Protein Alignment ppk and ASIC5

DIOPT Version :10

• Sequence 1: NP_477232.1
• Gene: ppk / 34843
• FlyBaseID: FBgn0020258
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 121/548 - (22%)
• Similarity: 205/548 - (37%)
• Gaps: 149/548 - (27%)

  Fly    68 EYAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCISVYFAVSLI-WDTYLK------WQESPVILGF 125
            ::|.||:.|||..|.: :|....::.||    :.|..:|||: |..|::      |..:..|
Human    40 DFAISTSFHGIHNIVQ-NRSKIRRVLWL----VVVLGSVSLVTWQIYIRLLNYFTWPTTTSI--- 96

  Fly   126 DETLVPVHKIPFPTITICPEIKMERNVFDYTNVSRQLW---------EEYKQNGNISDLDDEDLA 181
              .:..|.|:.||.:|.|...:.:.:......|...||         :|...| :....:..|.|
Human    97 --EVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITAN-STGSREATDFA 158

  Fly   182 RMAVAMHICDSEVVQRFTPLLSQLNPPNVDVTQTLIDLSISKNETGPFCKWNGRFYFCD-KIFDF 245
                |.|       |.|:.:....|........||:|           |::.|:  .|. |.|..
Human   159 ----ASH-------QNFSIVEFIRNKGFYLNNSTLLD-----------CEFFGK--PCSPKDFAH 199

  Fly   246 VATDEGICYQFNGLRPKDIYRDEKFISYVDPDVVDFNKYFDVDLPPWNNITGNWSLDTGFVDQGQ 310
            |.|:.|.|:.||  ..:.:....|    |.......:..|:|:...:   |.|.:|  ||||.|
Human   200 VFTEYGNCFTFN--HGETLQAKRK----VSVSGRGLSLLFNVNQEAF---TDNPAL--GFVDAG- 252

  Fly   311 NAYPQRTVFSSVKNGFFAFLQGLQHNFDYDCRSFKQGYKVFLNSPESVPLTTGNYILVPHGDEVL 375
                  .:|                               .::||:.||...|..:|.|.|....
Human   253 ------IIF-------------------------------VIHSPKKVPQFDGLGLLSPVGMHAR 280

  Fly   376 VSVLPAYVVSTDNLHEITPEKRQCLFDDERSLRFFRSYSQSNCQTECLANYTVSKCGCAKFWMPK 440
            |::.....|     |:..| ..:|  :....|:.|.|||.|.|..||.|.:...:|||..|.:|
Human   281 VTIRQVKTV-----HQEYP-WGEC--NPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLP- 336

  Fly   441 PLGTPV-CGL-KDINCYTSAQDELYTLMQNQTMAKSIDESVDI------TCNCMPACTSLEYNFE 497
              |..: |.| |..:|.:...|.:              |..|:      ..:|..:|..:||...
Human   337 --GYGIECDLQKYFSCVSPVLDHI--------------EFKDLCTVGTHNSSCPVSCEEIEYPAT 385

  Fly   498 ISRAKYDVAKTIRAFRE------EYEHTDAIGSRLSVYFKEHQFTAIKRTILFGVSTLISNCGGI 556
            ||.:.:...|.::...:      :|...:.:  ::.:.:.:..:...::.....||.|:::.||.
Human   386 ISYSSFPSQKALKYLSKKLNQSRKYIRENLV--KIEINYSDLNYKITQQQKAVSVSELLADLGGQ 448

  Fly   557 CGLFMGISCLSFLELI-------YFFCM 577
            .|||.|.|.::.:|:|       |:.|:
Human   449 LGLFCGASLITIIEIIEYLFTNFYWICI 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:459966	119/542 (22%)
ASIC5	NP_059115.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30
		ASC	41..466	CDD:459966	119/535 (22%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)