DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment noc and elB

DIOPT Version :9

Sequence 1:	NP_001285932.1	Gene:	noc / 34847	FlyBaseID:	FBgn0005771	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_523566.4	Gene:	elB / 34844	FlyBaseID:	FBgn0004858	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	609	Identity:	217/609 - (35%)
Similarity:	280/609 - (45%)	Gaps:	149/609 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 NNQYLQPDYL--APLPTT-MDAKKSPLALLAQTCSQIGADSSAVKPLLAMDKNKTK-----PGAC 71
            |:.||:|||:  |..||. :|.|.|||||||||||.||||::..|.|.|..:..||     |
  Fly     6 NHHYLRPDYMTAAAAPTAQLDNKSSPLALLAQTCSAIGADTTNPKLLAANIEKSTKQLQHHP--- 67

  Fly    72 SSSSNSSSSSGSAEISAAKSPSGQAKSPKSSTPISSTATSASL-------------SNTSTGEIK 123
             ..|:.|..|||..:|...|..|.|:.  .|:|:||.::|.|.             |::|:....
  Fly    68 -KGSSGSGGSGSFGLSQQASMDGSARD--KSSPVSSHSSSVSTGSVEQQQLPPAHGSSSSSKPTP 129

  Fly   124 LAFKPYETNVLSHQNQNSFKSSSSLDAEPTRPSSKNSSSAQERVPSRSKSNATPTDGGKAEISAH 188
            ..|||||      .|.|....:::.|...|..|| |::|||:||    |:..:.|:||.....::
  Fly   130 TTFKPYE------PNNNISNITTAADCGATNLSS-NNTSAQQRV----KTPKSMTNGGGQRCDSN 183

  Fly   189 DSSSSRKTVSPSGSSQRGASPIVRSGMEVLNNANGTAQH------------------PKEMSSMA 235
            .|:||:...||:.:.....:|  .||:     |.|..||                  .||.::|.
  Fly   184 QSASSQHRESPTAAGSLRRTP--TSGL-----AGGVMQHNGSPGLPPTASTTPGRSNSKESAAMH 241

  Fly   236 AAAAAAAAAYKAAGPYGLNPLSALCCPPGMEQHANPAFRPPFAGGFSHHHAAMLAVAANGGYPGG 300
            :.:||||||..||.....|.|.........|.:...|..     ..|...:|..|.||...||
  Fly   242 SPSAAAAAAAAAAQIASSNRLQEAALAAAKEANYVKALH-----AASQQGSASAAAAAASYYP-- 299

  Fly   301 APG-GGP--------------------AGQPNPYISYQRIK--TPAGGEAIVP-VCKDPYCQGCP 341
             || |.|                    |...|||::|.|:|  |.....|..| ||:||||.|||
  Fly   300 -PGYGSPYSMDLMTASSLMSPHHAMFKASAMNPYLNYARMKGLTEQSMMAATPNVCRDPYCTGCP 363

  Fly   342 YSAHTQQMLMGAPCPAGCTQCEHQKYG-----LAMASAAGLPPAHPYSQAAAAAAANA------- 394
            .|.|......|.||||||.|||....|     .:..|..|...:...:.|||||||::
  Fly   364 ASPHYINKAAGQPCPAGCPQCEGGGGGGGGSSKSSGSQGGSGGSSSAAAAAAAAAASSYHAQLAA 428

  Fly   395 -AAARSAPYVCSWVVGD-AYCGKRFQTSDELFSHLRTHTGNLSDPAAAAAALAQSQAQSLLGTLF 457
             |||...||||||:..| |||||||.|||:||.||||||.::.|...:|||...          .
  Fly   429 LAAASQMPYVCSWIGSDAAYCGKRFGTSDDLFQHLRTHTASVPDAVLSAAAAGG----------I 483

  Fly   458 PPS--ALRAGYPTPPLSPMSAAAAAARYHPYAKP--------PPGALAGGPSPFGAAGAFNPAAA 512
            ||:  ..:..||||||||:|    |||||||.||        |||.....|.|
  Fly   484 PPNHPLFQRTYPTPPLSPLS----AARYHPYGKPSMLPPSLAPPGMPGLPPHP------------ 532

  Fly   513 AAAAALGPYYSPYAMYGQRMGAAH 536
                ||..|::||::||.|||::|
  Fly   533 ----ALAQYFAPYSLYGPRMGSSH 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
noc	NP_001285932.1	zf-C2H2	402..430	CDD:278523	21/28 (75%)
noc	NP_001285932.1	C2H2 Zn finger	404..430	CDD:275368	19/26 (73%)
elB	NP_523566.4	PRK13914	<111..>188	CDD:237555	24/87 (28%)
elB	NP_523566.4	C2H2 Zn finger	439..466	CDD:275368	19/26 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467648
Domainoid	1	1.000	54	1.000	Domainoid score	I7518
eggNOG	1	0.900	-	-		E1_2C18X
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4423
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1163882at2759
OrthoFinder	1	1.000	-	-		FOG0003524
OrthoInspector	1	1.000	-	-		mtm6362
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12522
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2403
	10	9.900