DRSC/TRiP Functional Genomics Resources

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Protein Alignment osp and TRIOBP

DIOPT Version :9

Sequence 1:NP_001162975.1 Gene:osp / 34850 FlyBaseID:FBgn0003016 Length:1566 Species:Drosophila melanogaster
Sequence 2:NP_001034230.1 Gene:TRIOBP / 11078 HGNCID:17009 Length:2365 Species:Homo sapiens


Alignment Length:1225 Identity:272/1225 - (22%)
Similarity:425/1225 - (34%) Gaps:459/1225 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 GHPNSIAITAPERVTFVKGTSSEESQWWLNILAAFPKSKGRHKRSATLPGGQVVGSLRPTSNGDL 218
            |.|:..|..|||...  .|||.|..:.|                     |.......:||..   
Human  1463 GEPSLGAAKAPEGAW--GGTSREYKESW---------------------GQPEAWEEKPTHE--- 1501

  Fly   219 TLSTKLGNRHSSYHKDTLTS-SQSAGNLLSSLDLGPSSTKT---AGSPLTTTQSALADDEEDDGV 279
             |..:||.|      ..||| .::.|        ||:.:..   :|:|......|........|.
Human  1502 -LPRELGKR------SPLTSPPENWG--------GPAESSQSWHSGTPTAVGWGAEGACPYPRGS 1551

  Fly   280 ETGEDVD-ED-------------------------EEDETSVPRKSKTVSMGGQDENNRNAGNEI 318
            |...::| .|                         |..:..:|||...   |.:|:..|..|.|:
Human  1552 ERRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPA---GHRDDLARALGPEL 1613

  Fly   319 TNRVSQPTTCLLIEDIRRDEKTIKDIANTITNLSQQQNKRW--STAVNNALNNQHHFGHHSQYQV 381
                ..|.|    .|:...|             |..|.:.|  :|.||         ||....| 
Human  1614 ----GPPGT----NDVPEQE-------------SHSQPEGWAEATPVN---------GHSPALQ- 1647

  Fly   382 TSRDETDFQMSSNS-SSTK------SQNPASERPKSL----PLASNSTPAIVSAIVKKIPTVMEQ 435
               .::..|:.|.: :||:      ::.||:.....|    ||.|.||        .|.|::.| 
Human  1648 ---SQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRST--------AKGPSLPE- 1700

  Fly   436 GDKTKPTARLQLHLKSPKHYQHERG-DPDGGCNLDELCVNYMAKTDELRSVGKANSKSSSGQGKP 499
                     ||...:.|:..:..|| ||               .||: :....|:.:.:.|:...
Human  1701 ---------LQFQPEEPEESEPSRGQDP---------------LTDQ-KQADSADKRPAEGKAGS 1740

  Fly   500 PVK-------------------------------EESLNAKKGWLMKQD------------NRTC 521
            |:|                               .:.||.||||:...|            ..|.
Human  1741 PLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGWMSILDEPGEPPSPSLTTTSTS 1805

  Fly   522 EWSKHWFTLSGAALFYYRDPLCEERGVLDGVLDVNSLTSVIPEPAASKQHAFQLTTWDKQRLVLA 586
            :|.||||.|:.::|.||||...||...|||.:|:.|.|.| .|.|..:.:.||:.|.|.. ..|:
Human  1806 QWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDV-TEYAVQRNYGFQIHTKDAV-YTLS 1868

  Fly   587 SLSPSSRNSWLAVLR------SAAGLPQLDTPPKQTDI-----EQDFIKAQLQQPSSSPVTPGTP 640
            :::...|.:|:..||      ||..:.:|....|:..:     ::..:||..|:..|..::.|.|
Human  1869 AMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGP 1933

  Fly   641 AGPHFSSDEEYRTASEGGRRDSLDWG--SPLSPSPPVLRSCLRNRSLASLHKRSRSSPPSSRRST 703
                       |.|.  |:|.:||:.  |||:.:.|                 .|:..|:   .|
Human  1934 -----------RKAD--GQRQALDYVELSPLTQASP-----------------QRARTPA---RT 1965

  Fly   704 VDSVASDELPLLVVPEEMQPTESRELKQQCETLRAEASLREARMSELLATLQRTEQQLTARLQEQ 768
            .|.:|..        ||::    |:|.|:.|..|......::|..|:.|                
Human  1966 PDRLAKQ--------EELE----RDLAQRSEERRKWFEATDSRTPEVPA---------------- 2002

  Fly   769 QQQLNSELTQAKQSASDLMHNLGMQLTESQCQIKQLEDRLAQGIEENEGLYKRLRELQAQDHSGG 833
                          .......||..|||.|      ::||::.||      |:.:||:       
Human  2003 --------------GEGPRRGLGAPLTEDQ------QNRLSEEIE------KKWQELE------- 2034

  Fly   834 AALSNLQRHKIKRMDSLSDLTTISDIDPYCLQRDSLAEEYNELRSRFEKAVNEIRAMKRELKQSQ 898
                .|...:.||:    .||        .|...|..|.........|....|::|::.:|:..:
Human  2035 ----KLPLRENKRV----PLT--------ALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWR 2083

  Fly   899 NQYDALELAQAALQQKLERRQHEDGAQLQLMAARIQDLTLKYSSSERQVRALKQKLAKSERRRSL 963
            .|.:|   .|:||      |..|||           .:...|.|.|    |.::.||:.|   |.
Human  2084 LQGEA---PQSAL------RSQEDG-----------HIPPGYISQE----ACERSLAEME---SS 2121

  Fly   964 SLKGKEQL----ELKLSELQRETVERKEGTPPESSSSESSSQSPLNAHLLQRLHSLEHVLLGSKE 1024
            ..:..|:|    |.:|..||:|    ||....|.:::.:|              ::|.:....:|
Human  2122 HQQVMEELQRHHERELQRLQQE----KEWLLAEETAATAS--------------AIEAMKKAYQE 2168

  Fly  1025 RLEQSLTQLQQIRAGQRTRRSVSPMNDRKDGLRQLER----ALAETCVMVSEQMELTCLQDSCHK 1085
            .|.:.|::.:.::.|             .||||:..:    ||.....::|||....||:     
Human  2169 ELSRELSKTRSLQQG-------------PDGLRKQHQSDVEALKRELQVLSEQYSQKCLE----- 2215

  Fly  1086 CCDLRQRVEKLSALQQQTETDLQRSEQLLEQRETDLAQALEKCASQEQEQELLLQQRQE----LS 1146
                      :.||.:|.           |:||    ..|.:|   :||.:.||:..||    ||
Human  2216 ----------IGALMRQA-----------EERE----HTLRRC---QQEGQELLRHNQELHGRLS 2252

  Fly  1147 EEL----------------GRQQER--CRRLEKRLELLERE---HGKQLECLREVYHTEHANAAD 1190
            ||:                ||..||  | .||..|.:.|.|   ..|:::|||:......   .|
Human  2253 EEIDQLRGFIASQGMGNGCGRSNERSSC-ELEVLLRVKENELQYLKKEVQCLRDELQMMQ---KD 2313

  Fly  1191 EQSFRKRYQ---TEIEQLRTLCEKGLSAMETSHKRLTM-DLEQKHKMEIERLLAE 1241
            ::....:||   .|:..::|..|:.:..:: .|.||.| .|::|..|  ...|||
Human  2314 KRFTSGKYQDVYVELSHIKTRSEREIEQLK-EHLRLAMAALQEKESM--RNSLAE 2365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ospNP_001162975.1 PH_RIP 48..191 CDD:269942 11/36 (31%)
PH 85..185 CDD:278594 11/30 (37%)
PH_M-RIP 509..613 CDD:270094 40/121 (33%)
PH 509..603 CDD:278594 37/111 (33%)
SbcC 726..1353 CDD:223496 125/553 (23%)
TRIOBPNP_001034230.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 48..1106
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1168..1554 29/131 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1593..1667 25/110 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1679..1751 22/105 (21%)
PH_M-RIP 1781..1895 CDD:270094 39/115 (34%)
PH 1781..1887 CDD:278594 37/107 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1889..2017 39/202 (19%)
BAR <2065..2145 CDD:299863 28/110 (25%)
CortBP2 2068..2203 CDD:286770 42/192 (22%)
GBP_C <2107..2205 CDD:303769 29/135 (21%)
DUF3585 <2159..2309 CDD:304905 48/196 (24%)
coiled coil 2173..2186 CDD:293879 2/25 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2174..2194 6/32 (19%)
coiled coil 2195..2205 CDD:293879 2/9 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144561
Domainoid 1 1.000 65 1.000 Domainoid score I10048
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 238 1.000 Inparanoid score I3371
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002350
OrthoInspector 1 1.000 - - otm42014
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR17271
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3300
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
77.110

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