DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment osp and acap3

DIOPT Version :9

Sequence 1:	NP_001162975.1	Gene:	osp / 34850	FlyBaseID:	FBgn0003016	Length:	1566	Species:	Drosophila melanogaster
Sequence 2:	XP_012821390.1	Gene:	acap3 / 100127680	XenbaseID:	XB-GENE-1013301	Length:	871	Species:	Xenopus tropicalis

Alignment Length:	829	Identity:	147/829 - (17%)
Similarity:	260/829 - (31%)	Gaps:	283/829 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   806 DRLAQGIEENEGLYKRLRELQAQDHSGGAALSNLQRHKIKRMDSLSDLTTISDIDPYCLQR--DS 868
            |.:...:.|.|....:|.:|.:.....|.......:|.:..:..||......::...||.:  ||
Frog    20 DEVETDVVEIEAKLDKLVKLCSSMLEAGKTYLTTNKHFVSGIRDLSQQCKKDEMISECLDKFGDS 84

  Fly   869 LAEEYNELRSRFEKAVNEIRAM--------KRELKQSQNQYDA----LELAQAALQQKLERRQHE 921
            |.|..|.....|::|...:|..        .|:.|:|:.|:|.    |::|.....|....:.||
Frog    85 LQEMVNYHMILFDQAQRSVRQQLHMFVKDDVRKFKESKKQFDKVREDLDIALVKNAQAPRHKPHE 149

  Fly   922 -DGAQLQLMAAR--IQDLTLKYSSSERQVRALKQKLAKSERRRSLSLKGKEQLELKLSELQRETV 983
             :.|...|...|  .:.|.|.|   ..|:..|:.|            |..|.|:..||.:..:..
Frog   150 VEEASSTLTITRKCFRHLALDY---VLQINVLQAK------------KKFEILDAMLSFMHAQYT 199

  Fly   984 ERKEGTPPESSSSESSSQSPLNAHLLQRLHSLEHVLLGS---KERLEQSLTQLQQ---------- 1035
            ..::|         .|..:.||.::.|....|:.:::.|   |..:|.....:||
Frog   200 FFQQG---------YSLLNELNPYMKQLASELDQLVIDSAVEKREMEHKHATIQQRTLLQDFSYD 255

  Fly  1036 --------------IRAG---QRTRRSVSPMNDRKDGLR--QL--ERALAETCVMVSEQMELTCL 1079
                          :..|   :|...:....|.|...::  ||  ::.|.:...:|.|.:.| |.
Frog   256 DSKADFNVDAPNGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDVLTVVVEDLRL-CT 319

  Fly  1080 QDSCH--------------KCCDLRQRVEKL----------SALQQQTETDLQRSEQLLEQRETD 1120
            ...|.              |.|.|:...|||          |......||......:.|::..:.
Frog   320 VKPCEDIERRFCFEVVSPSKSCMLQADSEKLRQSWIQAVQASIASAYRETPDNYYIERLDRTASP 384

  Fly  1121 LAQALEKCASQEQEQ----ELLLQQRQELSE-----ELGRQQERCRRLEKRLELLEREHGKQLEC 1176
            ...:::. ||..:|:    |.:||:.|.::.     :.|:...|...:...:.|.       :||
Frog   385 STSSIDS-ASDSRERSVKGESILQRVQSIAGNDQCCDCGQTDPRWASINLGITLC-------IEC 441

  Fly  1177 L---REV-YHTEHANAADEQSFRKRYQTEIEQLRTLCEKGLSAMETSHKRLTMDLEQKHKMEIER 1237
            .   |.: .|.....:....|:      |.|.|:.:||.|.|.           :.|.::.:.|.
Frog   442 SGIHRSLGVHFSKVRSLTLDSW------EPELLKLMCELGNST-----------INQIYEAKCEH 489

  Fly  1238 LLAEKETALAEETQATLAALDAMRKAHQSEVQREVARFKQEFLRQVQRGEQMRGDGAKLKEEDLG 1302
            |..:|.|:....              ...|:..:....:::||::                  ||
Frog   490 LGLKKPTSGCSR--------------QDKEIWIKAKYVEKKFLKR------------------LG 522

  Fly  1303 ELRMEILAFSEKYSI-KCVENAALEEKLHMANSKLRHFQ------QMQQLELRNKQFR------- 1353
            .:.:|.....:::|: ||..|.: ..|:.....|.||..      .:.......::||
Frog   523 AVEVENDRKPQRWSVKKCHRNNS-TTKVPSTRRKYRHEMGSASPAMLSSAATLERKFRRDSLFCP 586

  Fly  1354 --------------------------------------------------AHLASD-------DP 1361
                                                              ..|:||       |.
Frog   587 DELDSLFSYFDTGSGPRSVNPLPAQHPLPAVPWTGSGAEPGGSAMPFLPDGGLSSDSGLGGSTDG 651

  Fly  1362 SNDVHFVQGLTSDAREDADCEDSEPAPQILGATATRTTATTTTTATATTTSAAPSETESNPDSDR 1426
            |||: .|.|...|:..:.:||.||                         .|:...|||..|....
Frog   652 SNDI-LVFGAVVDSVTEEECEVSE-------------------------DSSGEVETEQEPSDPE 690

  Fly  1427 ETAD---------SSRAPPEKMEQSLFVIPSHMLNSSLVPAANASDQSQ 1466
            :..:         :||.      ::|.|:...:.|.:.|...|..|:|:
Frog   691 DLRELHPGLLMFRASRT------RNLPVMAEALANGANVNWVNDEDESK 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942
		PH	85..185	CDD:278594
		PH_M-RIP	509..613	CDD:270094
		PH	509..603	CDD:278594
		SbcC	726..1353	CDD:223496	117/641 (18%)
acap3	XP_012821390.1	BAR_ACAP3	16..215	CDD:153321	47/218 (22%)
		PH_ACAP	271..367	CDD:270070	19/96 (20%)
		ArfGap_ACAP3	403..518	CDD:350075	25/152 (16%)
		ANKYR	<689..818	CDD:223738	9/51 (18%)
		ANK repeat	729..762	CDD:293786	2/5 (40%)
		ANK repeat	764..795	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910