Protein Alignment ppk and SCNN1A

DIOPT Version :9

• Sequence 1: NP_477232.1
• Gene: ppk / 34843
• FlyBaseID: FBgn0020258
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 125/625 - (20%)
• Similarity: 205/625 - (32%)
• Gaps: 219/625 - (35%)

  Fly    69 YAKSTTIHG-IRYIFEVHRPIYEKLYWLFFTCI--SVYFAVSLIWDTYLKWQESPVILGFDETLV 130
            :..:||||| ||.:...|..:....:.:.:.|.  .:|:...|::..|..:   ||.|..:   :
Human   121 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSY---PVSLNIN---L 179

  Fly   131 PVHKIPFPTITIC-------PEIKMERNVFDYTNVSRQ-LWEEYKQN-------GNISDLD---- 176
            ...|:.||.:|||       ||||.|....|  .::.| |::.||.:       |:.|..|
Human   180 NSDKLVFPAVTICTLNPYRYPEIKEELEELD--RITEQTLFDLYKYSSFTTLVAGSRSRRDLRGT 242

  Fly   177 -DEDLARMAVAMHICDSEVVQRFTPLLSQL--NPPNVDVTQTLIDLSI-SKNETGPFC------- 230
             ...|.|:.|..   .....:|...:.|.|  |.|.||.....|...: ::|::..|.
Human   243 LPHPLQRLRVPP---PPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGV 304

  Fly   231 ----KWN-----------------------GRFYFCDKIFDFVATDE-----------GICYQFN 257
                :|.                       |.|.|..: |:.|:.::           |.||.||
Human   305 DAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACR-FNQVSCNQANYSHFHHPMYGNCYTFN 368

  Fly   258 GLRPKDIYRDEKFISYVDPDVVDFNKYFDVDLPPWNNITGNWSLDTGFVDQGQNAYPQRTVFSSV 322
            .                                  .|.:..|          .::.|      .:
Human   369 D----------------------------------KNNSNLW----------MSSMP------GI 383

  Fly   323 KNGFFAFLQGLQHNFDYDCRSFKQGYKVFLN-SPESVPLTTGNYILVPHGDEVLVSVLPAYV--- 383
            .||....|:..|::| ....|...|.:|.:: ..|...:..|.:.|.| |.|..:|:....:
Human   384 NNGLSLMLRAEQNDF-IPLLSTVTGARVMVHGQDEPAFMDDGGFNLRP-GVETSISMRKETLDRL 446

  Fly   384 -------------VSTDNLHEITPEKRQCLFDDERSLRFFRSYSQSNCQTECLANYTVSKCGCAK 435
                         |..:||:   |.|                |:|..|...|.....:.:||||.
Human   447 GGDYGDCTKNGSDVPVENLY---PSK----------------YTQQVCIHSCFQESMIKECGCAY 492

  Fly   436 FWMPKPLGTPVCGLKDIN----CYTSAQ-----DEL--YTLMQNQTMAKSIDESVDITCNCMPAC 489
            .:.|:|.....|..:..:    ||...|     |.|  :|..:......|...|...  :..|:.
Human   493 IFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY--SRWPSV 555

  Fly   490 TSLEY---------NFEISRAKYDVAKTIRAFREEYEHTDAIGSRLSVYFKEHQFTAIKRTILFG 545
            ||.|:         |:.::..:..|||                  ::::|||..:.....:....
Human   556 TSQEWVFQMLSRQNNYTVNNKRNGVAK------------------VNIFFKELNYKTNSESPSVT 602

  Fly   546 VSTLISNCGGICGLFMGISCLSFLE--------LIYFFCM 577
            :.||:||.|....|:.|.|.||.:|        |:..|.|
Human   603 MVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLM 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:279230	123/620 (20%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	125/625 (20%)
		deg-1	121..631	CDD:273309	122/612 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820