DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and PLEKHA7

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens

Alignment Length:	974	Identity:	206/974 - (21%)
Similarity:	350/974 - (35%)	Gaps:	243/974 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 HFGHHSQ------YQVT---SRDETDFQMSSNSSSTKSQNPASERPKSLPLASNSTPAIVSAIVK 427
            :|..|:|      :.||   |.:.::|.:....:...|:...::||.|: ::..||....|.:
Human    71 YFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSM-VSETSTAGTASTL-- 132

  Fly   428 KIPTVMEQGDKTKPTARLQLHLKSPKHYQHERGDPDGGCNLDELCVNYMAKTDELRSVGKANSKS 492
                      :.||..::   :||                           :.::.|.||.:...
Human   133 ----------EAKPGPKI---IKS---------------------------SSKVHSFGKRDQAI 157

  Fly   493 SSGQGKPPVKEESLNAKKGWLMKQDNRTCE-WSKHWFTLSGAALFYYRDPLCEERGVLDGV-LDV 555
            ......|.|       .:|||.|||:.... |.:.||.|:...||||:|  ..|..||..: |..
Human   158 RRNPNVPVV-------VRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKD--SREEAVLGSIPLPS 213

  Fly   556 NSLTSVIPEPAASKQHAFQLTTWDKQRLVLASLSPSSR-------------------NSWLAVLR 601
            ..::.|.||...|::::|:......:.|:..|.:..|:                   |:|:..:.
Human   214 YVISPVAPEDRISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMN 278

  Fly   602 SAAGLPQLDTPPKQTDIEQDFIKAQLQQ-PSSS---------PVTPG-TPAGPHFSSD------- 648
            .||.:      ..::.:::|..|.:.|. |.::         .|.|| |...||...|
Human   279 QAAQV------LSRSSLKRDMEKVERQAVPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFER 337

  Fly   649 -----EEYRTASE--GGRRDSLDWGSPLSPSPPVLRSCLRNRSLASLHKRSRSSPPSSRRSTVDS 706
                 |:||:..:  .|:||.....||.||:.       .:.....|....|......:|:..:.
Human   338 QEQEGEQYRSQRDPLEGKRDRSKARSPYSPAE-------EDALFMDLPTGPRGQQAQPQRAEKNG 395

  Fly   707 VASDELPLLVVPEEM--------------QPTESRELKQQCETLR--AEASLREARMSELLATLQ 755
            :    ||....|.|.              .|.:..:.|.....:.  |.|...::|...|..||.
Human   396 M----LPASYGPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLP 456

  Fly   756 RTEQQLTARLQEQQQQLNSELTQAKQSASDLMHNLGMQLTESQCQIKQL----EDRLAQGIEENE 816
            |.....:....|..|.|..........:|....||......:|.:...|    |:|.|    ..:
Human   457 RQGPGQSLSFPENYQTLPKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRA----HRD 517

  Fly   817 GLYKRLRELQAQDHSGGAALSNLQRHKIKRMDSLSDLTTISDIDPYCLQRDSLAEEYNELRSRFE 881
            |...:|.|.|             ||.:.:..         |...|.||......:: ...||..|
Human   518 GTVWQLYEWQ-------------QRQQFRHG---------SPTAPICLGSPEFTDQ-GRSRSMLE 559

  Fly   882 KAVNEIRAMKRELKQSQNQYDALELAQAALQQKLERRQHEDGAQLQLM---AARIQDLTLKYSSS 943
                    :.|.:....:..|........:..  .||.|....::.:.   ..|..|::|  ..|
Human   560 --------VPRSISVPPSPSDIPPPGPPRVFP--PRRPHTPAERVTVKPPDQRRSVDISL--GDS 612

  Fly   944 ERQVRALKQKLAKSERRRSL-------------SLKGK--EQLELKLSELQRETVERKEGTPPES 993
            .|:.|....|.:....|||:             ||.||  |:|.|.|:.|:|...        :.
Human   613 PRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSLEELSLLLTRLRRHQA--------KL 669

  Fly   994 SSSESSSQSPLNAH------------LLQRLHSLEHVLLGSK--ERLEQSLTQ-LQQIRAGQRTR 1043
            :|..:.:.|.|..|            .||....||::.|..|  |.|...|.: |::...|.|.|
Human   670 ASVRNFAISQLLQHQLTFPTCQADDTYLQLKKDLEYLDLKIKNNEPLINVLYKVLKKSARGCRPR 734

  Fly  1044 RSVSPMNDRKD-GLRQLERALAETCVMVSEQMELTCLQDSCHKCCDLRQRVEKLSALQQQTETDL 1107
            ||::..:..|| .|:.::.|.::|.|.:|    :.|.||...:  ||..::..|...:.|.|:.|
Human   735 RSMTGRDLLKDRSLKPVKIAESDTDVKLS----IFCEQDRVLQ--DLEDKIRALKENKDQLESVL 793

  Fly  1108 QRSEQLLEQRETDLAQALEKCASQEQ-EQELLLQQRQELSEELGRQQERCRRLEKRLELLEREHG 1171
            :...:.:||.. |..|.|||.|.|:: .||.|:..|.|||.|....:....      |.|:.|:
Human   794 EVLHRQMEQYR-DQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWN------EYLKLEN- 850

  Fly  1172 KQLECLREVYHTEHANAADEQSFRKRYQTEIEQLRTLCEKGLSAMETSHKRLTMDLEQKHKMEI 1235
             .:|.|::....:|..|...|. :.:.|.::.::..: ..||||.:.:.:.|...::...:..:
Human   851 -DVEQLKQTLQEQHRRAFFFQE-KSQIQKDLWRIEDV-TAGLSANKENFRILVESVKNPERKTV 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942
		PH	85..185	CDD:278594
		PH_M-RIP	509..613	CDD:270094	31/124 (25%)
		PH	509..603	CDD:278594	29/114 (25%)
		SbcC	726..1353	CDD:223496	123/551 (22%)
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827
		WW	56..85	CDD:306827	3/13 (23%)
		PH_PEPP1_2_3	159..281	CDD:270068	31/130 (24%)
		NESP55	<299..460	CDD:115071	35/171 (20%)
		DUF1640	779..905	CDD:311647	35/136 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910