DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment noc and Zfp703

DIOPT Version :9

Sequence 1:	NP_001285932.1	Gene:	noc / 34847	FlyBaseID:	FBgn0005771	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001102895.1	Gene:	Zfp703 / 680717	RGDID:	1588249	Length:	593	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	184/606 - (30%)
Similarity:	237/606 - (39%)	Gaps:	172/606 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LQPDYLAPL------PTTMDAKKSPLALLAQTCSQIGADSSAVKPLLAMDKNKTKPGACSSSSNS 77
            |.|:||.||      |..:||||||||||||||||||                 ||....||..:
  Rat    65 LHPEYLQPLSSTPVSPIELDAKKSPLALLAQTCSQIG-----------------KPDPPPSSKLN 112

  Fly    78 SSSSGSAEISAAKSPSGQAKSPKSSTP-ISSTATSASLSNTSTGEIKLAFKPYETNVLSHQNQNS 141
            |.:      :||.:..|..|.|..|.| .:|.|.:......|..|.|.:||||........::..
  Rat   113 SVA------AAAANGLGSEKDPSRSAPGAASAAAALKQLGDSPAEDKSSFKPYSKGSGGGDSRKD 171

  Fly   142 FKSSSSLDAEPTRPSSKNSSSAQERVPSRSKSNATPTDGGKAEISAHDSSSSRKTVSPSGSSQRG 206
             ..|||:.:..:..||.....|..||||.:   ..|.....|.:|...:||     ||.||  ||
  Rat   172 -GGSSSVSSTTSSSSSSPGDKAGFRVPSAA---CPPFPPHGAAVSTSSNSS-----SPGGS--RG 225

  Fly   207 ASP---IVRSGMEVLNNANGTA------QHPKEMSSMAAAAAAAAAAYKAAGPYGL------NPL 256
            .||   ..:||.   ..|.|..      |..|.....||.:..::......||...      .|.
  Rat   226 GSPHHSDCKSGS---GGAGGGGELDKKDQEAKPSPEPAAGSRGSSGDSAHGGPEATASGRKSEPP 287

  Fly   257 SAL-----CCPPGMEQHANPAF-RPPFAGGFSHHHAAMLAVAANGGYP---------------GG 300
            |||     ..|....:..:..| .||.:.|:   |.::  |.|..|||               ||
  Rat   288 SALVGAGHVAPVSPYKPGHSVFPLPPSSIGY---HGSI--VGAYAGYPSQFVPGLDPSKSGLVGG 347

  Fly   301 APGGG---PAGQPNPYISYQRIKTPAGGEA----IVPVCKDPYCQGCPYSAHTQQMLMGAPCPAG 358
            ...||   |.|:|..       .:|..|.:    :..:|:||||.|   ..|:...|.|    :.
  Rat   348 QLSGGLGLPPGKPPS-------SSPLTGASPPSFLQGLCRDPYCLG---GYHSASHLGG----SS 398

  Fly   359 CTQCE-HQKYGLAMASAAGLP---PAHPYSQAAAAAAANAAAA--------------RSAPYVCS 405
            |:.|. |...|.:: .|:|.|   |.||...||.:::|..||.              ...|:.|:
  Rat   399 CSTCSAHDPAGPSL-KASGYPLVYPGHPLQPAALSSSAAQAALPGHPLYTYGFMLQNEPLPHSCN 462

  Fly   406 WVVGDAYCGKRFQTSDELFSHLRTHT---------------GNLSDPAAAAAALAQSQAQSLLGT 455
            ||.....|.|||.||:||.|||||||               .:|...||||||.|.....
  Rat   463 WVAASGPCDKRFATSEELLSHLRTHTALPGAEKLLAAYPGASSLGSAAAAAAAAASCHLH----- 522

  Fly   456 LFPPSALRAGYPTPPLSPMSAAAAA------ARYHPYAKPPPGALAGGPSPFGAAGAFNPAAAAA 514
             .||       |..|.||.|.:..:      :|||||          |.|....||..   |..:
  Rat   523 -LPP-------PAAPGSPGSLSLRSPHTLGLSRYHPY----------GKSHLSTAGGL---AVPS 566

  Fly   515 AAALGPYYSPYAMYGQRMGAA 535
            ....||||||||:||||:.:|
  Rat   567 LPTAGPYYSPYALYGQRLASA 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
noc	NP_001285932.1	zf-C2H2	402..430	CDD:278523	15/27 (56%)
noc	NP_001285932.1	C2H2 Zn finger	404..430	CDD:275368	15/25 (60%)
Zfp703	NP_001102895.1	nlz1	314..368	CDD:289188	15/65 (23%)
Zfp703	NP_001102895.1	C2H2 Zn finger	461..487	CDD:275368	15/25 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352052
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C18X
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4245
OMA	1	1.010	-	-		QHG49654
OrthoDB	1	1.010	-	-		D1163882at2759
OrthoFinder	1	1.000	-	-		FOG0003524
OrthoInspector	1	1.000	-	-		otm45249
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12522
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.870