DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk and SCNN1G

DIOPT Version :10

Sequence 1:NP_477232.1 Gene:ppk / 34843 FlyBaseID:FBgn0020258 Length:606 Species:Drosophila melanogaster
Sequence 2:NP_001030.2 Gene:SCNN1G / 6340 HGNCID:10602 Length:649 Species:Homo sapiens


Alignment Length:662 Identity:131/662 - (19%)
Similarity:214/662 - (32%) Gaps:250/662 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 IKSRIRYGSPLS-----ACKGLLLEYAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCISVYFAVSL 108
            ||::|:...|::     ..|.|:..|..:|..||.|.|. |.|....:|.|:.||..    ||:|
Human     7 IKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIV-VSRGRLRRLLWIGFTLT----AVAL 66

  Fly   109 IWDTYLKWQESPVILGFDETLVPV----HKIPFPTITIC-------------------------- 143
            |     .||.:.::..|....|.:    .|:.||.:|||                          
Human    67 I-----LWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALK 126

  Fly   144 -----PEIKMERNVFDYTNVSRQLWEEYKQNG-------NISDLDDEDLAR-------------- 182
                 ||.:..|....:.:||     |.||..       .|.|.|::..||              
Human   127 SLYGFPESRKRREAESWNSVS-----EGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSI 186

  Fly   183 -------------MAVAMHICDSEVVQRFTPLLS----------QLNPPNVDVTQTL---IDLSI 221
                         ..|...:|.::.....|...|          :|:..|:.....|   |::|.
Human   187 IHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSY 251

  Fly   222 SKNETGPFCKWNGRFYFCDKIFDFVATD-----------EGICYQFNGLRPKDIYRDEKFISYVD 275
            |..|....|           .||.|:.|           .|.||.||.       |:.:.|    
Human   252 SAEELLVTC-----------FFDGVSCDARNFTLFHHPMHGNCYTFNN-------RENETI---- 294

  Fly   276 PDVVDFNKYFDVDLPPWNNITGNWSLDTGFVDQGQNAYPQRTVFSSVKNGFFAFLQGLQHNFDYD 340
                                     |.|   ..|.:.|                  |||      
Human   295 -------------------------LST---SMGGSEY------------------GLQ------ 307

  Fly   341 CRSFKQGYKVFLNSPESVPL---TTGNYILVPHGDEV-----LVSVLPAYVVSTDNLH-----EI 392
                   ..:::|..|..|.   :||..:::...||.     :.:.:...:|::..:|     ::
Human   308 -------VILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKL 365

  Fly   393 TPEKRQCLFDDE----RSLRFFRSYSQSNCQTECLANYTVSKCGCAKFWMPKPLGTPVCGLKD-- 451
            :....||..|..    |:: :..:||...|...|.....|.|||||::..|.|.....|..:.  
Human   366 SEPYSQCTEDGSDVPIRNI-YNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHP 429

  Fly   452 --INCYTSAQDELYTL----MQNQTMAKSIDESVDITCNCMPACTSLEYNFEISRAKYDVAKTI- 509
              :.||       |.|    :|.:...:|:         |..||:..|:....|.|::....:. 
Human   430 NWMYCY-------YQLHRAFVQEELGCQSV---------CKEACSFKEWTLTTSLAQWPSVVSEK 478

  Fly   510 -----------RAFREEYEHTDAIGSRLSVYFKEHQFTAIKRTILFGVSTLISNCGGICGLFMGI 563
                       |...::...||.  ::|.:::|:....:|..:....:..|:||.||..||:|..
Human   479 WLLPVLTWDQGRQVNKKLNKTDL--AKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSC 541

  Fly   564 SCLSFLELIYFF 575
            |.:..:|:|..|
Human   542 SVVCVIEIIEVF 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppkNP_477232.1 ASC 69..574 CDD:459966 124/634 (20%)
SCNN1GNP_001030.2 ENaC 24..630 CDD:273304 127/645 (20%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000269|PubMed:30251954, ECO:0000269|PubMed:32729833 135..221 14/90 (16%)
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:17502380 623..627
Blue background indicates that the domain is not in the aligned region.

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