Protein Alignment noc and znf703

DIOPT Version :9

• Sequence 1: NP_001285932.1
• Gene: noc / 34847
• FlyBaseID: FBgn0005771
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_571897.1
• Gene: znf703 / 114429
• ZFINID: ZDB-GENE-010717-1
• Length: 589
• Species: Danio rerio
• Alignment Length: 609
• Identity: 177/609 - (29%)
• Similarity: 242/609 - (39%)
• Gaps: 188/609 - (30%)

  Fly    17 QYLQPDYLAPLPTTMDAKKSPLALLAQTCSQIGADSSAVKPLLAMDKNKTKPGACSSSSNSSSSS 81
            :||||...||:...:||||||||||||||||||      ||   .....:|.|:.||||:....|
Zfish    73 EYLQPLSSAPVSIELDAKKSPLALLAQTCSQIG------KP---DPPPSSKLGSLSSSSHGDKDS 128

  Fly    82 GSAEISAAKSPSGQAKSPKSSTPISSTATSASLSNTSTGEIKLAFKPYE----------TNVLSH 136
            .|:. |:.||...|....|||                       ||||.          ..:.|.
Zfish   129 RSSS-SSLKSGEHQNLDDKSS-----------------------FKPYSKTGSECRKEGAGINSS 169

  Fly   137 QNQNSFK----SSSSL-------DAEPTRPSSKNSSSAQERVPSRSK----------------SN 174
            .::..|:    ||||:       .|...|.||...:|.|.....:|:                |.
Zfish   170 ADKAGFRVPNGSSSSVTCTSLPPHAPSPRASSPQQTSGQSHTHRQSQSPLSQKTAHLQTTHMDSK 234

  Fly   175 ATPTDGGKAEISAHDSSSSRKTVSPSGSSQRGA--SPIVRSGMEVLNNANGTAQHPKEMSSMAAA 237
            |..:|.|      :||||       |||.:.|.  |...:|.::|:..||         ||.|.|
Zfish   235 AAGSDPG------NDSSS-------SGSDRNGKKDSDHNKSSLDVVQIAN---------SSHARA 277

  Fly   238 AAAAAAAYKAAGPYGLNPLSALCCPPGMEQ----HANPA--FRP-----PFAGGFSHHHAAMLAV 291
            :..:::|..::.|   .|.|.....|....    |..|.  |:|     |.......:|.::  |
Zfish   278 SVNSSSASSSSSP---QPDSKTDSQPPQPSLGTGHIAPVSPFKPGHSVFPLPSSTMGYHGSI--V 337

  Fly   292 AANGGYPGG-APGGGPA------GQPNPYISYQRIKTPAGGEAIVPVCKDPYCQGCPYSAHTQQM 349
            .|..|||.. .||..||      |.|..:.|...:...:....:..:|:||||...|.:.|
Zfish   338 GAYTGYPSQFVPGLDPAKSSLGMGVPGKHPSSSPLTGASPPSFMQGLCRDPYCLTYPNAPH---- 398

  Fly   350 LMGAPCPAGCTQCEHQKYGLAMASAAGLPPAHP----YSQAAAAAAANAAAARS----------- 399
             :|.   :.|:.|.|..   :.|..:|.|..:|    :|...::.:::|.::.|
Zfish   399 -LGG---SNCSSCVHDP---SSALKSGFPLMYPTHHLHSLHPSSLSSSATSSLSHPLYTYGFMLP 456

  Fly   400 ---APYVCSWVVGDAYCGKRFQTSDELFSHLRTHTGNLSDPAAAAAALAQSQAQSLLGTLFPPSA 461
               .|:.|:||.....|.|||.||:||.:||||||           ||.....:.|.|  :|.|.
Zfish   457 NETLPHACNWVSVGGPCDKRFATSEELLAHLRTHT-----------ALPGVDGKLLSG--YPSSV 508

  Fly   462 LRAG----YPTPPLSP----------MSAAAAAARYHPYAKPPPGALAGGPS-PFGAAGAFNPAA 511
            ..|.    :..||.||          .|.....||||||.|   ..|.|.|| |..:.    ||.
Zfish   509 SSAASCHLHLPPPSSPGALPSSLSLRGSPGLGLARYHPYGK---AHLPGAPSLPMHSL----PAT 566

  Fly   512 AAAAAALGPYYSPYAMYGQRMGAA 535
            |       |||||||:|.||:|:|
Zfish   567 A-------PYYSPYALYSQRLGSA 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
noc	NP_001285932.1	zf-C2H2	402..430	CDD:278523	14/27 (52%)
		C2H2 Zn finger	404..430	CDD:275368	14/25 (56%)
znf703	NP_571897.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..315		66/270 (24%)
		nlz1	328..374	CDD:289188	13/47 (28%)
		Required for interaction with Groucho and hdac2 plays an important role in repression of transcription	408..460		8/54 (15%)
		C2H2 Zn finger	464..490	CDD:275368	14/25 (56%)
		Required for self-association and nuclear localization	498..589		37/102 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593935
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C18X
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4423
OMA	1	1.010	-	-		QHG49654
OrthoDB	1	1.010	-	-		D1163882at2759
OrthoFinder	1	1.000	-	-		FOG0003524
OrthoInspector	1	1.000	-	-		mtm6362
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12522
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4691
SonicParanoid	1	1.000	-	-		X2403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.900