DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and PLEKHA6

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	XP_006711275.1	Gene:	PLEKHA6 / 22874	HGNCID:	17053	Length:	1301	Species:	Homo sapiens

Alignment Length:	1435	Identity:	261/1435 - (18%)
Similarity:	447/1435 - (31%)	Gaps:	534/1435 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 LTLSTKLGNRHSSYHKDTLTSSQSAGNLLSS--LDLGPSSTKTAGSP-----------LTTTQSA 269
            |..|...|.|...    |..||..||.:|.|  |.|.||.:.....|           .|.:|||
Human     3 LRFSVSAGARREL----TPESSWKAGGILESQALSLSPSFSWAVHPPPSAAFSDQKYCFTPSQSA 63

  Fly   270 LADDEEDDGVETGEDVDEDEEDETSVPRKSKTVSMGGQDENNRNAGNEITNRVSQPTTCLLIEDI 334
            :...      :.|.|:                  ..|.....||.
Human    64 VCVS------QLGPDI------------------WHGSHNERRNT-------------------- 84

  Fly   335 RRDEKTIKDIANTITNLSQQQNKRWSTAVNNALNNQHHFGHHSQYQVTSRDETDFQMSSNSSSTK 399
                     ..:.:|....::||::                            |.::|:...|.|
Human    85 ---------FLHPVTGQVPEENKKF----------------------------DLKISTLDMSNK 112

  Fly   400 SQNPASERPKSLPLASNS---TPAIVSAIVKKIPTVMEQGDKTKPTARLQLHLKSPKHYQHERGD 461
            :   ..:||.:    :||   ...:||.:..:.|:|     :...|||..:
Human   113 T---GGKRPAT----TNSDIPNHNMVSEVPPERPSV-----RATRTARKAV-------------- 151

  Fly   462 PDGGCNLDELCVNYMAKTDELRSVGKANSKSSSGQGKPPVKEESLNAKKGWLMKQ-DNRTCEWSK 525
                                  :.|| .|.|.......||      .|.|||.|| .:...:|:|
Human   152 ----------------------AFGK-RSHSMKRNPNAPV------TKAGWLFKQASSGVKQWNK 187

  Fly   526 HWFTLSGAALFYYRDPLCEERGVLDGVLDVNS--LTSVIPEPAASKQHAFQLTT-W-DK------ 580
            .||.|....||||:|.  :|..:| |.:.:.|  :.:|.|....|::|.|::|. | |:
Human   188 RWFVLVDRCLFYYKDE--KEESIL-GSIPLLSFRVAAVQPSDNISRKHTFKVTVCWVDEAEASST 249

  Fly   581 ------------QRLVLASLSPSSRNSWLAVLRSAAGLPQLDTPPKQTDIEQDFIKAQLQQPSSS 633
                        :....::.||..:.:|:..:..||   ::..||.|..:.| .::...::|.|.
Human   250 RCLSPQAEHAGVRTYFFSAESPEEQEAWIQAMGEAA---RVQIPPAQKSVPQ-AVRHSHEKPDSE 310

  Fly   634 PVTP---------------------------------------------------GTPAGPHFSS 647
            .|.|                                                   |.||||..:|
Human   311 NVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLPAGPEPAS 375

  Fly   648 DE-----------------------EYRTASE-------------GGRRDSL------------- 663
            :.                       :|.:.|.             ||.|.|.
Human   376 EPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFPPRTNPDKIAQRK 440

  Fly   664 -------DW-----GSP-----LSPSP--PVLRSC---------------------LRNRSLASL 688
                   .|     |.|     .|||.  ||.|..                     :|..|:.|:
Human   441 SSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSM 505

  Fly   689 HKRSRSSPPSSRRSTVDSVASDELPLLVVPEEMQ-------------PTESRELKQQCETLRAEA 740
            ....|.|||.:......:..:...|...:.|..:             |:.||:.....|...|.:
Human   506 PAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASS 570

  Fly   741 SLREARMSELLATLQRTEQQ---LTARLQEQQQQLNSELTQAKQSASDLMHNLG---MQLTESQC 799
            |||...:.....::.|:..|   ..||:....:..::...:....:.|:..:..   |:.:.|..
Human   571 SLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSP 635

  Fly   800 QIKQLEDR--LAQGI-------------EENEGLYKRLR---ELQAQDHSGGAALSNLQRHKIKR 846
            :...|.||  :..|:             :.:|.|..:|:   |...|..|....|.::....::.
Human   636 KYDYLGDRRPVPAGLFPYNYPPSPTVHDKMDELLDLQLQRNLEYLDQQMSESETLISMVNRMVEN 700

  Fly   847 MDSLSDLTTISDIDPYC-LQRDSLAE----------------EYNELRSRFEKAVNEIRAMKREL 894
            ....|.|  ...:.||. :.||||..                |.|::....::.|.::||.|..|
Human   701 SSPRSQL--FMQVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESL 763

  Fly   895 KQS-QNQYDALEL--AQAALQQKLERRQHEDGAQLQLMAARIQ---------DLTLKYSSSERQV 947
            :.: ...:..||:  :|.|..:||  |..:|..|.||:..|::         :.|::|...|.:|
Human   764 ESALMGTHQELEMFGSQPAYPEKL--RHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEV 826

  Fly   948 RALKQKLAKSERRRSLSLKGKEQLELKLSELQRE---------------------TVERKEGTPP 991
            .||...|.:       .|....|.|:...::|:|                     |.:.:.|..|
Human   827 SALHDDLWE-------QLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGP 884

  Fly   992 ESSSSESSSQSPLNAHLLQRLHSLEHVLLGS----------------KERLEQSLTQLQQ----- 1035
            .::.|.:|..|||::..|....|...::.||                :..|.::...|:.
Human   885 SATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEEPGPPRPPLPKAYVPLESPPAVP 949

  Fly  1036 -----------------IRAGQRTRRSVSPMN---DRKDGLRQLERALAETCVMVSEQMELTCLQ 1080
                             .|:|: |.|.....|   .:||..:.|.........:|..:.|:
Human   950 PLPSESRFWPYPSSPSWHRSGE-TARGQPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEV---- 1009

  Fly  1081 DSCHKCCDLRQRVEKLSALQQ--------QTETDLQRSEQLLEQRE-TDLAQALEKCASQEQEQE 1136
                       ..||.:||.:        ::.||.:.:...:.:|. :.|...|.  :.||:.:.
Human  1010 -----------EAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLS--SQQERPKS 1061

  Fly  1137 LLLQQRQELSEELGRQQERCRRLEKRLELLEREHGKQLECLREVYHTEHANAADEQSFRKRY--- 1198
            .:.....::...:..|.:|.||.:.. .:.|:....||.          |:.|.:.|.|..|
Human  1062 AVFPGEGKVKMSVEEQIDRMRRHQSG-SMREKRRSLQLP----------ASPAPDPSPRPAYKVV 1115

  Fly  1199 -------QTEIEQLRTLC---EKGLSAMETSHKRLT----MDLEQKH-KMEIERLLAEKETALAE 1248
                   :.:|..|....   |.|..|.||..:.:.    |:||.:| .::|.:.|:..:..|..
Human  1116 RRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIP 1180

  Fly  1249 ETQATLAALDAMRKAHQSEVQREVARFKQEFLRQVQRGEQMRGDG----------AKLKEEDLGE 1303
            |....|.....:......|.|::|.|.|....:...:.....|:|          ::|:|:   |
Human  1181 ERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQ---E 1242

  Fly  1304 LRMEI 1308
            .|:||
Human  1243 KRIEI 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942
		PH	85..185	CDD:278594
		PH_M-RIP	509..613	CDD:270094	33/126 (26%)
		PH	509..603	CDD:278594	31/116 (27%)
		SbcC	726..1353	CDD:223496	140/735 (19%)
PLEKHA6	XP_006711275.1	PH_PEPP1_2_3	162..285	CDD:270068	33/131 (25%)
PLEKHA6	XP_006711275.1	PH	168..286	CDD:278594	34/129 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910