DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk and Asic4

DIOPT Version :10

Sequence 1:NP_477232.1 Gene:ppk / 34843 FlyBaseID:FBgn0020258 Length:606 Species:Drosophila melanogaster
Sequence 2:NP_071570.2 Gene:Asic4 / 63882 RGDID:621068 Length:539 Species:Rattus norvegicus


Alignment Length:541 Identity:115/541 - (21%)
Similarity:180/541 - (33%) Gaps:131/541 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 SPLSACKGL-----LLEYAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCIS----VYFAVSLIWDT 112
            |.|.|.:|.     |..:|.::|:||:............:..|:.....|    :|.|.||. ..
  Rat    28 SLLGAAQGPAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWVLALLTSLAAFLYQAASLA-RG 91

  Fly   113 YLKWQESPVILGFDETLVPVHKIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQNGNISDLDD 177
            ||   ..|.::..|.. .|.....||.:|:|             |::|     ::.    |.|.|
  Rat    92 YL---TRPHLVAMDPA-APAPVAGFPAVTLC-------------NINR-----FRH----SALSD 130

  Fly   178 EDLARMAVAMHICDSEVVQRFTPLLSQLNPPNVDVT----QTLIDLSISKNETGPFCKWNGRFYF 238
            .|:..:|....:...:........|....|..||:.    ..|.|:..|.|.:|..|..:.    
  Rat   131 ADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQLADMLKSCNFSGHHCSASN---- 191

  Fly   239 CDKIFDFVATDEGICYQFNGLRPKDIYRDEKFISYVDPDVVDFNKYFDVDLPPWNNITGNWSLDT 303
                |..|.|..|.||.||                .||                           
  Rat   192 ----FSVVYTRYGKCYTFN----------------ADP--------------------------- 209

  Fly   304 GFVDQGQNAYPQRTVFSSVKNGFFAFLQGLQHNF-----DYDCRSFKQGYKVFLNSPESVPLTTG 363
                  |::.|.|.  ..:.:|....|...|..:     :.:..||:.|.:|.::|.|..|....
  Rat   210 ------QSSLPSRA--GGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQ 266

  Fly   364 NYILVPHGDEVLVSVLPAYVVSTDNLHEITPEKRQCLFDD---ERSLRFFRSYSQSNCQTECLAN 425
            ....|..|.:..||      .....|..:......|..:.   |..|:.:.:||.|.|:..|...
  Rat   267 LGFGVSPGFQTFVS------CQEQRLTYLPQPWGNCRAESKLREPELQGYSAYSVSACRLRCEKE 325

  Fly   426 YTVSKCGCAKFWMPKPLGTPVCGLKDINCYTSAQDELYTLMQNQTMAKSIDESVDITCNCMPACT 490
            ..:.:|.|....||.  ...:|   ..|.|....|  :||       .|:....:..|.|...|.
  Rat   326 AVLQRCHCRMVHMPG--NETIC---PPNIYIECAD--HTL-------DSLGGGSEGPCFCPTPCN 376

  Fly   491 SLEYNFEISRAKYDVAKTIRAFREEYEHTDAIGSR----LSVYFKEHQFTAIKRTILFGVSTLIS 551
            ...|..|||..|.....:.|....:|...:.....    |.|:|:.....|:::...:|:|.|:.
  Rat   377 LTRYGKEISMVKIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLG 441

  Fly   552 NCGGICGLFMGISCLSFLELI 572
            :.||..|||:|.|.|:.||::
  Rat   442 DLGGQMGLFIGASILTLLEIL 462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppkNP_477232.1 ASC 69..574 CDD:459966 110/524 (21%)
Asic4NP_071570.2 ENaC 40..488 CDD:273304 111/529 (21%)
GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348 452..454 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..531
Blue background indicates that the domain is not in the aligned region.

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