:299863	51/221 (23%)
		DUF4795	1048..1191	CDD:292662	34/171 (20%)
		CENP-F_leu_zip	1062..1190	CDD:287450	32/156 (21%)
		CDC37_N	<2118..2217	CDD:296150
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144562
Domainoid	1	1.000	84	1.000	Domainoid score	I8301
eggNOG	1	0.900	-	-		E1_KOG4807
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3371
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002350
OrthoInspector	1	1.000	-	-		otm42014
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR17271
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3300
SonicParanoid	1	1.000	-	-		X3426
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.880