Protein Alignment ppk and SCNN1B

DIOPT Version :10

• Sequence 1: NP_477232.1
• Gene: ppk / 34843
• FlyBaseID: FBgn0020258
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 626
• Identity: 135/626 - (21%)
• Similarity: 225/626 - (35%)
• Gaps: 162/626 - (25%)

  Fly    52 RIRYGSPLSACKGLLLEYAKSTTIHG-IRYIFEVHRPIYEKLYWLFFTCISVYFAVSLIWD---- 111
            |::.| |....|.||:.|..:|..|| .|.|.|..:   :|..|...|.:   ||..:.|.
Human    32 RLQKG-PGYTYKELLVWYCDNTNTHGPKRIICEGPK---KKAMWFLLTLL---FAALVCWQWGIF 89

  Fly   112 --TYLKWQES-PVILGFDETLVPVHKIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQNGNIS 173
              |||.|:.| .:.:||       ..:.||.:|||     ..:.|.|:.:...|          .
Human    90 IRTYLSWEVSVSLSVGF-------KTMDFPAVTIC-----NASPFKYSKIKHLL----------K 132

  Fly   174 DLDD--EDLARMAVAMHICDSEVVQRF-------TP--LLSQLNP--PNV-----DVTQTLIDLS 220
            |||:  |.:....:|..:..:...:..       ||  |:.:.||  |.|     |....|...|
Human   133 DLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSS 197

  Fly   221 ISK---NETGPFCKWNGRFYFCDK----IFDFVATDEGICYQFNGLRPKDIY-----RDEKFISY 273
            .|:   |..|  ||...|....::    ..:|.:..:.:. ::..|:..:|:     ::...:||
Human   198 ASEKICNAHG--CKMAMRLCSLNRTQCTFRNFTSATQALT-EWYILQATNIFAQVPQQELVEMSY 259

  Fly   274 VDPDVV----------DFNKYFDVDLPPWNN-ITGNWSLDTGFVDQGQNAYPQ---------RTV 318
            ....::          ::..:..:..|.:.| ...||.:.       :.|.|.         :.:
Human   260 PGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT-------EKALPSANPGTEFGLKLI 317

  Fly   319 FSSVKNGFFAFLQGLQHNFDYDCRSFKQGYKVFLNSPESVPLTTGNYILVPHGDEVLVSVLPAYV 383
            ....:..:..||            :...|.::.|:...|.|......|....|.|..:.||
Human   318 LDIGQEDYVPFL------------ASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVL---- 366

  Fly   384 VSTDNLHEITPEKRQCLFD-DERSLRFFRS-----YSQSNCQTECLANYTVSKCGCAKFWMPKPL 442
              .|.|..:......|..: .|..::.|.|     ||...|...|..::.:..|.|..:..|.|.
Human   367 --VDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPR 429

  Fly   443 GTPVCGLKDI----NCYTSAQDELYTLMQNQTMAKSIDESVDITC--NCMPACTSLEYNFEISRA 501
            |...|..:|.    :||:..|   .::.|.:            ||  .|..:|...:|...||.|
Human   430 GEKYCNNRDFPDWAHCYSDLQ---MSVAQRE------------TCIGMCKESCNDTQYKMTISMA 479

  Fly   502 KY-DVAKTIRAF----REEYEHTDAIGSR-----LSVYFKEHQFTAIKRTILFGVSTLISNCGGI 556
            .: ..|.....|    :|..:.|:...||     |::||:|..:..|:.:....:..|:||.||.
Human   480 DWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQ 544

  Fly   557 CGLFMG--ISCL-SFLELIYFF-------CMRICGSCRDRR 587
            .|.:||  :.|| .|.|:|..|       .:.:..|.|.||
Human   545 FGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRR 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:459966	124/587 (21%)
SCNN1B	XP_016879014.1	ENaC	40..642	CDD:273304	132/617 (21%)