Protein Alignment ppk and ASIC3

DIOPT Version :9

• Sequence 1: NP_477232.1
• Gene: ppk / 34843
• FlyBaseID: FBgn0020258
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_064717.1
• Gene: ASIC3 / 9311
• HGNCID: 101
• Length: 549
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 116/593 - (19%)
• Similarity: 198/593 - (33%)
• Gaps: 182/593 - (30%)

  Fly    69 YAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCISVYFAVSLIWDTYLKWQESPVILGFDETLVPVH 133
            :|.:.::||:.::|........:..|.....:||...:..:.:....::|.......||.  ..|
Human    20 FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDER--ESH 82

  Fly   134 KIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQNGNISDLDDEDLARMAVAMHICDSEVVQRF 198
            ::.||.:|:|       |:    |..|:           |.|...||.....|:...|......|
Human    83 RLIFPAVTLC-------NI----NPLRR-----------SRLTPNDLHWAGSALLGLDPAEHAAF 125

  Fly   199 TPLLSQ-------LNPPNVDVTQTLIDLSISKNETGPFCKWNGRFYFC-DKIFDFVATDEGICYQ 255
            ...|.:       :..|..|:.|.......|.::....|::.|:  .| .:.|..:.|..|.||.
Human   126 LRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQ--PCGPENFTTIFTRMGKCYT 188

  Fly   256 F------------------NGLRPKDIYRDEKFISYVDPDVVDFNKYFDVDLPPWNNITGNWSLD 302
            |                  |||   ||..|.:...|               ||.|.
Human   189 FNSGADGAELLTTTRGGMGNGL---DIMLDVQQEEY---------------LPVWR--------- 226

  Fly   303 TGFVDQGQNAYPQRTVFSSVKNGFFAFLQGLQHNFDYDCRSFKQGYKVFLNSPESVPL------- 360
                                               |.:...|:.|.:|.::|.|..|:
Human   227 -----------------------------------DNEETPFEVGIRVQIHSQEEPPIIDQLGLG 256

  Fly   361 -TTG------------NYILVPHGDEVLVSVLPAYVVS-TDNLHEITPEKRQCLFDDERSLRFFR 411
             :.|            :::..|.||....|:.|.|... :|.|...:|....
Human   257 VSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSP------------- 308

  Fly   412 SYSQSNCQTECLANYTVSKCGCAKFWMPKPLGTPVCGLKDI-NCYTSAQDELYTLMQNQTMAKSI 475
            .|:...|:..|...|...||||...:||..:  |||..:.. ||...|.|.:        :.|.
Human   309 PYTLMGCRLACETRYVARKCGCRMVYMPGDV--PVCSPQQYKNCAHPAIDAM--------LRKD- 362

  Fly   476 DESVDITCNCMPACTSLEYNFEISRAKYDVAKTIRAFREEYEHTDAIGSR----LSVYFKEHQFT 536
                  :|.|...|.|..|..|:|..:.......|....:...::|..:.    |.::|:...:.
Human   363 ------SCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYE 421

  Fly   537 AIKRTILFGVSTLISNCGGICGLFMGISCLSFLELIYFFCMRICGSCRDR-------RKHKIQQQ 594
            .:::...:.:|.|:.:.||..|||:|.|.|:.||::.:    :|...||:       |:|. |:.
Human   422 TVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDY----LCEVFRDKVLGYFWNRQHS-QRH 481

  Fly   595 NSVDLPEE 602
            :|.:|.:|
Human   482 SSTNLLQE 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:279230	107/556 (19%)
ASIC3	NP_064717.1	ASC	20..534	CDD:295594	116/593 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..307		6/21 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7068
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4987
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.970