DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk and Asic4

DIOPT Version :9

Sequence 1:	NP_477232.1	Gene:	ppk / 34843	FlyBaseID:	FBgn0020258	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_071570.2	Gene:	Asic4 / 63882	RGDID:	621068	Length:	539	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	115/541 - (21%)
Similarity:	180/541 - (33%)	Gaps:	131/541 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SPLSACKGL-----LLEYAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCIS----VYFAVSLIWDT 112
            |.|.|.:|.     |..:|.::|:||:............:..|:.....|    :|.|.||. ..
  Rat    28 SLLGAAQGPAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWVLALLTSLAAFLYQAASLA-RG 91

  Fly   113 YLKWQESPVILGFDETLVPVHKIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQNGNISDLDD 177
            ||   ..|.::..|.. .|.....||.:|:|             |::|     ::.    |.|.|
  Rat    92 YL---TRPHLVAMDPA-APAPVAGFPAVTLC-------------NINR-----FRH----SALSD 130

  Fly   178 EDLARMAVAMHICDSEVVQRFTPLLSQLNPPNVDVT----QTLIDLSISKNETGPFCKWNGRFYF 238
            .|:..:|....:...:........|....|..||:.    ..|.|:..|.|.:|..|..:.
  Rat   131 ADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQLADMLKSCNFSGHHCSASN---- 191

  Fly   239 CDKIFDFVATDEGICYQFNGLRPKDIYRDEKFISYVDPDVVDFNKYFDVDLPPWNNITGNWSLDT 303
                |..|.|..|.||.||                .||
  Rat   192 ----FSVVYTRYGKCYTFN----------------ADP--------------------------- 209

  Fly   304 GFVDQGQNAYPQRTVFSSVKNGFFAFLQGLQHNF-----DYDCRSFKQGYKVFLNSPESVPLTTG 363
                  |::.|.|.  ..:.:|....|...|..:     :.:..||:.|.:|.::|.|..|....
  Rat   210 ------QSSLPSRA--GGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQ 266

  Fly   364 NYILVPHGDEVLVSVLPAYVVSTDNLHEITPEKRQCLFDD---ERSLRFFRSYSQSNCQTECLAN 425
            ....|..|.:..||      .....|..:......|..:.   |..|:.:.:||.|.|:..|...
  Rat   267 LGFGVSPGFQTFVS------CQEQRLTYLPQPWGNCRAESKLREPELQGYSAYSVSACRLRCEKE 325

  Fly   426 YTVSKCGCAKFWMPKPLGTPVCGLKDINCYTSAQDELYTLMQNQTMAKSIDESVDITCNCMPACT 490
            ..:.:|.|....||.  ...:|   ..|.|....|  :||       .|:....:..|.|...|.
  Rat   326 AVLQRCHCRMVHMPG--NETIC---PPNIYIECAD--HTL-------DSLGGGSEGPCFCPTPCN 376

  Fly   491 SLEYNFEISRAKYDVAKTIRAFREEYEHTDAIGSR----LSVYFKEHQFTAIKRTILFGVSTLIS 551
            ...|..|||..|.....:.|....:|...:.....    |.|:|:.....|:::...:|:|.|:.
  Rat   377 LTRYGKEISMVKIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLG 441

  Fly   552 NCGGICGLFMGISCLSFLELI 572
            :.||..|||:|.|.|:.||::
  Rat   442 DLGGQMGLFIGASILTLLEIL 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:279230	110/524 (21%)
Asic4	NP_071570.2	ASC	40..488	CDD:295594	111/529 (21%)
Asic4	NP_071570.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920