Protein Alignment ppk and ASIC1

DIOPT Version :10

• Sequence 1: NP_477232.1
• Gene: ppk / 34843
• FlyBaseID: FBgn0020258
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 123/631 - (19%)
• Similarity: 197/631 - (31%)
• Gaps: 203/631 - (32%)

  Fly    69 YAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCISVYFAVSLIWDT-----YLKWQESPVILGFDET 128
            :|.|:|:||:.:||...|...::..|..  |.....||.|...|     |..:..   :...||
Human    21 FASSSTLHGLAHIFSYERLSLKRALWAL--CFLGSLAVLLCVCTERVQYYFHYHH---VTKLDE- 79

  Fly   129 LVPVHKIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQN------GNISDLDDEDLARMAVAM 187
             |...::.||.:|:|     ..|.|.::.||:.  :.|...      .|..::.|..:|......
Human    80 -VAASQLTFPAVTLC-----NLNEFRFSQVSKN--DLYHAGELLALLNNRYEIPDTQMADEKQLE 136

  Fly   188 HICDSEVVQRFTPLLSQLNPPNV---------DVTQTLIDLSISKNETGPFCKWNGRFYFCDKIF 243
            .:.|....:.|.|     .|.|:         |:...|:.           |.:.|.....:. |
Human   137 ILQDKANFRSFKP-----KPFNMREFYDRAGHDIRDMLLS-----------CHFRGEVCSAED-F 184

  Fly   244 DFVATDEGICYQFNGLRPKDIYRDEKFISYVDPDVVDFNKYFDVDLPPWNNITGNWSLDTGFVDQ 308
            ..|.|..|.||.||                                                  .
Human   185 KVVFTRYGKCYTFN--------------------------------------------------S 199

  Fly   309 GQNAYPQ-RTVFSSVKNGFFAFLQGLQHNF-----DYDCRSFKQGYKVFLNSPESVPLTTGNYIL 367
            |::..|: :|:.....||....|...|..:     :.|..||:.|.||.::|.:..|..
Human   200 GRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFI------ 258

  Fly   368 VPHGDEVLVSVLPAY----VVSTDNLHEITPEKRQC---LFDDERSLRFFRSYSQSNCQTECLAN 425
                |::...|.|.:    ......|..:.|....|   ..|.:  |.||.|||.:.|:.:|...
Human   259 ----DQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSD--LDFFDSYSITACRIDCETR 317

  Fly   426 YTVSKCGCAKFWMPKPLGTPVCGLKDI-NCYTSAQDELYTLMQNQTMAKSIDESVDITCNCMPAC 489
            |.|..|.|....||.  ..|.|..:.. .|...|.|.|....|..             |.|...|
Human   318 YLVENCNCRMVHMPG--DAPYCTPEQYKECADPALDFLVEKDQEY-------------CVCEMPC 367

  Fly   490 TSLEYNFEISRAKYDVAKTIRAFREEYEHTDA-IGSR---LSVYFKEHQFTAIKRTILFGVSTLI 550
            ....|..|:|..|.....:.:...:::..::. ||..   |.::|:...:..|::...:.::.|:
Human   368 NLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLL 432

  Fly   551 -----------------------SNC-----------------------GGICGLFMGISCLSFL 569
                                   :.|                       ||..|||:|.|.|:.|
Human   433 GELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGASILTVL 497

  Fly   570 ELIYF--------FCMRICGSCRDRRKHKIQQQN-SVDLPEEKSEN 606
            ||..:        .|.|  |.|:...|.....:. ::.|.:.|..|
Human   498 ELFDYAYEVIKHKLCRR--GKCQKEAKRSSADKGVALSLDDVKRHN 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:459966	115/588 (20%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	123/631 (19%)