DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk and ppk19

DIOPT Version :9

Sequence 1:	NP_477232.1	Gene:	ppk / 34843	FlyBaseID:	FBgn0020258	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_651708.2	Gene:	ppk19 / 43489	FlyBaseID:	FBgn0039679	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	121/546 - (22%)
Similarity:	215/546 - (39%)	Gaps:	113/546 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 TTIHGIRYIF-EVHRPIYEKLYWLFFTCISVYFAVSLIWDTYLKWQESPVILGFDETLVPVHKIP 136
            :.|||::::| |.|  ::::..||.....:|....||......:..|..::...:.|.:||:.|.
  Fly    40 SNIHGMQHVFGEQH--LWQRCLWLAIVLGAVITGFSLYTVLMHRHSEQLLVSLIETTQLPVYHID 102

  Fly   137 FPTITICPEIKMERNVFDYTNV------------SRQLWEEYKQNGNISDLDDEDLARMAVAMHI 189
            ||.:.:||     .|.|::...            :.:|.|.::|              :..:|.|
  Fly   103 FPAVAVCP-----WNHFNWQRAPSAFIRFLPRHPNAELRETFRQ--------------LLASMDI 148

  Fly   190 CDSEVVQRFTPLLSQLNPPNVD----------VTQTLIDLSISKNETGPFCKWNGRFYFCDKIFD 244
            .:.....|.. :|::.|...:.          :|....:|.::.:     |.::...|.|.|:|.
  Fly   149 MNFSNFNRIR-ILTKRNLTGISYLKMTDLMNFMTYRCDELFVADS-----CVFDETPYDCCKLFV 207

  Fly   245 FVATDEGICYQFNGLRPKDIYRDEKFISYVDPDVVDFNKYFDVDLPPWNNITGNWSLDTGFVDQG 309
            ...|.:|.|..||.:..:: .|.:..|:...|.                      .|.|...|.|
  Fly   208 REQTVKGQCLVFNSMISEN-SRKKHLINQFYPH----------------------KLSTAGEDSG 249

  Fly   310 QNAYPQRTVFSSVKNGFFAFLQGLQHNFDYDCRSFKQGYKVFLNSPESVPLTTGN---YILVPHG 371
                     .....|..::|:..:.....:       |..:.:..|..    ..|   |.|.| .
  Fly   250 ---------LKFTINASYSFMNNIDALTPF-------GMNLMIKEPRQ----WSNEMMYHLYP-D 293

  Fly   372 DEVLVSVLPAYVVSTDNLHEITPEKRQCLFDDERSLRFFR---SYSQSNCQTECLANYTVSKCGC 433
            .|..|:|.|....::.|.:|::|:||:|.||||::..|..   :|::.||...||.......|.|
  Fly   294 TENFVAVHPLVTETSPNTYEMSPKKRRCYFDDEKNPTFQNTSLTYNRENCLVVCLHLVVWKTCQC 358

  Fly   434 A-KFWMPKPLGTPVCGLKDINCYTSAQDELYTLMQNQTMAKSIDES-VDITCNCMPACTSLEYNF 496
            : ..::|...|.|.||:.|..|..:..| ::|.::.....|.|::| ....|:|...|.|..|..
  Fly   359 SLPAFLPPIDGVPECGINDAQCLGNNSD-IFTYVKMGDQEKYINDSRQGHFCDCPDNCNSRLYEM 422

  Fly   497 EISRAKYDVAKTIRAFREEYEHTDAIGSRLSVYFKEHQFTAIKRTILFGVSTLISNCGGICGLFM 561
            .::..|.|..|         ..||.: .:..||:.:...|.|...:.:....|::|.|||..|::
  Fly   423 SLNVRKLDYPK---------NSTDQL-IKAQVYYGQRVMTKIITKLKYTNIDLLANFGGIISLYI 477

  Fly   562 GISCLSFLELIYFFCMRICGSCRDRR 587
            |.|.:||:||::.....:.|..||.|
  Fly   478 GASVMSFIELLFVLGKLMWGFIRDAR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:279230	117/531 (22%)
ppk19	NP_651708.2	ASC	39..489	CDD:279230	117/530 (22%)
ppk19	NP_651708.2	AceK	116..>139	CDD:295079	2/22 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920