DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk and asic1c

DIOPT Version :9

Sequence 1:	NP_477232.1	Gene:	ppk / 34843	FlyBaseID:	FBgn0020258	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	XP_021325802.1	Gene:	asic1c / 407670	ZFINID:	ZDB-GENE-040513-3	Length:	562	Species:	Danio rerio

Alignment Length:	587	Identity:	131/587 - (22%)
Similarity:	216/587 - (36%)	Gaps:	158/587 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KGLLLEYAKSTTIHGIRYIFEVHRPIYEKLYWL--FFTCISVYFAVSLIWDTYLKWQESPVILGF 125
            |.:...:...|.:||:::.|..|:...::|:||  ...|:.:.|..|  |:..|.....|.:...
Zfish    35 KDITTAFVLRTKVHGLKHAFSPHKSKTQRLFWLLALLVCLGLLFTWS--WNRILYLLSYPAVTKI 97

  Fly   126 DETLVPVHKIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQNGNISDL--DDEDLARMAVAMH 188
              .:|..:.:.||.||.|.:.::        .||....::...:|...|:  .:..|.|.:|:|
Zfish    98 --YMVWSNNMTFPAITFCNQNRL--------RVSSLTRDDLYYSGYWMDILHLNHTLNRQSVSM- 151

  Fly   189 ICDSEVVQRFTPLL--SQLNPP---NVDVTQTLIDLSISKNETGPFCKWNGRFYFCD-KIFDFVA 247
            :..|...:|...||  |..:||   :::.|:.:..|.....:....|::.|.  .|. |.|..:.
Zfish   152 LKHSRHRERLLHLLDFSHYSPPPDQSLNTTEMIDRLGHQLQDMLLECRFRGE--NCTYKNFTPIY 214

  Fly   248 TDEGICYQF------------------NGLR-PKDIYRDEKFISYVDPDVVDFNKYFDV-----D 288
            |..|.||.|                  |||. ..||.:||....:.|.|...:.....|     |
Zfish   215 TRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIMLDIQQDEYLPVWGDTDETSYEAGIKVQIHSQD 279

  Fly   289 LPPWNNITGNWSLDTGFVDQ-GQNAYPQRTVFSSVKNGFFAFLQGLQHNFDYDCRSFKQGYKVFL 352
            .||             |:|| |....|                                |::.|:
Zfish   280 EPP-------------FIDQLGFGVAP--------------------------------GFQTFV 299

  Fly   353 NSPESVPLTTGNYILVPHGDEVLVSVLPAYVVSTDNLHEITPEKRQCLFDDERSLRFFRSYSQSN 417
            :..:.:.|    |:..|.||                       .|....|.|    :|.:||.:.
Zfish   300 SCQQQLLL----YLPPPWGD-----------------------CRSAPMDSE----YFSTYSITA 333

  Fly   418 CQTECLANYTVSKCGCAKFWMPKPLGT-PVC---GLKDINCYTSAQDELYTLMQNQTMAKSIDES 478
            |:.:|...|.:..|.|....||   || .||   ..||  |...|.|.|            :::.
Zfish   334 CRIDCETRYLLENCNCRMVHMP---GTSTVCTPEQYKD--CADPALDFL------------VEKD 381

  Fly   479 VDITCNCMPACTSLEYNFEISRAKYDVAKTIRAFREEYEHTDAIGSR----LSVYFKEHQFTAIK 539
            .|. |.|...|....|..|:|..|.....:.:...:::..|:...:.    |.::|:...:..|:
Zfish   382 NDY-CVCDTPCNMTRYGKELSMVKIPSKASAKYLAKKFNKTEQYITDNILVLDIFFEALNYEKIE 445

  Fly   540 RTILFGVSTLISNCGGICGLFMGISCLSFLELI-YFFCM---RICGS-CRDRRKHKIQQQNSVDL 599
            :...:.|:.|:.:.||..|||:|.|.|:.||:. |.:.:   :|.|| .|.||.|:....| :|.
Zfish   446 QKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVLKDKILGSVLRKRRPHRSASDN-LDF 509

  Fly   600 PE 601
            .|
Zfish   510 SE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:279230	119/548 (22%)
asic1c	XP_021325802.1	ASC	34..531	CDD:322155	131/587 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26495
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.070