DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment noc and Zfp503

DIOPT Version :9

Sequence 1:	NP_001285932.1	Gene:	noc / 34847	FlyBaseID:	FBgn0005771	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001100720.1	Gene:	Zfp503 / 305687	RGDID:	1312018	Length:	645	Species:	Rattus norvegicus

Alignment Length:	647	Identity:	188/647 - (29%)
Similarity:	235/647 - (36%)	Gaps:	205/647 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VVTIGNNQYLQPDYLAPLPTT------MDAKKSPLALLAQTCSQIGADSSAVKPLLAMDKNKTKP 68
            ::|......|.|:||.|||:|      :||||||||||||||||||                 ||
  Rat    77 MLTARTGHILHPEYLQPLPSTPVSPIELDAKKSPLALLAQTCSQIG-----------------KP 124

  Fly    69 GACSSSSNSSSSSGSAEISAAKSPSGQAKSPKSSTPISSTATSASLSNTSTGEIKLAFKPYET-- 131
            ....||..||.:|.......|.|.:|..|..||. |:       .||:... |.|.:||||..
  Rat   125 DPSPSSKLSSVASNGGGAGGAGSGAGGDKDAKSG-PL-------KLSDIGV-EDKSSFKPYSKPG 180

  Fly   132 --------------------NVLSHQNQNSFKSSSSLDAEPTRPSSKNSSSA------------- 163
                                .|.:.::.....|::.....|...|..:|:||
  Rat   181 SDKKEPGGGGGGGGGGGGGGGVAAEKSGFRVPSATCQPFTPRTGSPSSSASACSPGGMLPSAGGG 245

  Fly   164 -----QERVP------SRSKSNATPTDGGKA---------------EISAH-DSSSSRKTVSP-- 199
                 .::.|      |...|...|.||..|               :::.| :.....|.:|.
  Rat   246 PEGKDDKKDPEAGGGGSSKGSGGAPADGVPAGLAHGRISCGSGINVDVNQHSEGGPGGKALSSDC 310

  Fly   200 --SGSSQRGASPIVRSGMEVLNNANGTAQHPKEMSSMAAAAAAAAAAY--KAAGPYGLNPLSALC 260
              |.||..|:.|...:...||.:.......|.:..........|...|  ..||.|...|...|
  Rat   311 GGSSSSSSGSGPSAPTSSSVLGSGLVAPVSPYKPGQTVFPLPPAGMTYPGSLAGAYAGYPPQFL- 374

  Fly   261 CPPGMEQHANPAFRPPFAGGFSHHHAAMLAVAANGGYPGGAPGGGP--AGQPNPYISYQRIKTPA 323
             |.|:      |..|...|...   .|.||.||.|......|.|..  ||...|.:
  Rat   375 -PHGV------ALDPTKPGSLV---GAQLAAAAAGSLGCSKPAGSSPLAGASPPSV--------- 420

  Fly   324 GGEAIVPVCKDPYCQGCPYSAHTQQMLMGAPCPAGCTQCEHQKYGLAMASAAGLP---PAHP--- 382
               ....:|:||||    .|.|....|.||  .|....|.|.....|.|..:|.|   |.||
  Rat   421 ---MTASLCRDPYC----LSYHCASHLAGA--AAASASCAHDPAAAAAALKSGYPLVYPTHPLHG 476

  Fly   383 -YSQAAAAAAANAAAARSA----------------PYVCSWVVGDAYCGKRFQTSDELFSHLRTH 430
             :|...|||||.|.....|                |::|:||..:..|.|||.||:||.||||||
  Rat   477 VHSSLTAAAAAGATPPSLAGHPLYPYGFMLPNDPLPHICNWVSANGPCDKRFATSEELLSHLRTH 541

  Fly   431 T---------------GNLSDPAAAAAA----LAQSQAQSLLGTLFPPSALRAGYPTPPLSPMSA 476
            |               .:|:..||||.|    :..|.|....|||    |||        ||..|
  Rat   542 TAFPGTDKLLSGYPSSSSLASAAAAAMACHMHIPTSGAPGSPGTL----ALR--------SPHHA 594

  Fly   477 AAAAARYHPYAK---PPPGALAGGPSPFGAAGAFNPAAAAAAAALGPYYSPYAMYGQRMGAA 535
            ...::|||||:|   |.|||    |.|             ..||.||||||||:||||:..|
  Rat   595 LGLSSRYHPYSKSPLPTPGA----PVP-------------VPAATGPYYSPYALYGQRLTTA 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
noc	NP_001285932.1	zf-C2H2	402..430	CDD:278523	15/27 (56%)
noc	NP_001285932.1	C2H2 Zn finger	404..430	CDD:275368	15/25 (60%)
Zfp503	NP_001100720.1	nlz1	354..414	CDD:289188	20/70 (29%)
Zfp503	NP_001100720.1	C2H2 Zn finger	515..541	CDD:275368	15/25 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C18X
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4245
OMA	1	1.010	-	-		QHG49654
OrthoDB	1	1.010	-	-		D1163882at2759
OrthoFinder	1	1.000	-	-		FOG0003524
OrthoInspector	1	1.000	-	-		otm45249
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12522
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2403
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.870