DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk and Asic5

DIOPT Version :10

Sequence 1:NP_477232.1 Gene:ppk / 34843 FlyBaseID:FBgn0020258 Length:606 Species:Drosophila melanogaster
Sequence 2:NP_071563.1 Gene:Asic5 / 63866 RGDID:69295 Length:495 Species:Rattus norvegicus


Alignment Length:559 Identity:119/559 - (21%)
Similarity:192/559 - (34%) Gaps:181/559 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 EYAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCISVYFAVSLIWD------TYLKWQESPVILGFD 126
            ::|.||:.|||..|.:....: .|:.||.....||..   |:|.      .|..|..:..|    
  Rat    40 DFAISTSFHGIHNIAQNQNKV-RKVIWLSVVLGSVSL---LVWQIYSRLVNYFMWPTTTSI---- 96

  Fly   127 ETLVPVHKIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQNGNISDLDDEDLARMAVAMHICD 191
             .:..|.||.||.:|.|                           |::....|.::|..:...:.|
  Rat    97 -EVQYVEKIEFPAVTFC---------------------------NLNRFQTEAVSRFGIIFFLWD 133

  Fly   192 --SEVVQRFTPLLSQLNPPNVDVTQTLIDLSISKN-ETGPFCKWNGRFYF--------------C 239
              |:|::     |.:::..|....:.|..::..:| ....|.|.|| ||.              |
  Rat   134 IVSKVLR-----LQEISGNNTGSPEALDFVASHRNFSITEFVKNNG-FYLNHDTLVHCEFFGKTC 192

  Fly   240 D-KIFDFVATDEGICYQFN----------------GLR-PKDIYRDEKFISYVDPDVVDFNKYFD 286
            | |.|..|.|:.|.|:.||                ||: ..|::::|               :.|
  Rat   193 DPKDFKHVFTEYGNCFTFNYGENVQSKNKVSVSGRGLKLLLDVHQEE---------------FTD 242

  Fly   287 VDLPPWNNITGNWSLDTGFVDQGQNAYPQRTVFSSVKNGFFAFLQGLQHNFDYDCRSFKQGYKVF 351
            ..:|             ||.|.|       .:|                               .
  Rat   243 NPVP-------------GFADAG-------VIF-------------------------------V 256

  Fly   352 LNSPESVPLTTGNYILVPHGDEVLVSVLPAYVVSTDNLHEITPEKRQCLFDDERSLRFFRSYSQS 416
            ::||:..|...|..:..|.|....|::.     ....:|:..| ..:|  :.:..||.|.:||..
  Rat   257 IHSPKKEPQFDGLGLSSPVGMHARVTIR-----QLKTIHQEYP-WGEC--NPDIKLRNFTTYSTY 313

  Fly   417 NCQTECLANYTVSKCGCAKFWMPKPLGTPV-CG-LKDINCYTSAQDELYTLMQNQTMAKSIDESV 479
            .|..||.|.:....|||..|.:|   |..| |. ||..||.:...|.:        ..|.:....
  Rat   314 GCLKECKAKHIQRLCGCLPFLLP---GNGVECDLLKYYNCVSPILDHI--------ERKGLCTMG 367

  Fly   480 DITCNCMPACTSLEY-------NFEISRAKYDVAKTIRAFREEYEHTDAIGSRLSVYFKEHQFTA 537
            ....:|...|...||       .|...||...:||.:.. .:||...:.:...::.....::.|.
  Rat   368 THNSSCPVPCEETEYPATIAYSTFPSQRATKFLAKKLNQ-SQEYIRENLVNIEINYSDLNYKITQ 431

  Fly   538 IKRTILFGVSTLISNCGGICGLFMGISCLSFLELI-YFF 575
            .::.:  .|..|:::.||..|||.|.|.::.:|:| |.|
  Rat   432 QQKAV--SVPELLADVGGQLGLFCGASLITIIEIIEYLF 468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppkNP_477232.1 ASC 69..574 CDD:459966 117/555 (21%)
Asic5NP_071563.1 Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000269|PubMed:27679529 1..30
ASC 41..466 CDD:459966 117/554 (21%)
GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348 454..456 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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