Protein Alignment osp and F10G8.8

DIOPT Version :9

• Sequence 1: NP_001162975.1
• Gene: osp / 34850
• FlyBaseID: FBgn0003016
• Length: 1566
• Species: Drosophila melanogaster
• Sequence 2: NP_001122450.1
• Gene: F10G8.8 / 172870
• WormBaseID: WBGene00008666
• Length: 984
• Species: Caenorhabditis elegans
• Alignment Length: 1439
• Identity: 314/1439 - (21%)
• Similarity: 498/1439 - (34%)
• Gaps: 563/1439 - (39%)

  Fly    38 DCRKFTPNIFNKSKCSHCFRQREEHSAAALECNRRTSSNLAEPASRKVSKCGYLFVA-PDWDFSN 101
            ||::|..||||..||..|::.::.||:.::| |.:        .:|||:.||:|:|| |:.|||.
 Worm     3 DCKRFEANIFNNGKCKICYKSKQNHSSESIE-NAK--------MNRKVTACGFLYVAPPNLDFSM 58

  Fly   102 PLYRTKRWQRRWFVLYDDGELTYSVDDYPETIPQACVDMTKVLEVTSAVEVTGHPNSIAI----T 162
            ..:..||||||||.|:|.|:|||::|:..:|:||..:||:....|:.|..:||:.:||.:    |
 Worm    59 QSHSAKRWQRRWFTLFDSGDLTYAIDNSMDTLPQLSIDMSLCYRVSEAHAITGNAHSILLAFNKT 123

  Fly   163 APER--VTFVKGTSSEESQWWLNILAAFPKSKGRHKRSATLPGGQVVGSLRPTSNG--DLTLSTK 223
            ..::  :.::|..::||.:||.|.|:.:..|:..              ::||...|  :|.:|..
 Worm   124 REDQPSIIYIKADTTEEIRWWQNGLSKYANSQNI--------------TIRPPRRGIDELPMSED 174

  Fly   224 LGNRHSSYHKDTLTSSQSAGNLLSSLDLGPSSTKT-AGSPLTTTQSALADDEEDDGVETGEDVDE 287
            :       .||.                 ||.|.: ..||:    ..|..|...:|.|....|
 Worm   175 I-------MKDV-----------------PSCTSSRCSSPV----ERLEVDRMIEGKELRGSV-- 209

  Fly   288 DEEDETSVPRKSKTVSMGGQDENNRNAGNEITNRVSQPTTCLLIEDIRRDEKTIKDIANTITNLS 352
                 .||.::|                                   .||||  ||..:.|...|
 Worm   210 -----RSVKQRS-----------------------------------IRDEK--KDFEDPIVAPS 232

  Fly   353 QQQNKRWSTAVNNALNNQHHFGHHSQYQVTSRDETDFQMSSNSSSTKSQNPASERPKSLPLASNS 417
            .      ..|.:|.|.|.                                |....|.|.......
 Worm   233 V------LPATSNVLINV--------------------------------PVDTCPVSPSCQEEP 259

  Fly   418 TPAIV--SAIVKKIPTVMEQGDKTKPTARLQLHLKSPKHYQHERGDPDGGCNLDELCVNYMAKTD 480
            ||...  ||..   ||:     .|.||.:|                     |:|      |:...
 Worm   260 TPTSTTNSATT---PTI-----STTPTQKL---------------------NID------MSNVH 289

  Fly   481 ELRSVGKANSKSSSGQGKPPVKEESLNAKKGWLM---KQDNRTCEWSKHWFTLSGAALFYYRDPL 542
            .||                          |||||   |.||   :|.|||..|:|..|..|:|..
 Worm   290 TLR--------------------------KGWLMLRGKSDN---DWCKHWVVLAGLQLKLYKDVW 325

  Fly   543 CEERGVLDGVLDVNSLTSVIPEPAASKQHAFQLTTWDKQRLVLASLSPSSRNSWLAVLRSAAGLP 607
            .|:.......:|::...:|.|. |:::.:..::.. .:.|.||::::|..|:||::.|:.....|
 Worm   326 AEDSTEPLLTVDLSQCENVYPS-ASARNYGIEIKC-RRTRYVLSAMTPGIRDSWVSALQQNRHHP 388

  Fly   608 QLDTPPKQTDI----------EQDFIKAQLQQPSSSPVTPGTPAGPHFSS---DEEYRTA---SE 656
            .    |..|:.          ..|.:...:::...:.|.|.:    |.|:   ||...|.   .|
 Worm   389 S----PTFTETFSNDANSLADSSDILGLPVKKKHIAYVAPES----HHSNSMMDEHSSTELEDDE 445

  Fly   657 GG-------RRDSLDWGSPLSPSPPVLRSCLRNRSLASLHKRSRSSPPSSRRSTVDSVASDELPL 714
            ||       ||.|...||..|.|...     |.|.      |..|..||.|||.|
 Worm   446 GGHNTNTARRRRSRRMGSRTSESADP-----RGRG------RGESLSPSVRRSPV---------- 489

  Fly   715 LVVPEEMQPTESRELKQQCETLRAEASLREARMSELLATLQRTEQQLTARLQEQQQQLNSELT-- 777
                                          ||:.|..|.::            |:...||...
 Worm   490 ------------------------------ARVKERRADIR------------QRHASNSSAASH 512

  Fly   778 QAKQSASDLMHNLGMQLTESQCQIKQLEDRLAQGIEENEGLYKRLRELQAQDHSGGAALSNLQRH 842
            |.|.|..::...:|                .|..|..:|   .|||.|:.|       :.||:
 Worm   513 QEKPSREEIQRQIG----------------TASRISSDE---TRLRSLEQQ-------VDNLR-- 549

  Fly   843 KIKRMDSLSDLTTISDIDPYCLQRDSLAEEYNELRSRFEKAVNEIRAMKRELKQSQNQYDALELA 907
              .::|:..|       |....:||::.:|..|||...:.:.:|:...::|:       |.|
 Worm   550 --TQLDAAKD-------DSARRKRDAINQEIKELRITLKSSEDELHRYRKEV-------DTL--- 595

  Fly   908 QAALQQKLERRQHEDGAQLQLMAARIQDLTLKYSSSERQVRALKQKLAKSERRRSLSLKGKEQLE 972
                     |||         ::...|.:||             |:...|..|..||
 Worm   596 ---------RRQ---------ISQNSQTVTL-------------QRAVLSTLRTQLS-------- 621

  Fly   973 LKLSELQRETVERKEGTPPESSSSESSSQSPLNAHLLQRLHSLEHVLLGSKERLEQSLTQLQQIR 1037
             .||.|.|                     |.|....:....||:::|    :|:...|.
 Worm   622 -ALSSLLR---------------------SSLFLGAVDLFDSLDNIL----DRISVDLN------ 654

  Fly  1038 AGQRTRRSVSPMNDRKDGLRQLERALAETCVMVSEQMELTCLQDSCHKCCDLRQRVEKLSALQQQ 1102
                       :...:|.||:    .||....||..:.:..|.||                   .
 Worm   655 -----------LEQTEDVLRK----TAELFEKVSSAVTIPYLSDS-------------------W 685

  Fly  1103 TETDLQRSEQLLEQRETDLAQALEKCASQEQEQELLLQQRQELSEELGRQQERCRRLEKRLELL- 1166
            |.|:.::     |.||.         ..::..:|.:.:.|:..:.|:...:.:|   |:||.:|
 Worm   686 TMTEPEK-----EPRER---------TPEDVVEETIREIRRNHTSEVESIKSQC---EQRLAVLK 733

  Fly  1167 ---EREHGKQLECLREVYHTEHANAADEQSFRKRYQTEIEQLRTLCEKGLSAMETSHKRLTMDLE 1228
               |||.|:                      ||:.|.::....|..::.:|:::||..::..:..
 Worm   734 ERAEREEGR----------------------RKKLQEQLVMASTRSDESISSVKTSFSQMLAEQR 776

  Fly  1229 QKHKMEIERLLAEKETALAEETQATLAALDAMRKAHQSEVQREVARFKQEFLRQVQRGEQMRGDG 1293
            :....|::.:..|.|..|.||..||..||:|:|:||:.|::....:.|        .||   |:.
 Worm   777 KTFDEELDCVKKEHEERLMEEKHATRLALEAVRRAHEEELKNVAEKNK--------TGE---GNH 830

  Fly  1294 AKLKEEDLGELRMEILAFSEKYSIKCVENAALEE-------------KLHMANSKLR-------- 1337
            ...:.|...|:|.|::.....||.||:||:.|:|             :|.:.|.|||
 Worm   831 IGRQSEIFDEMREELINVCALYSAKCLENSQLDEQLSNLISEKEASVELSIENDKLRSEIDRKSK 895

  Fly  1338 ----------HFQQMQQLEL--------------RNKQFRAHLASD--DPSNDVHFVQGLTSDAR 1376
                      :::::.|...              |.||.:.:...|  ..||.|...|.|..|||
 Worm   896 EIGDLQRKMNNYEKLSQSRTDPEVLAGTTVSRARREKQKKRNRRHDVRFHSNPVEIPQNLIEDAR 960

  Fly  1377 EDADCEDSE 1385
            ...|...||
 Worm   961 RALDVPVSE 969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942	54/149 (36%)
		PH	85..185	CDD:278594	43/106 (41%)
		PH_M-RIP	509..613	CDD:270094	31/106 (29%)
		PH	509..603	CDD:278594	30/96 (31%)
		SbcC	726..1353	CDD:223496	130/677 (19%)
F10G8.8	NP_001122450.1	PH_RIP	13..154	CDD:269942	54/149 (36%)
		PH	60..144	CDD:278594	30/83 (36%)
		PH_M-RIP	292..394	CDD:270094	33/136 (24%)
		PH	292..383	CDD:278594	31/121 (26%)
		MIT_CorA-like	<511..>674	CDD:294313	55/295 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159795
Domainoid	1	1.000	76	1.000	Domainoid score	I5853
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I2460
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002350
OrthoInspector	1	1.000	-	-		oto19996
orthoMCL	1	0.900	-	-		OOG6_119430
Panther	1	1.100	-	-	LDO	PTHR17271
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3300
SonicParanoid	1	1.000	-	-		X3426
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.920