DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elB and ZNF503

DIOPT Version :9

Sequence 1:	NP_523566.4	Gene:	elB / 34844	FlyBaseID:	FBgn0004858	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_116161.2	Gene:	ZNF503 / 84858	HGNCID:	23589	Length:	646	Species:	Homo sapiens

Alignment Length:	652	Identity:	168/652 - (25%)
Similarity:	234/652 - (35%)	Gaps:	197/652 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLQSSNHHYLRPDYM----TAAAAPTAQLDNKSSPLALLAQTCSAIGADTTNPKLLAANIEKSTK 61
            ||.:...|.|.|:|:    :...:| .:||.|.|||||||||||.||....:|....:::..
Human    79 MLTARTGHILHPEYLQPLPSTPVSP-IELDAKKSPLALLAQTCSQIGKPDPSPSSKLSSVAS--- 139

  Fly    62 QLQHHPKGSSGSGG---------SGSFGLSQQASMDGSA--------RDKSSP------------ 97
                :..|:.|:||         ||...||.....|.|:        .||..|
Human   140 ----NGGGAGGAGGGAAGDKDTKSGPLKLSDIGVEDKSSFKPYSKPGSDKKEPGGGGGGGGGGGG 200

  Fly    98 ----VSSHSSSVSTGSVEQQQLPPAHGSSSSSKPTPTTFKPYEPNNNISNITTAADCGATNLSSN 158
                |||..|.....|...|...|..||.|||                     |:.|....:.|:
Human   201 GGGGVSSEKSGFRVPSATCQPFTPRTGSPSSS---------------------ASACSPGGMLSS 244

  Fly   159 NTSAQQRVKTPKSMTNGGGQRCDSNQSASSQHRESPTAAGSLRRTPTSGLAGGVMQH-NGSPGLP 222
            ...|.:.....|....|||.:.....||..    .||.....|.:...|:...|.|| :|.||..
Human   245 AGGAPEGKDDKKDTDVGGGGKGTGGASAEG----GPTGLAHGRISCGGGINVDVNQHPDGGPGGK 305

  Fly   223 PTASTTPGRSNSKESAAMHSPSAAAAAAAAAAQIASSNRLQEAALAAAKEANYVKALHAASQQGS 287
            ...|...|.|.|...:...:|::::...:...          |.::..|....|..|..|.....
Human   306 ALGSDCGGSSGSSSGSGPSAPTSSSVLGSGLV----------APVSPYKPGQTVFPLPPAGMTYP 360

  Fly   288 ASAAAAAASYYPPGYGSPYSMDLMTASSLMSPHHAMFKASAM--NPYLNYARMKGLTEQSMMAAT 350
            .|.|.|.|.|.|.......::|.....||:....|...|.::  :.....:.:.|.:..|:|  |
Human   361 GSLAGAYAGYPPQFLPHGVALDPTKPGSLVGAQLAAAAAGSLGCSKPAGSSPLAGASPPSVM--T 423

  Fly   351 PNVCRDPYCTGCPASPHYINKAAGQPCPAGCPQCEGGGGGGGGSSKSSGSQGGSGGSSSAAAAAA 415
            .::||||||.....:.|.                             :|:...|...:...||||
Human   424 ASLCRDPYCLSYHCASHL-----------------------------AGAAAASASCAHDPAAAA 459

  Fly   416 AAAASSY------------HAQLAALAAA---------------------SQMPYVCSWIGSDAA 447
            ||..|.|            |:.|.|.|||                     ..:|::|:|:.::..
Human   460 AALKSGYPLVYPTHPLHGVHSSLTAAAAAGATPPSLAGHPLYPYGFMLPNDPLPHICNWVSANGP 524

  Fly   448 YCGKRFGTSDDLFQHLRTHTA---------SVP--DAVLSAAAA----------GGIP------- 484
             |.|||.||::|..|||||||         ..|  .::.|||||          .|.|
Human   525 -CDKRFATSEELLSHLRTHTAFPGTDKLLSGYPSSSSLASAAAAAMACHMHIPTSGAPGSPGTLA 588

  Fly   485 ---PNHPLFQRTYPTPPLSPLSAARYHPYGKPSMLPPSLAPPGMPGLPPHPALAQYFAPYSLYGP 546
               |:|.|           .|| :|||||.| |.||    .||.| :|...|...|::||:|||.
Human   589 LRSPHHAL-----------GLS-SRYHPYSK-SPLP----TPGAP-VPVPAATGPYYSPYALYGQ 635

  Fly   547 RM 548
            |:
Human   636 RL 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elB	NP_523566.4	PRK13914	<111..>188	CDD:237555	17/76 (22%)
elB	NP_523566.4	C2H2 Zn finger	439..466	CDD:275368	12/26 (46%)
ZNF503	NP_116161.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..332		54/242 (22%)
		nlz1	355..415	CDD:289188	12/59 (20%)
		C2H2 Zn finger	516..542	CDD:275368	12/26 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158068
Domainoid	1	1.000	57	1.000	Domainoid score	I10878
eggNOG	1	0.900	-	-		E1_2C18X
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4332
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49654
OrthoDB	1	1.010	-	-		D1163882at2759
OrthoFinder	1	1.000	-	-		FOG0003524
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12522
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.960