DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and PLEKHH2

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	NP_742066.2	Gene:	PLEKHH2 / 130271	HGNCID:	30506	Length:	1493	Species:	Homo sapiens

Alignment Length:	1270	Identity:	243/1270 - (19%)
Similarity:	423/1270 - (33%)	Gaps:	357/1270 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 EEHSAAALECNRRTSSNLAEPASRKVSKCG------YLFVAPDWD--FSNPLYRTKR-------- 108
            :|...:......|.:|.|:...|.:..:|.      ||..:.|..  |....:..||
Human   289 DEEDGSKGRSKSRCTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYS 353

  Fly   109 WQR--RWFVLYDDGELTYSVDDYPETIPQACVDMTKVLEVTSAVEVTGHPNSIAITAPERVTFVK 171
            ||:  :|..|             ...:.:...:::|..:.:|:.|:.....|      :|:.:
Human   354 WQQEAQWKAL-------------NSPLGKGNSELSKKEQDSSSDELNKKFQS------QRLDY-- 397

  Fly   172 GTSSEESQWWLNIL--AAFPKSKGRHKRSATLPGGQVVGSLRPTSN---------GDLTLSTKLG 225
            .:||.|:.....||  |..||    |..|.:..|.|:|    |:|:         ...::|..|.
Human   398 SSSSSEANTPSPILTPALMPK----HPNSLSGKGTQLV----PSSHLPPPKLRIPNVFSISVALA 454

  Fly   226 NRHSSYHKDTLTSSQSAG---NLLSSL-DLGPSSTK---TAGSPLTTTQSALADDEEDDGVETGE 283
            .||.|  :..|:|.:..|   |.:|.: .|.|..|.   ..|......::  .|...|||:.:.:
Human   455 KRHLS--QPQLSSDRMFGTNRNAISMIRPLRPQETDLDLVDGDSTEVLEN--MDTSCDDGLFSYD 515

  Fly   284 DVDEDEEDETSVPRKSKTVSMGGQDENNRNAGNEITNRVSQPTTCLLIEDIRRD---EKTIKDIA 345
            .:|....|:......:|.|:                  .|:|.|    ..:.|.   |..|..:|
Human   516 SLDSPNSDDQEHCDSAKKVA------------------YSKPPT----PPLHRFPSWESRIYAVA 558

  Fly   346 NTITNLSQQQN-------------------------KRWSTAVNNALNNQHHFGHHSQYQVTSRD 385
            .:...:|:..|                         |..:|.|...|..          :.|...
Human   559 KSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTPVYTTLKG----------KATQIS 613

  Fly   386 ETDFQMSSNSSSTKSQNPASERPKSLPLASNSTPAIVSAIVKKIPTVMEQGDKTKPTARLQLHLK 450
            .:.|...|:.|..:..:.:|.|.......|.|.|.        .|..|::|......|....:..
Human   614 SSPFLDDSSGSEEEDSSRSSSRTSESDSRSRSGPG--------SPRAMKRGVSLSSVASESDYAI 670

  Fly   451 SPKHY--QHERGDPDGGCNLDELCVNYMAKTDELRSVGKANSKSSSGQGKPPVKEESLNAKKGWL 513
            .|..|  ..|...|:.  .|.:.|                :|.|.:|:.:|       ..|.|:|
Human   671 PPDAYSTDTEYSQPEQ--KLPKTC----------------SSSSDNGKNEP-------LEKSGYL 710

  Fly   514 MKQDNRTCEWSKHWFTLSGAALFYYRDPLCEERGVL---DGVLDVNSLTSVIPEPAASKQHAFQL 575
            :|...:...|.:.||.|.|..|.||:.|    ..|:   .|.:::::..|::   ....:...||
Human   711 LKMSGKVKSWKRRWFVLKGGELLYYKSP----SDVIRKPQGHIELSASCSIL---RGDNKQTVQL 768

  Fly   576 TTWDKQRLVLASLSPSSRNSWLAVLRSAAGLPQLDTPPKQTDIEQDFIKAQLQ-----QPSSSPV 635
            || :|....|.:.||:....|:.||                   |:.::.|..     ||...|.
Human   769 TT-EKHTYYLTADSPNILEEWIKVL-------------------QNVLRVQAANPLSLQPEGKPT 813

  Fly   636 TPGTPAGPHFSSDEEYRTASEGGRRDSLDWGSPLSPSPPVLRSCLRNRSLASLHKRSRSSPPSSR 700
            ..|            ..|..:.|....: |.:.:..:....||
Human   814 MKG------------LLTKVKHGYSKRV-WCTLIGKTLYYFRS---------------------- 843

  Fly   701 RSTVDSVASDELPLLVVPEEMQPTESRELKQQCETLR-AEASLREARMSELLATLQRTEQQLTAR 764
                   ..|:.||..:  ::...:..|:.:.|::.. .|||.|....:.....:...:|..|..
Human   844 -------QEDKFPLGQI--KLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYL 899

  Fly   765 LQEQQQQLNSELTQAKQSASDLMHNLGMQLTESQCQIKQLEDRLAQGI-------EENEGLYKRL 822
            |...:.:.::.|.....:|.....|:|.:..:..|::..::...:..|       ...||:...|
Human   900 LIGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGIISPL 964

  Fly   823 RELQAQDHSGGAALSNLQRHKIKRMDSLSDLTTISDIDPYCLQRDSLAEEYNELRSRFEKAVNEI 887
            ..|.::         .||...||...:.......:...|......|||:...::.....:..|||
Human   965 TTLPSE---------ALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEI 1020

  Fly   888 --RAMKR-ELKQSQNQYDALELAQ-AALQQKLERRQHEDGAQLQLMAARIQDLTLKYSS----SE 944
              :.:|: ..:|.|||...|:..| .||...|....|.....|:|...|..|...::..    .:
Human  1021 CCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKYAIYCQ 1085

  Fly   945 RQVRALKQKLAKSERRRSLSLKGKEQLELKLSELQRETVERKEGTPPESSSSESSSQSPLNAHLL 1009
            |.|...:|. ...|.|.|       ::|: ||.|.|.         |...|...|    :..|.:
Human  1086 RCVERTQQN-GDREARPS-------RMEI-LSTLLRN---------PYHHSLPFS----IPVHFM 1128

  Fly  1010 QRLHSLEHVLLGSKERLEQSLTQLQQIRAGQRTRRS-VSPMNDRKDGLRQLERALAETCVMVSEQ 1073
            ..::.:  |...:...:|:.|..|.|....::..:| .:...|...| |.||.
Human  1129 NGIYQV--VGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSG-RDLEH------------ 1178

  Fly  1074 MELTCLQDSCHKCCDLRQRVEKLSALQQQTETDLQRSEQLLEQRETDLAQALEKCASQEQEQELL 1138
                |||.:. |.||:..:.|:.|..||..:.:..|:.:|..:..  |..:::.....::|:.||
Human  1179 ----CLQGNI-KICDIISKWEQASKEQQPGKCEGTRTVRLTYKNR--LYFSVQARGETDREKLLL 1236

  Fly  1139 LQQRQE--------LSEELGRQQERCRRLEKRLELLEREHG-----------------KQLECLR 1178
            :.|..:        |:::|.        ||....|.:.|.|                 |..:.|:
Human  1237 MYQTNDQIINGLFPLNKDLA--------LEMAALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLK 1293

  Fly  1179 EVYHTEHANAADEQSFRKRYQ--TEIEQLRTLCEK 1211
            :|.         |:.:.|||:  ...||||.||::
Human  1294 QVI---------EKFYPKRYRDGCSEEQLRQLCQR 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942	28/150 (19%)
		PH	85..185	CDD:278594	19/117 (16%)
		PH_M-RIP	509..613	CDD:270094	27/106 (25%)
		PH	509..603	CDD:278594	27/96 (28%)
		SbcC	726..1353	CDD:223496	108/530 (20%)
PLEKHH2	NP_742066.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..230
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..335		9/45 (20%)
		Agro_virD5	<322..>410	CDD:129031	18/108 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..439		21/104 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..705		22/124 (18%)
		PH	704..797	CDD:278594	28/119 (24%)
		PH1_PLEKHH1_PLEKHH2	706..801	CDD:241436	29/121 (24%)
		PH	812..914	CDD:278594	20/145 (14%)
		PH	812..914	CDD:214574	20/145 (14%)
		MyTH4	955..1110	CDD:214535	39/172 (23%)
		B41	1123..1354	CDD:214604	49/236 (21%)
		FERM_M	1229..1354	CDD:278785	24/108 (22%)
		FERM_C-lobe_PLEKHH1_PLEKHH2	1350..1449	CDD:241360
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1474..1493
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910